Table of Contents
Volume 22, Number 20
15 October 2003
pp 5323-5653
Cover. Flagellum mutants in trypanosomes. Flagellum assembly has been perturbed by inducible RNAi silencing of the intraflagellar transport machinery. The image shows a mixture of trypanosome cells with normal flagella, with flagella that are too short, or without flagella. The flagellum is stained in green, its basal body is stained in red (spots), and DNA is stained in blue. In trypanosomes, the flagellum is attached along the length of the cell body where a specific structure called the Flagellum Attachment Zone (FAZ) filament can be seen here as a thin red line. The length of the flagellum governs the cell body size (note the difference in cell body size between non-flagellated-no green signal-and normal flagellated cells). By regulating the assembly of the FAZ, the flagellum is required for proper cell morphogenesis and definition of the initiation of cytokinesis. See Kohl et al., 5336-5346].
Articles
Top of pageEZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer FREE
The EMBO Journal (2003), 22, - 5323 - 5335, doi:10.1093/emboj/cdg542
- Abstract - EZH2: is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
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- PDF (588 KB) - EZH2: is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
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Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes FREE
The EMBO Journal (2003), 22, - 5336 - 5346, doi:10.1093/emboj/cdg518
- Abstract - Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes
- Full text
- PDF (367 KB) - Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes
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Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling FREE
The EMBO Journal (2003), 22, - 5347 - 5357, doi:10.1093/emboj/cdg514
- Abstract - Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
- Full text
- PDF (532 KB) - Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
- Supplementary information
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Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import FREE
The EMBO Journal (2003), 22, - 5358 - 5369, doi:10.1093/emboj/cdg538
- Abstract - Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import
- Full text
- PDF (451 KB) - Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import
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Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM–TIM–preprotein supercomplex FREE
The EMBO Journal (2003), 22, - 5370 - 5381, doi:10.1093/emboj/cdg532
- Abstract - Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex
- Full text
- PDF (467 KB) - Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex
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Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd FREE
The EMBO Journal (2003), 22, - 5382 - 5389, doi:10.1093/emboj/cdg531
- Abstract - Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd
- Full text
- PDF (229 KB) - Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd
- Supplementary information
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Interaction of fascin and protein kinase C
: a novel intersection in cell adhesion and motility
FREE The EMBO Journal (2003), 22, - 5390 - 5402, doi:10.1093/emboj/cdg521
- Abstract - Interaction of fascin and protein kinase C[alpha]: a novel intersection in cell adhesion and motility
- Full text
- PDF (628 KB) - Interaction of fascin and protein kinase C[alpha]: a novel intersection in cell adhesion and motility
- Supplementary information
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Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels FREE
The EMBO Journal (2003), 22, - 5403 - 5411, doi:10.1093/emboj/cdg528
- Abstract - Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K: +: channels
- Full text
- PDF (395 KB) - Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K: +: channels
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Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels FREE
The EMBO Journal (2003), 22, - 5412 - 5421, doi:10.1093/emboj/cdg526
- Abstract - Phosphatidylinositol-4,5-bisphosphate, PIP: 2: , controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K: +: channels
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- PDF (416 KB) - Phosphatidylinositol-4,5-bisphosphate, PIP: 2: , controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K: +: channels
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Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold FREE
The EMBO Journal (2003), 22, - 5422 - 5434, doi:10.1093/emboj/cdg519
- Abstract - Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
- Full text
- PDF (728 KB) - Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
- Supplementary information
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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein FREE
The EMBO Journal (2003), 22, - 5435 - 5445, doi:10.1093/emboj/cdg537
- Abstract - Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein
- Full text
- PDF (459 KB) - Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein
- Supplementary information
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CHIP activates HSF1 and confers protection against apoptosis and cellular stress FREE
The EMBO Journal (2003), 22, - 5446 - 5458, doi:10.1093/emboj/cdg529
- Abstract - CHIP activates HSF1 and confers protection against apoptosis and cellular stress
- Full text
- PDF (542 KB) - CHIP activates HSF1 and confers protection against apoptosis and cellular stress
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Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry FREE
The EMBO Journal (2003), 22, - 5459 - 5470, doi:10.1093/emboj/cdg533
- Abstract - Bcl-x: L: /Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry
- Full text
- PDF (624 KB) - Bcl-x: L: /Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry
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Abl tyrosine kinases are required for infection by Shigella flexneri FREE
The EMBO Journal (2003), 22, - 5471 - 5479, doi:10.1093/emboj/cdg512
- Abstract - Abl tyrosine kinases are required for infection by : Shigella flexneri
- Full text
- PDF (241 KB) - Abl tyrosine kinases are required for infection by : Shigella flexneri
- Supplementary information
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SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-
