Figure 1
Take five—BACE and the 
-secretase quartet conduct Alzheimer's amyloid 
-peptide generation
Christian Haass
- The EMBO Journal (2004) 23, 483 - 488
- doi:10.1038/sj.emboj.7600061
Published online: 29 January 2004
Back to article
Generation of A
from APP via proteolytic processing by - and 
-secretase (for details, see text). A aggregates and finally precipitates in amyloid plaques. This event initiates the amyloid cascade resulting in additional intracellular aggregations of the tau protein, which then form tangles (the black structures surrounding the amyloid plaque).
