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| The EMBO Journal
(2001) 20, 2140–2151, doi:10.1093/emboj/20.9.2140 |
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| The tripartite motif family identifies cell compartments |
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| Alexandre Reymond1, 2, 8, Germana Meroni1, 3, 8, Anna Fantozzi4, 5, Giuseppe Merla1, 3, Stefano Cairo1, 3, Lucilla Luzi4, 5, Daniela Riganelli4, Elena Zanaria1, Silvia Messali1, Silvia Cainarca1, Alessandro Guffanti1, Saverio Minucci5, Pier Giuseppe Pelicci4, 5, 6 and Andrea Ballabio1, 3, 6, 7 |
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1 Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy 2 Present address: Division of Medical Genetics, Geneva University Medical School, 1 rue Michel Servet, 1211 Geneva 4, Switzerland 3 Present address: TIGEM, Via Pietro Castellino 111, 80131 Naples, Italy 4 Internal Medicine and Oncological Sciences Institute, Perugia University, 06100 Perugia, Italy 5 Department of Experimental Oncology, European Institute of Oncology (IEO), 20141 Milan, Italy 6 TIGEM, Via Pietro Castellino 111, 80131 Naples or Department of Experimental Oncology, European Institute of Oncology (IEO), Via Ripamonti 435, 20141 Milan, Italy 7 Università Vita e Salute, San Raffaele Biomedical Science Park, Milan, Italy 8 A.Reymond and G.Meroni contributed equally to this work To whom correspondence should be addressed Pier Giuseppe Pelicci, pgpelicci@ieo.it Andrea Ballabio, ballabio@tigem.it Received 26 October 2000; Revised 8 March 2001; Accepted 14 March 2001. |
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| Abstract |
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| A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments. |
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| Keywords: cell compartmentalization, functional genomics, nuclear bodies, RBCC, tripartite motif |
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