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The EMBO Journal (2002) 21, 6338–6347, doi: 10.1093/emboj/cdf649 Figure 7 Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium Marjorie Jenny, Céline Uhl, Colette Roche, Isabelle Duluc, Valérie Guillermin, Francois Guillemot, Jan Jensen, Michèle Kedinger and Gérard Gradwohl

Figure 7 Gastric endocrine specification is both ngn3 dependent and independent. Cells expressing the endocrine marker chromogranin A (CA) (A), and the hormones gastrin (B), somatostatin (C), serotonin (D) and ghrelin (E) are detected by immunohistochemistry in the wild-type gastric mucosa at birth. In ngn3 mutants, gastrin-secreting G cells (B') and somatostatin-secreting D cells (C') are lost. However, endocrine cells expressing chromogranin A (A'), serotonin (D') and ghrelin (E') are still observed. Histidine decarboxylase (HDC), a specific marker of ECL cells, is expressed in both grafted control (F) and ngn3-deficient (F') stomachs at postnatal stages. The arrowhead in (B') points to a rare G cell detected in ngn3-/- stomach.

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