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| Subject Categories: Molecular Biology of Disease | Neuroscience |
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| The EMBO Journal
(2004) 23, 483–488, doi:10.1038/sj.emboj.7600061 Published online 29 January 2004 |
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Take five—BACE and the  -secretase quartet conduct Alzheimer's amyloid  -peptide generation |
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| Christian Haass |
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Department of Biochemistry, Adolf-Butenandt-Institute, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, München, Germany To whom correspondence should be addressed Christian Haass, Department of Biochemistry, Adolf-Butenandt-Institute, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstr. 44 80336, München, Germany. Tel.: +89 5996 471; Fax: +89 5996 415; E-mail: chaass@pbm.med.uni-muenchen.de Received 23 October 2003; Accepted 9 December 2003; Published online 29 January 2004. |
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| Abstract |
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| In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of the most defiant time signatures in all music. Of similar revolutionary importance for biomedical and basic biochemical research is the identification of the minimal set of genes required to obtain a deadly time bomb ticking in all of us: Alzheimer's disease. It now appears that one needs to Take Five genes to produce a deadly peptide by a proteolytic mechanism, which paradoxically is otherwise of pivotal importance for development and cell fate decisions. |
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| Keywords: Alzheimer's disease, amyloid -peptide, processing, secretases |
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Top of page MORE ARTICLES LIKE THISThese links to content published by NPG are automatically generated NEWS AND VIEWSNeurobiology Ballads of a protein quartet Nature News and Views (27 Mar 2003) Alzheimer's disease Closing in on γ-secretase Nature News and Views (08 Jun 2000) Alzheimer's disease A firm base for drug development Nature News and Views (02 Dec 1999) |
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