Table of Contents : The EMBO Journal

Volume 20, Number 21
01 November 2001

pp 5813-6167

Cover. The cover image is an immunofluorescence micrograph of cultured neuroblastoma cells (N2a) incubated with recombinant prion protein fused to GST. Binding of the prion protein was monitored using a monoclonal antibody directed against GST. The punctuate staining shows the binding of the cellular prion protein to its 37-kDa/67-kDa laminin receptor on the cell surface. Christoph Leucht, who recorded this image, is a graduate student in the Weiss laboratory. Corinne Ida Lasmézas is senior scientist at the CEA, Service de Neurovirologie in Fontenay-aux-Roses close to Paris, France. Stefan Weiss is assistant professor at the Gene Center, Institute of Biochemistry in Munich, Germany. For further details see Gauczynski et al., pages 5863--5875 and Hundt et al., pages 5876--5886.

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Articles
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- Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms FREE
  Hartmut H. Niemann, Menno L.W. Knetsch, Anna Scherer, Dietmar J. Manstein and F.Jon Kull
  The EMBO Journal (2001), 20, - 5813 - 5821, doi:10.1093/emboj/20.21.5813
  - Abstract - Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms
  - Full text
  - PDF (401 KB) - Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms
- X-ray structure of the orphan nuclear receptor ROR ligand-binding domain in the active conformation FREE
  Catherine Stehlin, Jean-Marie Wurtz, Anke Steinmetz, Erich Greiner, Roland Schüle, Dino Moras and Jean-Paul Renaud
  The EMBO Journal (2001), 20, - 5822 - 5831, doi:10.1093/emboj/20.21.5822
  - Abstract - X-ray structure of the orphan nuclear receptor ROR[beta] ligand-binding domain in the active conformation
  - Full text
  - PDF (446 KB) - X-ray structure of the orphan nuclear receptor ROR[beta] ligand-binding domain in the active conformation
- Crystal structure of human uroporphyrinogen III synthase FREE
  Michael A.A. Mathews, Heidi L. Schubert, Frank G. Whitby, Kelly J. Alexander, Kevin Schadick, Hector A. Bergonia, John D. Phillips and Christopher P. Hill
  The EMBO Journal (2001), 20, - 5832 - 5839, doi:10.1093/emboj/20.21.5832
  - Abstract - Crystal structure of human uroporphyrinogen III synthase
  - Full text
  - PDF (570 KB) - Crystal structure of human uroporphyrinogen III synthase
- Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells FREE
  Massimo Morra, Jun Lu, Florence Poy, Margarita Martin, Joan Sayos, Silvia Calpe, Charles Gullo, Duncan Howie, Svend Rietdijk, Andrew Thompson, Anthony J. Coyle, Christopher Denny, Michael B. Yaffe, Pablo Engel, Michael J. Eck and Cox Terhorst
  The EMBO Journal (2001), 20, - 5840 - 5852, doi:10.1093/emboj/20.21.5840
  - Abstract - Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells
  - Full text
  - PDF (663 KB) - Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells
- Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein FREE
  Henrik Østergaard, Anette Henriksen, Flemming G. Hansen and Jakob R. Winther
  The EMBO Journal (2001), 20, - 5853 - 5862, doi:10.1093/emboj/20.21.5853
  - Abstract - Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein
  - Full text
  - PDF (355 KB) - Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein
- The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein FREE
  Sabine Gauczynski, Jean-Michel Peyrin, Stéphane Haïk, Christoph Leucht, Christoph Hundt, Roman Rieger, Susanne Krasemann, Jean-Philippe Deslys, Dominique Dormont, Corinne Ida Lasmézas and Stefan Weiss
  The EMBO Journal (2001), 20, - 5863 - 5875, doi:10.1093/emboj/20.21.5863
  - Abstract - The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein
  - Full text
  - PDF (535 KB) - The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein
  - Supplementary information
- Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor FREE
  Christoph Hundt, Jean-Michel Peyrin, Stéphane Haïk, Sabine Gauczynski, Christoph Leucht, Roman Rieger, Maria Louise Riley, Jean-Philippe Deslys, Dominique Dormont, Corinne Ida Lasmézas and Stefan Weiss
  The EMBO Journal (2001), 20, - 5876 - 5886, doi:10.1093/emboj/20.21.5876
  - Abstract - Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor
  - Full text
  - PDF (352 KB) - Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor
- Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses FREE
  Matthias Hartmann, Rolf Heumann and Volkmar Lessmann
  The EMBO Journal (2001), 20, - 5887 - 5897, doi:10.1093/emboj/20.21.5887
  - Abstract - Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses
