Table of Contents
Volume 21, Number 21
01 November 2002
pp 5587-5953
Cover. Sectioned schematic view of an icosahedral pyruvate dehydrogenase complex based on electron cryo-microscopic analysis of an E1E2 sub-complex from B.stearothermophilus. Three of the 60 E2 molecules (colored red, green and yellow) are highlighted. The movement of the swinging E2 lipoyl domain in the annular region between the inner core (cyan) of E2 molecules and the outer shell of E1 molecules (purple) is proposed to be a critical feature underlying active site coupling in the complex. Jacqueline Milne and Sriram Subramaniam work at the National Cancer Institute, NIH in Bethesda, MD, USA (http://hrem.nci.nih.gov). The artist is Donald Bliss at the Medical Arts and Photography Branch at NIH. For further details, see Milne et al., pp. 5587--5598.
Articles
Top of pageMolecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: a multifunctional catalytic machine FREE
The EMBO Journal (2002), 21, - 5587 - 5598, doi:10.1093/emboj/cdf574
- Abstract - Molecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: a multifunctional catalytic machine
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- PDF (719 KB) - Molecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: a multifunctional catalytic machine
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Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme FREE
The EMBO Journal (2002), 21, - 5599 - 5610, doi:10.1093/emboj/cdf566
- Abstract - Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme
- Full text
- PDF (582 KB) - Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme
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Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling FREE
The EMBO Journal (2002), 21, - 5611 - 5622, doi:10.1093/emboj/cdf588
- Abstract - Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling
- Full text
- PDF (378 KB) - Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling
- Supplementary information
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GW domains of the Listeria monocytogenes invasion protein InlB are SH3-like and mediate binding to host ligands FREE
The EMBO Journal (2002), 21, - 5623 - 5634, doi:10.1093/emboj/cdf558
- Abstract - GW domains of the : Listeria monocytogenes: invasion protein InlB are SH3-like and mediate binding to host ligands
- Full text
- PDF (621 KB) - GW domains of the : Listeria monocytogenes: invasion protein InlB are SH3-like and mediate binding to host ligands
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p53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis FREE
The EMBO Journal (2002), 21, - 5635 - 5644, doi:10.1093/emboj/cdf591
- Abstract - p53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis
- Full text
- PDF (328 KB) - p53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis
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Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4 FREE
The EMBO Journal (2002), 21, - 5645 - 5652, doi:10.1093/emboj/cdf579
- Abstract - Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4
- Full text
- PDF (255 KB) - Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4
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Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate FREE
The EMBO Journal (2002), 21, - 5653 - 5661, doi:10.1093/emboj/cdf583
- Abstract - Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate
- Full text
- PDF (287 KB) - Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate
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A molecular mechanism for aberrantCFTR-dependent HCO3- transport in cystic fibrosis FREE
The EMBO Journal (2002), 21, - 5662 - 5672, doi:10.1093/emboj/cdf580
- Abstract - A molecular mechanism for aberrantCFTR-dependent HCO: 3: -: transport in cystic fibrosis
- Full text
- PDF (453 KB) - A molecular mechanism for aberrantCFTR-dependent HCO: 3: -: transport in cystic fibrosis
- Supplementary information
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Topology of polytopic membrane protein subdomains is dictated by membrane phospholipid composition FREE
The EMBO Journal (2002), 21, - 5673 - 5681, doi:10.1093/emboj/cdf571
- Abstract - Topology of polytopic membrane protein subdomains is dictated by membrane phospholipid composition
- Full text
- PDF (233 KB) - Topology of polytopic membrane protein subdomains is dictated by membrane phospholipid composition
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The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation FREE
The EMBO Journal (2002), 21, - 5682 - 5690, doi:10.1093/emboj/cdf573
- Abstract - The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation
- Full text
- PDF (255 KB) - The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation
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The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing FREE
The EMBO Journal (2002), 21, - 5691 - 5700, doi:10.1093/emboj/cdf568
- Abstract - The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing
- Full text
- PDF (299 KB) - The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing
