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| Subject Categories: RNA | Neuroscience |
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| The EMBO Journal
(2002) 21, 6025–6035, doi: 10.1093/emboj/cdf607 |
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| RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans |
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| Leath A. Tonkin1, 4, Lisa Saccomanno1, 4, Daniel P. Morse1, 2, Thomas Brodigan3, Michael Krause3 and Brenda L. Bass1 |
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1 Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132, USA 2 Present address: Chemistry Department, US Naval Academy, M572 Holloway Road, Annapolis, MD 21402, USA 3 Laboratory of Molecular Biology, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA 4 L.A.Tonkin and L.Saccomanno contributed equally to this work To whom correspondence should be addressed Brenda L. Bass, bbass@howard.genetics.utah.edu Received 6 August 2002; Revised 19 September 2002; Accepted 24 September 2002. |
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| Abstract |
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| Here we take advantage of the well-characterized and simple nervous system of Caenorhabditis elegans to further our understanding of the functions of RNA editing. We describe the two C.elegans ADAR genes, adr-1 and adr-2, and characterize strains containing homozygous deletions in each, or both, of these genes. We find that adr-1 is expressed in most, if not all, cells of the C.elegans nervous system and also in the developing vulva. Using chemotaxis assays, we show that both ADARs are important for normal behavior. Biochemical, molecular and phenotypic analyses indicate that ADR-1 and ADR-2 have distinct roles in C.elegans, but sometimes act together. |
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| Keywords: chemotaxis, double-stranded RNA, inosine, neuronal, vulva |
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