receptor
FREE The EMBO Journal (2003), 22, - 5480 - 5490, doi:10.1093/emboj/cdg524
- Abstract - SCF: HOS: ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-[alpha] receptor
- Full text
- PDF (425 KB) - SCF: HOS: ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-[alpha] receptor
- Supplementary information
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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation FREE
The EMBO Journal (2003), 22, - 5491 - 5500, doi:10.1093/emboj/cdg540
- Abstract - Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
- Full text
- PDF (302 KB) - Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
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Redox regulation of PI 3-kinase signalling via inactivation of PTEN FREE
The EMBO Journal (2003), 22, - 5501 - 5510, doi:10.1093/emboj/cdg513
- Abstract - Redox regulation of PI 3-kinase signalling via inactivation of PTEN
- Full text
- PDF (301 KB) - Redox regulation of PI 3-kinase signalling via inactivation of PTEN
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Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor FREE
The EMBO Journal (2003), 22, - 5511 - 5521, doi:10.1093/emboj/cdg522
- Abstract - Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor
- Full text
- PDF (530 KB) - Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor
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Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation FREE
The EMBO Journal (2003), 22, - 5522 - 5529, doi:10.1093/emboj/cdg536
- Abstract - Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation
- Full text
- PDF (231 KB) - Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation
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Genetic analysis of NF-
B/Rel transcription factors defines functional specificities
FREE The EMBO Journal (2003), 22, - 5530 - 5539, doi:10.1093/emboj/cdg534
- Abstract - Genetic analysis of NF-[kappa]B/Rel transcription factors defines functional specificities
- Full text
- PDF (345 KB) - Genetic analysis of NF-[kappa]B/Rel transcription factors defines functional specificities
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Formation of facultative heterochromatin in the absence of HP1 FREE
The EMBO Journal (2003), 22, - 5540 - 5550, doi:10.1093/emboj/cdg520
- Abstract - Formation of facultative heterochromatin in the absence of HP1
- Full text
- PDF (368 KB) - Formation of facultative heterochromatin in the absence of HP1
- Supplementary information
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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion FREE
The EMBO Journal (2003), 22, - 5551 - 5560, doi:10.1093/emboj/cdg516
- Abstract - Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
- Full text
- PDF (408 KB) - Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
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Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity FREE
The EMBO Journal (2003), 22, - 5561 - 5570, doi:10.1093/emboj/cdg530
- Abstract - Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity
- Full text
- PDF (267 KB) - Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity
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A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA FREE
The EMBO Journal (2003), 22, - 5571 - 5581, doi:10.1093/emboj/cdg539
- Abstract - A co-repressor assembly nucleated by Sex-lethal in the 3[prime]UTR mediates translational control of : Drosophila msl-2: mRNA
- Full text
- PDF (386 KB) - A co-repressor assembly nucleated by Sex-lethal in the 3[prime]UTR mediates translational control of : Drosophila msl-2: mRNA
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Upstream AUGs in embryonic proinsulin mRNA control its low translation level FREE
The EMBO Journal (2003), 22, - 5582 - 5592, doi:10.1093/emboj/cdg515
- Abstract - Upstream AUGs in embryonic proinsulin mRNA control its low translation level
- Full text
- PDF (458 KB) - Upstream AUGs in embryonic proinsulin mRNA control its low translation level
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The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis FREE
The EMBO Journal (2003), 22, - 5593 - 5601, doi:10.1093/emboj/cdg525
- Abstract - The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis
- Full text
- PDF (324 KB) - The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis
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A replication silencer element in a plus-strand RNA virus FREE
The EMBO Journal (2003), 22, - 5602 - 5611, doi:10.1093/emboj/cdg523
- Abstract - A replication silencer element in a plus-strand RNA virus
- Full text
- PDF (357 KB) - A replication silencer element in a plus-strand RNA virus
- Supplementary information
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Requirement of the MRN complex for ATM activation by DNA damage FREE
The EMBO Journal (2003), 22, - 5612 - 5621, doi:10.1093/emboj/cdg541
- Abstract - Requirement of the MRN complex for ATM activation by DNA damage
- Full text
- PDF (344 KB) - Requirement of the MRN complex for ATM activation by DNA damage
- Supplementary information
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Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response FREE
The EMBO Journal (2003), 22, - 5622 - 5632, doi:10.1093/emboj/cdg543
- Abstract - Dmp53 protects the : Drosophila: retina during a developmentally regulated DNA damage response
- Full text
- PDF (736 KB) - Dmp53 protects the : Drosophila: retina during a developmentally regulated DNA damage response
- Supplementary information
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Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles FREE
The EMBO Journal (2003), 22, - 5633 - 5642, doi:10.1093/emboj/cdg535
- Abstract - Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles
- Full text
- PDF (390 KB) - Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles
- Supplementary information
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Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast FREE
The EMBO Journal (2003), 22, - 5643 - 5653, doi:10.1093/emboj/cdg527
- Abstract - Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast
- Full text
- PDF (388 KB) - Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast
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