Table of Contents : The EMBO Journal

Volume 20, Number 22
15 November 2001

pp 6169-6558

Cover. The cover image presents a view into a breeding colony of Royal penguins on Macquarie Island. The photograph was taken by Professor Ben de Kruijff during a birdwatching expedition to the subantarctic islands of New Zealand and Australia in December 1998. Professor de Kruijff is presently head of the Department of Biochemistry of Membranes at the University of Utrecht, The Netherlands. His general research interest is structure--function relationships in biological membranes with special emphasis on lipid--protein interactions, lipid transport and polymorphism, and the mode of action of membrane-active drugs and toxins.

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Medal Review
Top of page
- The beginning of the end FREE
  Daniel St Johnston
  The EMBO Journal (2001), 20, - 6169 - 6179, doi:10.1093/emboj/20.22.6169
  - Full text
  - PDF (272 KB) - The beginning of the end
Articles
Top of page
- Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IB protein family FREE
  Fabrice Michel, Montserrat Soler-Lopez, Carlo Petosa, Patrick Cramer, Ulrich Siebenlist and Christoph W. Müller
  The EMBO Journal (2001), 20, - 6180 - 6190, doi:10.1093/emboj/20.22.6180
  - Abstract - Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the I[kappa]B protein family
  - Full text
  - PDF (642 KB) - Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the I[kappa]B protein family
- Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture FREE
  Caroline Peneff, Paul Ferrari, Véronique Charrier, Yvette Taburet, Célia Monnier, Véronique Zamboni, Jacques Winter, Marzia Harnois, Florence Fassy and Yves Bourne
  The EMBO Journal (2001), 20, - 6191 - 6202, doi:10.1093/emboj/20.22.6191
  - Abstract - Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture
  - Full text
  - PDF (616 KB) - Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture
- Molecular mechanisms of -catenin recognition by adenomatous polyposis coli revealed by the structure of an APC–-catenin complex FREE
  Katharine Eklof Spink, Sofiya G. Fridman and William I. Weis
  The EMBO Journal (2001), 20, - 6203 - 6212, doi:10.1093/emboj/20.22.6203
  - Abstract - Molecular mechanisms of [beta]-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-[beta]-catenin complex
  - Full text
  - PDF (361 KB) - Molecular mechanisms of [beta]-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-[beta]-catenin complex
- Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules FREE
  Y.-H. Song, A. Marx, J. Müller, G. Woehlke, M. Schliwa, A. Krebs, A. Hoenger and E. Mandelkow
  The EMBO Journal (2001), 20, - 6213 - 6225, doi:10.1093/emboj/20.22.6213
  - Abstract - Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules
  - Full text
  - PDF (741 KB) - Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules
  - Supplementary information
- Unusual properties of the fungal conventional kinesin neck domain from Neurospora crassa FREE
  Athina Kallipolitou, Dominga Deluca, Ulrike Majdic, Stefan Lakämper, Robert Cross, Edgar Meyhöfer, Luis Moroder, Manfred Schliwa and Günther Woehlke
  The EMBO Journal (2001), 20, - 6226 - 6235, doi:10.1093/emboj/20.22.6226
  - Abstract - Unusual properties of the fungal conventional kinesin neck domain from : Neurospora crassa
  - Full text
  - PDF (309 KB) - Unusual properties of the fungal conventional kinesin neck domain from : Neurospora crassa
  - Supplementary information
- Strains of [PSI⁺] are distinguished by their efficiencies of prion-mediated conformational conversion FREE
  Susan M. Uptain, George J. Sawicki, Byron Caughey and Susan Lindquist
  The EMBO Journal (2001), 20, - 6236 - 6245, doi:10.1093/emboj/20.22.6236
  - Abstract - Strains of [: PSI: +: ] are distinguished by their efficiencies of prion-mediated conformational conversion
  - Full text
  - PDF (366 KB) - Strains of [: PSI: +: ] are distinguished by their efficiencies of prion-mediated conformational conversion
- Apparent genetic redundancy facilitates ecological plasticity for nitrate transport FREE
  Shiela E. Unkles, Degen Zhou, M. Yaeesh Siddiqi, James R. Kinghorn and Anthony D. M. Glass
  The EMBO Journal (2001), 20, - 6246 - 6255, doi:10.1093/emboj/20.22.6246
  - Abstract - Apparent genetic redundancy facilitates ecological plasticity for nitrate transport
  - Full text