  - Full text
  - PDF (492 KB) - Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses
- Immunoproteasome assembly and antigen presentation in mice lacking both PA28 and PA28 FREE
  Shigeo Murata, Heiichiro Udono, Nobuyuki Tanahashi, Nobuyuki Hamada, Ken Watanabe, Kei Adachi, Taketoshi Yamano, Katsuyuki Yui, Nobuyuki Kobayashi, Masanori Kasahara, Keiji Tanaka and Tomoki Chiba
  The EMBO Journal (2001), 20, - 5898 - 5907, doi:10.1093/emboj/20.21.5898
  - Abstract - Immunoproteasome assembly and antigen presentation in mice lacking both PA28[alpha] and PA28[beta]
  - Full text
  - PDF (375 KB) - Immunoproteasome assembly and antigen presentation in mice lacking both PA28[alpha] and PA28[beta]
- EcfE, a new essential inner membrane protease: its role in the regulation of heat shock response in Escherichia coli FREE
  Claire Dartigalongue, Hannes Loferer and Satish Raina
  The EMBO Journal (2001), 20, - 5908 - 5918, doi:10.1093/emboj/20.21.5908
  - Abstract - EcfE, a new essential inner membrane protease: its role in the regulation of heat shock response in : Escherichia coli
  - Full text
  - PDF (337 KB) - EcfE, a new essential inner membrane protease: its role in the regulation of heat shock response in : Escherichia coli
- Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak FREE
  Zubin Master, Nina Jones, Jennifer Tran, Jamie Jones, Robert S. Kerbel and Daniel J. Dumont
  The EMBO Journal (2001), 20, - 5919 - 5928, doi:10.1093/emboj/20.21.5919
  - Abstract - Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak
  - Full text
  - PDF (301 KB) - Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak
- Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells FREE
  Rina Rosin-Arbesfeld, Gudrun Ihrke and Mariann Bienz
  The EMBO Journal (2001), 20, - 5929 - 5939, doi:10.1093/emboj/20.21.5929
  - Abstract - Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells
  - Full text
  - PDF (657 KB) - Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells
  - Supplementary information
- Cystinosin, the protein defective in cystinosis, is a H⁺-driven lysosomal cystine transporter FREE
  Vasiliki Kalatzis, Stéphanie Cherqui, Corinne Antignac and Bruno Gasnier
  The EMBO Journal (2001), 20, - 5940 - 5949, doi:10.1093/emboj/20.21.5940
  - Abstract - Cystinosin, the protein defective in cystinosis, is a H: +: -driven lysosomal cystine transporter
  - Full text
  - PDF (320 KB) - Cystinosin, the protein defective in cystinosis, is a H: +: -driven lysosomal cystine transporter
- Identification of an axonal determinant in the C-terminus of the sodium channel Na_v1.2 FREE
  Juan José Garrido, Fanny Fernandes, Pierre Giraud, Isabelle Mouret, Eric Pasqualini, Marie-Pierre Fache, Florence Jullien and Bénédicte Dargent
  The EMBO Journal (2001), 20, - 5950 - 5961, doi:10.1093/emboj/20.21.5950
  - Abstract - Identification of an axonal determinant in the C-terminus of the sodium channel Na: v: 1.2
  - Full text
  - PDF (547 KB) - Identification of an axonal determinant in the C-terminus of the sodium channel Na: v: 1.2
- The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporter FREE
  Hiroki Nagai and Craig R. Roy
  The EMBO Journal (2001), 20, - 5962 - 5970, doi:10.1093/emboj/20.21.5962
  - Abstract - The DotA protein from : Legionella pneumophila: is secreted by a novel process that requires the Dot/Icm transporter
  - Full text
  - PDF (229 KB) - The DotA protein from : Legionella pneumophila: is secreted by a novel process that requires the Dot/Icm transporter
- The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation FREE
  Kuninori Suzuki, Takayoshi Kirisako, Yoshiaki Kamada, Noboru Mizushima, Takeshi Noda and Yoshinori Ohsumi
  The EMBO Journal (2001), 20, - 5971 - 5981, doi:10.1093/emboj/20.21.5971
  - Abstract - The pre-autophagosomal structure organized by concerted functions of : APG: genes is essential for autophagosome formation
  - Full text
  - PDF (355 KB) - The pre-autophagosomal structure organized by concerted functions of : APG: genes is essential for autophagosome formation
- Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain FREE
  Yusuke Maeda, Galina V. Beznoussenko, Johan Van Lint, Alexander A. Mironov and Vivek Malhotra
  The EMBO Journal (2001), 20, - 5982 - 5990, doi:10.1093/emboj/20.21.5982
  - Abstract - Recruitment of protein kinase D to the : trans: -Golgi network via the first cysteine-rich domain
  - Full text
  - PDF (356 KB) - Recruitment of protein kinase D to the : trans: -Golgi network via the first cysteine-rich domain
- An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes FREE
  Symeon Siniossoglou and Hugh R.B. Pelham
