Table of Contents

cover image

Volume 20, Number 8
17 April 2001

pp 1819-2108

Cover. A confocal micrograph of cultured primary rat neonatal ventriculocytes following induction of hypertrophy after exposure to phenylephrine. Dodge et al. have demonstrated the formation of a signaling complex in heart tissues that includes mAKAP (blue), cAMP-dependent protein kinase A (PKA) and cAMP-specific phosphodiesterase (PDE4D3; green), to maintain a negative feedback loop. Actin (red) displays a characteristic pattern associated with hypertrophy in these cells. Imaging was carried out in a BioRad MRC1024UV/VIS confocal microscope. John D.Scott is a Howard Hughes Medical Institute Associate Investigator and a Senior Scientist at the Vollum Institute in Portland, Oregon. For further details see Dodge et al., pages 1921--1930.

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