  - PDF (552 KB) - Apparent genetic redundancy facilitates ecological plasticity for nitrate transport
- Competing sorting signals guide endolyn along a novel route to lysosomes in MDCK cells FREE
  Gudrun Ihrke, Jennifer R. Bruns, J.Paul Luzio and Ora A. Weisz
  The EMBO Journal (2001), 20, - 6256 - 6264, doi:10.1093/emboj/20.22.6256
  - Abstract - Competing sorting signals guide endolyn along a novel route to lysosomes in MDCK cells
  - Full text
  - PDF (344 KB) - Competing sorting signals guide endolyn along a novel route to lysosomes in MDCK cells
  - Supplementary information
- Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs) FREE
  Markus Boehm, Rubén C. Aguilar and Juan S. Bonifacino
  The EMBO Journal (2001), 20, - 6265 - 6276, doi:10.1093/emboj/20.22.6265
  - Abstract - Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs)
  - Full text
  - PDF (619 KB) - Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs)
- Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca²⁺ stabilization FREE
  Ci-Di Chen, Mary E. Huff, Jeanne Matteson, Lesley Page, Rebecca Phillips, Jeffery W. Kelly and William E. Balch
  The EMBO Journal (2001), 20, - 6277 - 6287, doi:10.1093/emboj/20.22.6277
  - Abstract - Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca: 2+: stabilization
  - Full text
  - PDF (365 KB) - Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca: 2+: stabilization
  - Supplementary information
- Manipulation of oxidative protein folding and PDI redox state in mammalian cells FREE
  Alexandre Mezghrani, Anna Fassio, Adam Benham, Thomas Simmen, Ineke Braakman and Roberto Sitia
  The EMBO Journal (2001), 20, - 6288 - 6296, doi:10.1093/emboj/20.22.6288
  - Abstract - Manipulation of oxidative protein folding and PDI redox state in mammalian cells
  - Full text
  - PDF (311 KB) - Manipulation of oxidative protein folding and PDI redox state in mammalian cells
- Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53 FREE
  Frank W. King, Alicja Wawrzynow, Jörg Höhfeld and Maciej Zylicz
  The EMBO Journal (2001), 20, - 6297 - 6305, doi:10.1093/emboj/20.22.6297
  - Abstract - Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53
  - Full text
  - PDF (321 KB) - Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53
- Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate FREE
  Guy W.J. Makin, Bernard M. Corfe, Gareth J. Griffiths, Angela Thistlethwaite, John A. Hickman and Caroline Dive
  The EMBO Journal (2001), 20, - 6306 - 6315, doi:10.1093/emboj/20.22.6306
  - Abstract - Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate
  - Full text
  - PDF (386 KB) - Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate
- Asymmetrical, agonist-induced fluctuations in local extracellular [Ca²⁺] in intact polarized epithelia FREE
  Rosa Caroppo, Andrea Gerbino, Lucantonio Debellis, Olga Kifor, David I. Soybel, Edward M. Brown, Aldebaran M. Hofer and Silvana Curci
  The EMBO Journal (2001), 20, - 6316 - 6326, doi:10.1093/emboj/20.22.6316
  - Abstract - Asymmetrical, agonist-induced fluctuations in local extracellular [Ca: 2+: ] in intact polarized epithelia
  - Full text
  - PDF (577 KB) - Asymmetrical, agonist-induced fluctuations in local extracellular [Ca: 2+: ] in intact polarized epithelia
- ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation FREE
  Siew Hwa Ong, Stephen Dilworth, Ingrid Hauck-Schmalenberger, Tony Pawson and Friedemann Kiefer
  The EMBO Journal (2001), 20, - 6327 - 6336, doi:10.1093/emboj/20.22.6327
  - Abstract - ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation
  - Full text
  - PDF (307 KB) - ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation
- ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen FREE
  Philippa R. Nicholson, Sylvie Empereur, Hilary R. Glover and Stephen M. Dilworth
  The EMBO Journal (2001), 20, - 6337 - 6346, doi:10.1093/emboj/20.22.6337
  - Abstract - ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen
  - Full text
  - PDF (387 KB) - ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen
- Proteomic and functional evidence for a P2X₇ receptor signalling complex FREE
  Miran Kim, Lin-Hua Jiang, Heather L. Wilson, R.Alan North and Annmarie Surprenant
  The EMBO Journal (2001), 20, - 6347 - 6358, doi:10.1093/emboj/20.22.6347
  - Abstract - Proteomic and functional evidence for a P2X: 7: receptor signalling complex
  - Full text
