Table of Contents

Volume 23, Number 17
01 September 2004

pp 3441-3582

Crystal structure of the nuclear effector of Notch signaling. Both the CSL transcription factor and its recognition sites on DNA are highly conserved from flies and worms, to mice and humans. Notch-controlled genes are switched on when the cytoplasmic domain is released from activated Notch and binds to a novel CSL domain in this complex. For details, see the article by Rhett Kovall and Wayne Hendrickson, on pages 3441-3451 of this issue.

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  • Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA FREE

    Rhett A Kovall and Wayne A Hendrickson

    The EMBO Journal (2004), 23, - 3441 - 3451, doi:10.1038/sj.emboj.7600349

    • Abstract - Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
    • Full text
    • PDF (541 KB) - Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
    • Supplementary information

    Published online: 05 August 2004

    Subject Categories:

    • Structural Biology | Chromatin and Transcription

  • Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase FREE

    Luis G Brieba, Brandt F Eichman, Robert J Kokoska, Sylvie Doublié, Tom A Kunkel and Tom Ellenberger

    The EMBO Journal (2004), 23, - 3452 - 3461, doi:10.1038/sj.emboj.7600354

    • Abstract - Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase
    • Full text
    • PDF (374 KB) - Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase

    Published online: 05 August 2004

    Subject Categories:

    • Structural Biology | Genome Stability and Dynamics

  • Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase FREE

    Aaron A Thompson and Olve B Peersen

    The EMBO Journal (2004), 23, - 3462 - 3471, doi:10.1038/sj.emboj.7600357

    • Abstract - Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase
    • Full text
    • PDF (496 KB) - Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase

    Published online: 12 August 2004

    Subject Categories:

    • Structural Biology | Microbiology and Pathogens

  • Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae FREE

    Antoni Barrientos, Andrea Zambrano and Alexander Tzagoloff

    The EMBO Journal (2004), 23, - 3472 - 3482, doi:10.1038/sj.emboj.7600358

    • Abstract - Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in : Saccharomyces cerevisiae
    • Full text
    • PDF (291 KB) - Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in : Saccharomyces cerevisiae

    Published online: 12 August 2004

    Subject Categories:

    • Membranes and Transport | Proteins

  • The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature FREE

    Yumi Yoshida, Masahiro Kinuta, Tadashi Abe, Shuang Liang, Kenta Araki, Ottavio Cremona, Gilbert Di Paolo, Yoshinori Moriyama, Tatsuji Yasuda, Pietro De Camilli and Kohji Takei

    The EMBO Journal (2004), 23, - 3483 - 3491, doi:10.1038/sj.emboj.7600355

    • Abstract - The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature
    • Full text
    • PDF (398 KB) - The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature

    Published online: 19 August 2004

    Subject Categories:

    • Membranes and Transport | Neuroscience

  • Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/-Pix FREE

    Qiyu Feng, Daniel Baird and Richard A Cerione

    The EMBO Journal (2004), 23, - 3492 - 3504, doi:10.1038/sj.emboj.7600331

    • Abstract - Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/[alpha]-Pix
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    Published online: 12 August 2004

    Subject Category:

    • Signal Transduction

  • Defective dendritic cell migration and activation of adaptive immunity in PI3K-deficient mice FREE

    Annalisa Del Prete, William Vermi, Erica Dander, Karel Otero, Laura Barberis, Walter Luini, Sergio Bernasconi, Marina Sironi, Amerigo Santoro, Cecilia Garlanda, Fabio Facchetti, Matthias P Wymann, Annunciata Vecchi, Emilio Hirsch, Alberto Mantovani and Silvano Sozzani

    The EMBO Journal (2004), 23, - 3505 - 3515, doi:10.1038/sj.emboj.7600361

    • Abstract - Defective dendritic cell migration and activation of adaptive immunity in PI3K[gamma]-deficient mice
    • Full text
    • PDF (534 KB) - Defective dendritic cell migration and activation of adaptive immunity in PI3K[gamma]-deficient mice