  The EMBO Journal (2001), 20, - 5991 - 5998, doi:10.1093/emboj/20.21.5991
  - Abstract - An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes
  - Full text
  - PDF (263 KB) - An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes
- Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis FREE
  Weijia Zhu, Brian Leber and David W. Andrews
  The EMBO Journal (2001), 20, - 5999 - 6007, doi:10.1093/emboj/20.21.5999
  - Abstract - Cytoplasmic : O: -glycosylation prevents cell surface transport of E-cadherin during apoptosis
  - Full text
  - PDF (283 KB) - Cytoplasmic : O: -glycosylation prevents cell surface transport of E-cadherin during apoptosis
- The vasorelaxant effect of H₂S as a novel endogenous gaseous K_ATP channel opener FREE
  Weimin Zhao, Jing Zhang, Yanjie Lu and Rui Wang
  The EMBO Journal (2001), 20, - 6008 - 6016, doi:10.1093/emboj/20.21.6008
  - Abstract - The vasorelaxant effect of H: 2: S as a novel endogenous gaseous K: ATP: channel opener
  - Full text
  - PDF (329 KB) - The vasorelaxant effect of H: 2: S as a novel endogenous gaseous K: ATP: channel opener
- A Dictyostelium nuclear phosphatidylinositol phosphate kinase required for developmental gene expression FREE
  Kunde Guo, Richard Nichol, Paul Skehel, Dirk Dormann, Cornelis J. Weijer, Jeffrey G. Williams and Catherine Pears
  The EMBO Journal (2001), 20, - 6017 - 6027, doi:10.1093/emboj/20.21.6017
  - Abstract - A : Dictyostelium: nuclear phosphatidylinositol phosphate kinase required for developmental gene expression
  - Full text
  - PDF (619 KB) - A : Dictyostelium: nuclear phosphatidylinositol phosphate kinase required for developmental gene expression
- Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress FREE
  Kei-ichi Morita, Masao Saitoh, Kei Tobiume, Hiroshi Matsuura, Shoji Enomoto, Hideki Nishitoh and Hidenori Ichijo
  The EMBO Journal (2001), 20, - 6028 - 6036, doi:10.1093/emboj/20.21.6028
  - Abstract - Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
  - Full text
  - PDF (290 KB) - Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
- Two mechanisms activate PTP during mitosis FREE
  Xin-Min Zheng and David Shalloway
  The EMBO Journal (2001), 20, - 6037 - 6049, doi:10.1093/emboj/20.21.6037
  - Abstract - Two mechanisms activate PTP[alpha] during mitosis
  - Full text
  - PDF (303 KB) - Two mechanisms activate PTP[alpha] during mitosis
- PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells FREE
  Gabriella Castoria, Antimo Migliaccio, Antonio Bilancio, Marina Di Domenico, Antonietta de Falco, Maria Lombardi, Roberto Fiorentino, Lilian Varricchio, Maria Vittoria Barone and Ferdinando Auricchio
  The EMBO Journal (2001), 20, - 6050 - 6059, doi:10.1093/emboj/20.21.6050
  - Abstract - PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells
  - Full text
  - PDF (272 KB) - PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells
- Mechanism for the switch of 29 DNA early to late transcription by regulatory protein p4 and histone-like protein p6 FREE
  Ana Camacho and Margarita Salas
  The EMBO Journal (2001), 20, - 6060 - 6070, doi:10.1093/emboj/20.21.6060
  - Abstract - Mechanism for the switch of [phgr]29 DNA early to late transcription by regulatory protein p4 and histone-like protein p6
  - Full text
  - PDF (432 KB) - Mechanism for the switch of [phgr]29 DNA early to late transcription by regulatory protein p4 and histone-like protein p6
- Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones FREE
  Inez Rogatsky, Kol A. Zarember and Keith R. Yamamoto
  The EMBO Journal (2001), 20, - 6071 - 6083, doi:10.1093/emboj/20.21.6071
  - Abstract - Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones
  - Full text
  - PDF (369 KB) - Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones
- A role for coactivators and histone acetylation in estrogen receptor -mediated transcription initiation FREE
  Mi Young Kim, Susan J. Hsiao and W. Lee Kraus
  The EMBO Journal (2001), 20, - 6084 - 6094, doi:10.1093/emboj/20.21.6084
  - Abstract - A role for coactivators and histone acetylation in estrogen receptor [alpha]-mediated transcription initiation
  - Full text
  - PDF (375 KB) - A role for coactivators and histone acetylation in estrogen receptor [alpha]-mediated transcription initiation
- A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300 FREE
  Robert G.J. Vries, Michela Prudenziati, Carin Zwartjes, Matty Verlaan, Eric Kalkhoven and Alt Zantema
  The EMBO Journal (2001), 20, - 6095 - 6103, doi:10.1093/emboj/20.21.6095
  - Abstract - A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300
  - Full text