  - PDF (425 KB) - Proteomic and functional evidence for a P2X: 7: receptor signalling complex
- Modes of spindle pole body inheritance and segregation of the Bfa1p–Bub2p checkpoint protein complex FREE
  Gislene Pereira, Tomoyuki U. Tanaka, Kim Nasmyth and Elmar Schiebel
  The EMBO Journal (2001), 20, - 6359 - 6370, doi:10.1093/emboj/20.22.6359
  - Abstract - Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex
  - Full text
  - PDF (533 KB) - Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex
- Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint FREE
  Lucia Sironi, Marina Melixetian, Mario Faretta, Elena Prosperini, Kristian Helin and Andrea Musacchio
  The EMBO Journal (2001), 20, - 6371 - 6382, doi:10.1093/emboj/20.22.6371
  - Abstract - Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
  - Full text
  - PDF (447 KB) - Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
- The N-terminus of histone H2B, but not that of histone H3 or its phosphorylation, is essential for chromosome condensation FREE
  Anne-Elisabeth de la Barre, Dimitri Angelov, Annie Molla and Stefan Dimitrov
  The EMBO Journal (2001), 20, - 6383 - 6393, doi:10.1093/emboj/20.22.6383
  - Abstract - The N-terminus of histone H2B, but not that of histone H3 or its phosphorylation, is essential for chromosome condensation
  - Full text
  - PDF (397 KB) - The N-terminus of histone H2B, but not that of histone H3 or its phosphorylation, is essential for chromosome condensation
- Stepwise activation of the immunoglobulin heavy chain gene locus FREE
  Dipanjan Chowdhury and Ranjan Sen
  The EMBO Journal (2001), 20, - 6394 - 6403, doi:10.1093/emboj/20.22.6394
  - Abstract - Stepwise activation of the immunoglobulin [mu] heavy chain gene locus
  - Full text
  - PDF (345 KB) - Stepwise activation of the immunoglobulin [mu] heavy chain gene locus
- hADA3 is required for p53 activity FREE
  Ting Wang, Takahiko Kobayashi, Rishu Takimoto, Alec E. Denes, Eric L. Snyder, Wafik S. el-Deiry and Rainer K. Brachmann
  The EMBO Journal (2001), 20, - 6404 - 6413, doi:10.1093/emboj/20.22.6404
  - Abstract - hADA3 is required for p53 activity
  - Full text
  - PDF (395 KB) - hADA3 is required for p53 activity
- Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway FREE
  Hai Wu, Beverly Rothermel, Shane Kanatous, Paul Rosenberg, Francisco J. Naya, John M. Shelton, Kelley A. Hutcheson, J.Michael DiMaio, Eric N. Olson, Rhonda Bassel-Duby and R.Sanders Williams
  The EMBO Journal (2001), 20, - 6414 - 6423, doi:10.1093/emboj/20.22.6414
  - Abstract - Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
  - Full text
  - PDF (380 KB) - Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
- Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex FREE
  Naoyuki Kataoka, Michael D. Diem, V. Narry Kim, Jeongsik Yong and Gideon Dreyfuss
  The EMBO Journal (2001), 20, - 6424 - 6433, doi:10.1093/emboj/20.22.6424
  - Abstract - Magoh, a human homolog of : Drosophila: mago nashi protein, is a component of the splicing-dependent exon-exon junction complex
  - Full text
  - PDF (301 KB) - Magoh, a human homolog of : Drosophila: mago nashi protein, is a component of the splicing-dependent exon-exon junction complex
- Functional involvement of G8 in the hairpin ribozyme cleavage mechanism FREE
  Robert Pinard, Ken J. Hampel, Joyce E. Heckman, Dominic Lambert, Philip A. Chan, Francois Major and John M. Burke
  The EMBO Journal (2001), 20, - 6434 - 6442, doi:10.1093/emboj/20.22.6434
  - Abstract - Functional involvement of G8 in the hairpin ribozyme cleavage mechanism
  - Full text
  - PDF (320 KB) - Functional involvement of G8 in the hairpin ribozyme cleavage mechanism
- Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA FREE
  Catherine Phillips, Stephen Jung and Samuel I. Gunderson
  The EMBO Journal (2001), 20, - 6443 - 6452, doi:10.1093/emboj/20.22.6443
  - Abstract - Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA
  - Full text
  - PDF (350 KB) - Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA
- Physical evidence for distinct mechanisms of translational control by upstream open reading frames FREE
  Anthony Gaba, Zhong Wang, Thanuja Krishnamoorthy, Alan G. Hinnebusch and Matthew S. Sachs
  The EMBO Journal (2001), 20, - 6453 - 6463, doi:10.1093/emboj/20.22.6453
  - Abstract - Physical evidence for distinct mechanisms of translational control by upstream open reading frames
  - Full text