    Published online: 19 August 2004

    Subject Categories:

    • Signal Transduction | Immunology

  • A CAF-1 dependent pool of HP1 during heterochromatin duplication FREE

    Jean-Pierre Quivy, Danièle Roche, Doris Kirschner, Hideaki Tagami, Yoshihiro Nakatani and Geneviève Almouzni

    The EMBO Journal (2004), 23, - 3516 - 3526, doi:10.1038/sj.emboj.7600362

    • Abstract - A CAF-1 dependent pool of HP1 during heterochromatin duplication
    • Full text
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    • Supplementary information

    Published online: 12 August 2004

    Subject Categories:

    • Chromatin and Transcription | Genome Stability and Dynamics

  • BMP-2 decreases Mash1 stability by increasing Id1 expression FREE

    Francesc Viñals, Julia Reiriz, Santiago Ambrosio, Ramon Bartrons, Jose Luis Rosa and Francesc Ventura

    The EMBO Journal (2004), 23, - 3527 - 3537, doi:10.1038/sj.emboj.7600360

    • Abstract - BMP-2 decreases Mash1 stability by increasing Id1 expression
    • Full text
    • PDF (291 KB) - BMP-2 decreases Mash1 stability by increasing Id1 expression

    Published online: 19 August 2004

    Subject Categories:

    • Signal Transduction | Differentiation and Death

  • Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila FREE

    Marek Jindra, Ivana Gaziova, Mirka Uhlirova, Masataka Okabe, Yasushi Hiromi and Susumu Hirose

    The EMBO Journal (2004), 23, - 3538 - 3547, doi:10.1038/sj.emboj.7600356

    • Abstract - Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in : Drosophila
    • Full text
    • PDF (386 KB) - Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in : Drosophila

    Published online: 12 August 2004

    Subject Categories:

    • Proteins | Development

  • Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination FREE

    Magda Budzowska, Iris Jaspers, Jeroen Essers, Harm de Waard, Ellen van Drunen, Katsuhiro Hanada, Berna Beverloo, Rudolf W Hendriks, Annelies de Klein, Roland Kanaar, Jan H Hoeijmakers and Alex Maas

    The EMBO Journal (2004), 23, - 3548 - 3558, doi:10.1038/sj.emboj.7600353

    • Abstract - Mutation of the mouse : Rad17: gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination
    • Full text
    • PDF (472 KB) - Mutation of the mouse : Rad17: gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

    Published online: 05 August 2004

    Subject Categories:

    • Cell Cycle | Genome Stability and Dynamics

  • Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure FREE

    Motoaki Sano, Sam C Wang, Manabu Shirai, Fernando Scaglia, Min Xie, Satoshi Sakai, Toru Tanaka, Prathit A Kulkarni, Philip M Barger, Keith A Youker, George E Taffet, Yasuo Hamamori, Lloyd H Michael, William J Craigen and Michael D Schneider

    The EMBO Journal (2004), 23, - 3559 - 3569, doi:10.1038/sj.emboj.7600351

    • Abstract - Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure
    • Full text
    • PDF (606 KB) - Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure
    • Supplementary information

    Published online: 05 August 2004

    Subject Categories:

    • Differentiation and Death | Molecular Biology of Disease

  • Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1 FREE

    Takeshi Matsuzawa, Asaomi Kuwae, Sei Yoshida, Chihiro Sasakawa and Akio Abe

    The EMBO Journal (2004), 23, - 3570 - 3582, doi:10.1038/sj.emboj.7600359

    • Abstract - Enteropathogenic : Escherichia coli: activates the RhoA signaling pathway via the stimulation of GEF-H1
    • Full text
    • PDF (856 KB) - Enteropathogenic : Escherichia coli: activates the RhoA signaling pathway via the stimulation of GEF-H1
    • Supplementary information

    Published online: 19 August 2004

    Subject Categories:

    • Microbiology and Pathogens | Molecular Biology of Disease

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