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The EMBO Journal (2003) 22, 4910–4921, doi:10.1093/emboj/cdg500 Figure 5 High-resolution structure of the E.coli RecQ helicase catalytic core Douglas A. Bernstein, Morgan C. Zittel and James L. Keck

Figure 5 Structural comparison of RecQC to representative helicases belonging to the SF1 and SF2 helicase superfamilies. (A) Structures of PcrA (Subramanya et al., 1996) and NS3 (Yao et al., 1997), SF1 and SF2 helicases, respectively, were superimposed on RecQC using the structurally related C atoms in their N-terminal most helicase subdomains (in red) and then translated to allow visual comparison. Red and blue colors mark the conserved RecA-like folds found in the helicase subdomains of each protein, while grey coloration indicates sequences outside of the RecA fold. An orthogonal view is shown of each protein below the top row. (B) Topology diagrams of PcrA, RecQC and NS3. Colors are shown as in (A), with RecQC's Zn2+ in magenta. Helices and -strands in RecQC are labeled as in Figure 1B. Diagrams of PcrA and NS3 were adapted from Caruthers and McKay (2002).

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