  - PDF (364 KB) - Physical evidence for distinct mechanisms of translational control by upstream open reading frames
- A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols FREE
  Mark P. Ashe, John W. Slaven, Susan K. De Long, Sálma Ibrahimo and Alan B. Sachs
  The EMBO Journal (2001), 20, - 6464 - 6474, doi:10.1093/emboj/20.22.6464
  - Abstract - A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols
  - Full text
  - PDF (338 KB) - A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols
- Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps FREE
  Cosmin Saveanu, David Bienvenu, Abdelkader Namane, Pierre-Emmanuel Gleizes, Nicole Gas, Alain Jacquier and Micheline Fromont-Racine
  The EMBO Journal (2001), 20, - 6475 - 6484, doi:10.1093/emboj/20.22.6475
  - Abstract - Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
  - Full text
  - PDF (421 KB) - Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
- Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression FREE
  Michela Clerici, Vera Paciotti, Veronica Baldo, Michele Romano, Giovanna Lucchini and Maria Pia Longhese
  The EMBO Journal (2001), 20, - 6485 - 6498, doi:10.1093/emboj/20.22.6485
  - Abstract - Hyperactivation of the yeast DNA damage checkpoint by : TEL1: and : DDC2: overexpression
  - Full text
  - PDF (763 KB) - Hyperactivation of the yeast DNA damage checkpoint by : TEL1: and : DDC2: overexpression
- Activation of Cdh1-dependent APC is required for G₁ cell cycle arrest and DNA damage-induced G₂ checkpoint in vertebrate cells FREE
  Tamotsu Sudo, Yosuke Ota, Shuji Kotani, Mitsuyoshi Nakao, Yasunari Takami, Shunichi Takeda and Hideyuki Saya
  The EMBO Journal (2001), 20, - 6499 - 6508, doi:10.1093/emboj/20.22.6499
  - Abstract - Activation of Cdh1-dependent APC is required for G: 1: cell cycle arrest and DNA damage-induced G: 2: checkpoint in vertebrate cells
  - Full text
  - PDF (303 KB) - Activation of Cdh1-dependent APC is required for G: 1: cell cycle arrest and DNA damage-induced G: 2: checkpoint in vertebrate cells
- Topoisomerase II can unlink replicating DNA by precatenane removal FREE
  Isabelle Lucas, Thomas Germe, Marianne Chevrier-Miller and Olivier Hyrien
  The EMBO Journal (2001), 20, - 6509 - 6519, doi:10.1093/emboj/20.22.6509
  - Abstract - Topoisomerase II can unlink replicating DNA by precatenane removal
  - Full text
  - PDF (425 KB) - Topoisomerase II can unlink replicating DNA by precatenane removal
  - Supplementary information
- Unique misinsertion specificity of pol may decrease the mutagenic potential of deaminated cytosines FREE
  Alexandra Vaisman and Roger Woodgate
  The EMBO Journal (2001), 20, - 6520 - 6529, doi:10.1093/emboj/20.22.6520
  - Abstract - Unique misinsertion specificity of pol[iota] may decrease the mutagenic potential of deaminated cytosines
  - Full text
  - PDF (274 KB) - Unique misinsertion specificity of pol[iota] may decrease the mutagenic potential of deaminated cytosines
- XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions FREE
  Antonio E. Vidal, Serge Boiteux, Ian D. Hickson and J. Pablo Radicella
  The EMBO Journal (2001), 20, - 6530 - 6539, doi:10.1093/emboj/20.22.6530
  - Abstract - XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions
  - Full text
  - PDF (282 KB) - XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions
- The structure-specific endonuclease Ercc1–Xpf is required for targeted gene replacement in embryonic stem cells FREE
  Laura J. Niedernhofer, Jeroen Essers, Geert Weeda, Berna Beverloo, Jan de Wit, Manja Muijtjens, Hanny Odijk, Jan H. J. Hoeijmakers and Roland Kanaar
  The EMBO Journal (2001), 20, - 6540 - 6549, doi:10.1093/emboj/20.22.6540
  - Abstract - The structure-specific endonuclease Ercc1–Xpf is required for targeted gene replacement in embryonic stem cells
  - Full text
  - PDF (272 KB) - The structure-specific endonuclease Ercc1–Xpf is required for targeted gene replacement in embryonic stem cells
- Non-homologous end-joining proteins are required for Agrobacterium T-DNA integration FREE
  Haico van Attikum, Paul Bundock and Paul J. J. Hooykaas
  The EMBO Journal (2001), 20, - 6550 - 6558, doi:10.1093/emboj/20.22.6550
  - Abstract - Non-homologous end-joining proteins are required for : Agrobacterium: T-DNA integration
  - Full text
  - PDF (259 KB) - Non-homologous end-joining proteins are required for : Agrobacterium: T-DNA integration