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Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutinin FREE
The EMBO Journal (2002), 21, - 5701 - 5710, doi:10.1093/emboj/cdf559
- Abstract - Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutinin
- Full text
- PDF (289 KB) - Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutinin
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An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK–APRIL fusion protein FREE
The EMBO Journal (2002), 21, - 5711 - 5720, doi:10.1093/emboj/cdf565
- Abstract - An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein
- Full text
- PDF (366 KB) - An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein
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Structure of the sporulation-specific transcription factor Ndt80 bound to DNA FREE
The EMBO Journal (2002), 21, - 5721 - 5732, doi:10.1093/emboj/cdf572
- Abstract - Structure of the sporulation-specific transcription factor Ndt80 bound to DNA
- Full text
- PDF (611 KB) - Structure of the sporulation-specific transcription factor Ndt80 bound to DNA
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Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA FREE
The EMBO Journal (2002), 21, - 5733 - 5744, doi:10.1093/emboj/cdf575
- Abstract - Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA
- Full text
- PDF (476 KB) - Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA
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plo1+ regulates gene transcription at the M–G1 interval during the fission yeast mitotic cell cycle FREE
The EMBO Journal (2002), 21, - 5745 - 5755, doi:10.1093/emboj/cdf564
- Abstract - plo1: +: regulates gene transcription at the M-G: 1: interval during the fission yeast mitotic cell cycle
- Full text
- PDF (377 KB) - plo1: +: regulates gene transcription at the M-G: 1: interval during the fission yeast mitotic cell cycle
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Stress-induced decrease in TRAF2 stability is mediated by Siah2 FREE
The EMBO Journal (2002), 21, - 5756 - 5765, doi:10.1093/emboj/cdf576
- Abstract - Stress-induced decrease in TRAF2 stability is mediated by Siah2
- Full text
- PDF (382 KB) - Stress-induced decrease in TRAF2 stability is mediated by Siah2
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The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells FREE
The EMBO Journal (2002), 21, - 5766 - 5774, doi:10.1093/emboj/cdf562
- Abstract - The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells
- Full text
- PDF (230 KB) - The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells
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Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function FREE
The EMBO Journal (2002), 21, - 5775 - 5786, doi:10.1093/emboj/cdf577
- Abstract - Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function
- Full text
- PDF (370 KB) - Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function
- Supplementary information
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Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1 FREE
The EMBO Journal (2002), 21, - 5787 - 5796, doi:10.1093/emboj/cdf561
- Abstract - Loss of : spr-5: bypasses the requirement for the : C.elegans: presenilin : sel-12: by derepressing : hop-1
- Full text
- PDF (379 KB) - Loss of : spr-5: bypasses the requirement for the : C.elegans: presenilin : sel-12: by derepressing : hop-1
- Supplementary information
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Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1
FREE The EMBO Journal (2002), 21, - 5797 - 5806, doi:10.1093/emboj/cdf560
- Abstract - Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1[alpha]
- Full text
- PDF (324 KB) - Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1[alpha]
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The imprinting mechanism of the Prader–Willi/Angelman regional control center FREE
The EMBO Journal (2002), 21, - 5807 - 5814, doi:10.1093/emboj/cdf570
- Abstract - The imprinting mechanism of the Prader-Willi/Angelman regional control center
- Full text
- PDF (311 KB) - The imprinting mechanism of the Prader-Willi/Angelman regional control center
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The phage N4 virion RNA polymerase catalytic domain is related to single-subunit RNA polymerases FREE
The EMBO Journal (2002), 21, - 5815 - 5823, doi:10.1093/emboj/cdf584
- Abstract - The phage N4 virion RNA polymerase catalytic domain is related to single-subunit RNA polymerases
- Full text
- PDF (436 KB) - The phage N4 virion RNA polymerase catalytic domain is related to single-subunit RNA polymerases
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An active role for endogenous
-1,3-glucanase genes in transgene-mediated co-suppression in tobacco
FREE The EMBO Journal (2002), 21, - 5824 - 5832, doi:10.1093/emboj/cdf586
- Abstract - An active role for endogenous [beta]-1,3-glucanase genes in transgene-mediated co-suppression in tobacco
- Full text
- PDF (265 KB) - An active role for endogenous [beta]-1,3-glucanase genes in transgene-mediated co-suppression in tobacco
