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The EMBO Journal (2002) 21, 5587–5598, doi: 10.1093/emboj/cdf574 Figure 5 Molecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: a multifunctional catalytic machine Jacqueline L.S. Milne, Dan Shi, Peter B. Rosenthal, Joshua S. Sunshine, Gonzalo J. Domingo, Xiongwu Wu, Bernard R. Brooks, Richard N. Perham, Richard Henderson and Sriram Subramaniam

Figure 5 (A and B) Views from the 3- and 5-fold axes of the manual fit of atomic coordinates of the backbone C atoms of a single E1 22 tetramer into the density of the 3D map of the E1E2 complex generated by electron microscopy. The E2 peripheral subunit-binding domains are shown in red. (C) Sectioned view of the density for the E1E2 complex with 60 manually-docked copies each of the atomic coordinates of the E1 22 tetramer, the E2 catalytic domain and the E2 peripheral subunit-binding domain. Sixty radial spokes have been included to illustrate the probable location of the linker domain connecting the peripheral subunit-binding and catalytic domains of the E2 chain.

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