Table of Contents

Volume 20, Number 22 15 November 2001

Medal Review

The beginning of the end FREE

Articles

Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IB protein family FREE

Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture FREE

Molecular mechanisms of -catenin recognition by adenomatous polyposis coli revealed by the structure of an APC–-catenin complex FREE

Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules FREE

Unusual properties of the fungal conventional kinesin neck domain from Neurospora crassa FREE

Strains of [PSI+] are distinguished by their efficiencies of prion-mediated conformational conversion FREE

Apparent genetic redundancy facilitates ecological plasticity for nitrate transport FREE

Competing sorting signals guide endolyn along a novel route to lysosomes in MDCK cells FREE

Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs) FREE

Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca2+ stabilization FREE

Manipulation of oxidative protein folding and PDI redox state in mammalian cells FREE

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53 FREE

Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate FREE

Asymmetrical, agonist-induced fluctuations in local extracellular [Ca2+] in intact polarized epithelia FREE

ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation FREE

ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen FREE

Proteomic and functional evidence for a P2X7 receptor signalling complex FREE

Modes of spindle pole body inheritance and segregation of the Bfa1p–Bub2p checkpoint protein complex FREE

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint FREE

The N-terminus of histone H2B, but not that of histone H3 or its phosphorylation, is essential for chromosome condensation FREE

Stepwise activation of the immunoglobulin heavy chain gene locus FREE

hADA3 is required for p53 activity FREE

Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway FREE

Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex FREE

Functional involvement of G8 in the hairpin ribozyme cleavage mechanism FREE

Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA FREE

Physical evidence for distinct mechanisms of translational control by upstream open reading frames FREE

A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols FREE

Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps FREE

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression FREE

Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells FREE

Topoisomerase II can unlink replicating DNA by precatenane removal FREE

Unique misinsertion specificity of pol may decrease the mutagenic potential of deaminated cytosines FREE

XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions FREE

The structure-specific endonuclease Ercc1–Xpf is required for targeted gene replacement in embryonic stem cells FREE

Non-homologous end-joining proteins are required for Agrobacterium T-DNA integration FREE

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Volume 20, Number 22
15 November 2001

Strains of [PSI⁺] are distinguished by their efficiencies of prion-mediated conformational conversion FREE

Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca²⁺ stabilization FREE

Asymmetrical, agonist-induced fluctuations in local extracellular [Ca²⁺] in intact polarized epithelia FREE

Proteomic and functional evidence for a P2X₇ receptor signalling complex FREE

Activation of Cdh1-dependent APC is required for G₁ cell cycle arrest and DNA damage-induced G₂ checkpoint in vertebrate cells FREE