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Importin
can migrate into the nucleus in an importin - and Ran-independent manner
FREE The EMBO Journal (2002), 21, - 5833 - 5842, doi:10.1093/emboj/cdf569
- Abstract - Importin [alpha] can migrate into the nucleus in an importin [beta]- and Ran-independent manner
- Full text
- PDF (329 KB) - Importin [alpha] can migrate into the nucleus in an importin [beta]- and Ran-independent manner
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The mRNA export machinery requires the novel Sac3p–Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores FREE
Tamás Fischer, Katja Strä
er,
Attila Rácz,
Susana Rodriguez-Navarro,
Marisa Oppizzi,
Petra Ihrig,
Johannes Lechner and Ed HurtThe EMBO Journal (2002), 21, - 5843 - 5852, doi:10.1093/emboj/cdf590
- Abstract - The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores
- Full text
- PDF (425 KB) - The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores
- Supplementary information
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Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs FREE
The EMBO Journal (2002), 21, - 5853 - 5863, doi:10.1093/emboj/cdf585
- Abstract - Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs
- Full text
- PDF (359 KB) - Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs
- Supplementary information
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Ribonuclease activity and RNA binding of recombinant human Dicer FREE
The EMBO Journal (2002), 21, - 5864 - 5874, doi:10.1093/emboj/cdf578
- Abstract - Ribonuclease activity and RNA binding of recombinant human Dicer
- Full text
- PDF (346 KB) - Ribonuclease activity and RNA binding of recombinant human Dicer
- Supplementary information
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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP FREE
The EMBO Journal (2002), 21, - 5875 - 5885, doi:10.1093/emboj/cdf582
- Abstract - Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
- Full text
- PDF (316 KB) - Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
- Supplementary information
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Direct eIF2–eIF3 contact in the multifactor complex is important for translation initiation in vivo FREE
Leo
Valáek,
Klaus H. Nielsen and Alan G. HinnebuschThe EMBO Journal (2002), 21, - 5886 - 5898, doi:10.1093/emboj/cdf563
- Abstract - Direct eIF2–eIF3 contact in the multifactor complex is important for translation initiation : in vivo
- Full text
- PDF (508 KB) - Direct eIF2–eIF3 contact in the multifactor complex is important for translation initiation : in vivo
- Supplementary information
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Human L1 element target-primed reverse transcription in vitro FREE
The EMBO Journal (2002), 21, - 5899 - 5910, doi:10.1093/emboj/cdf592
- Abstract - Human L1 element target-primed reverse transcription : in vitro
- Full text
- PDF (434 KB) - Human L1 element target-primed reverse transcription : in vitro
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Regulation of G2/M events by Cdc25A through phosphorylation-dependent modulation of its stability FREE
The EMBO Journal (2002), 21, - 5911 - 5920, doi:10.1093/emboj/cdf567
- Abstract - Regulation of G: 2: /M events by Cdc25A through phosphorylation-dependent modulation of its stability
- Full text
- PDF (304 KB) - Regulation of G: 2: /M events by Cdc25A through phosphorylation-dependent modulation of its stability
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Rpb4 and Rpb9 mediate subpathways of transcription-coupled DNA repair in Saccharomyces cerevisiae FREE
The EMBO Journal (2002), 21, - 5921 - 5929, doi:10.1093/emboj/cdf589
- Abstract - Rpb4 and Rpb9 mediate subpathways of transcription-coupled DNA repair in : Saccharomyces cerevisiae
- Full text
- PDF (372 KB) - Rpb4 and Rpb9 mediate subpathways of transcription-coupled DNA repair in : Saccharomyces cerevisiae
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The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair FREE
The EMBO Journal (2002), 21, - 5930 - 5942, doi:10.1093/emboj/cdf587
- Abstract - The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair
- Full text
- PDF (457 KB) - The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair
- Supplementary information
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DNA base excision repair of uracil residues in reconstituted nucleosome core particles FREE
The EMBO Journal (2002), 21, - 5943 - 5952, doi:10.1093/emboj/cdf581
- Abstract - DNA base excision repair of uracil residues in reconstituted nucleosome core particles
- Full text
- PDF (300 KB) - DNA base excision repair of uracil residues in reconstituted nucleosome core particles
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Corrigendum
Top of pageCrystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor FREE
The EMBO Journal (2002), 21, - 5953, doi:10.1093/emboj/cdf615
Retraction
Top of pageIgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution FREE
The EMBO Journal (2002), 21, - 5953, doi:10.1093/emboj/cdf617