  - PDF (257 KB) - A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300
- Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo FREE
  Mark Gerber, Jiyan Ma, Kimberly Dean, Joel C. Eissenberg and Ali Shilatifard
  The EMBO Journal (2001), 20, - 6104 - 6114, doi:10.1093/emboj/20.21.6104
  - Abstract - Drosophila: ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites : in vivo
  - Full text
  - PDF (481 KB) - Drosophila: ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites : in vivo
- Regulation of replication timing in fission yeast FREE
  Soo-Mi Kim and Joel A. Huberman
  The EMBO Journal (2001), 20, - 6115 - 6126, doi:10.1093/emboj/20.21.6115
  - Abstract - Regulation of replication timing in fission yeast
  - Full text
  - PDF (478 KB) - Regulation of replication timing in fission yeast
- Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination FREE
  Nathalie Grandin, Christelle Damon and Michel Charbonneau
  The EMBO Journal (2001), 20, - 6127 - 6139, doi:10.1093/emboj/20.21.6127
  - Abstract - Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination
  - Full text
  - PDF (492 KB) - Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination
  - Supplementary information
- Clue to damage recognition by UvrB: residues in the -hairpin structure prevent binding to non-damaged DNA FREE
  Geri F. Moolenaar, Lotta Höglund and Nora Goosen
  The EMBO Journal (2001), 20, - 6140 - 6149, doi:10.1093/emboj/20.21.6140
  - Abstract - Clue to damage recognition by UvrB: residues in the [beta]-hairpin structure prevent binding to non-damaged DNA
  - Full text
  - PDF (346 KB) - Clue to damage recognition by UvrB: residues in the [beta]-hairpin structure prevent binding to non-damaged DNA
- Developmental regulation of DNA replication timing at the human globin locus FREE
  Itamar Simon, Toyoaki Tenzen, Raul Mostoslavsky, Eitan Fibach, Laura Lande, Eric Milot, Joost Gribnau, Frank Grosveld, Peter Fraser and Howard Cedar
  The EMBO Journal (2001), 20, - 6150 - 6157, doi:10.1093/emboj/20.21.6150
  - Abstract - Developmental regulation of DNA replication timing at the human [beta] globin locus
  - Full text
  - PDF (220 KB) - Developmental regulation of DNA replication timing at the human [beta] globin locus
- DNA forms indicate rolling circle and recombination-dependent replication of Abutilon mosaic virus FREE
  Holger Jeske, Martin Lütgemeier and Werner Prei
  The EMBO Journal (2001), 20, - 6158 - 6167, doi:10.1093/emboj/20.21.6158
  - Abstract - DNA forms indicate rolling circle and recombination-dependent replication of : Abutilon: mosaic virus
  - Full text
  - PDF (516 KB) - DNA forms indicate rolling circle and recombination-dependent replication of : Abutilon: mosaic virus

Table of Contents

Volume 20, Number 21 01 November 2001

Articles

Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms FREE

X-ray structure of the orphan nuclear receptor ROR ligand-binding domain in the active conformation FREE

Crystal structure of human uroporphyrinogen III synthase FREE

Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells FREE

Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein FREE

The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein FREE

Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor FREE

Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses FREE

Immunoproteasome assembly and antigen presentation in mice lacking both PA28 and PA28 FREE

EcfE, a new essential inner membrane protease: its role in the regulation of heat shock response in Escherichia coli FREE

Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak FREE

Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells FREE

Cystinosin, the protein defective in cystinosis, is a H+-driven lysosomal cystine transporter FREE

Identification of an axonal determinant in the C-terminus of the sodium channel Nav1.2 FREE

The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporter FREE

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation FREE

Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain FREE

An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes FREE

Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis FREE

The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener FREE

A Dictyostelium nuclear phosphatidylinositol phosphate kinase required for developmental gene expression FREE

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress FREE

Two mechanisms activate PTP during mitosis FREE

PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells FREE

Mechanism for the switch of 29 DNA early to late transcription by regulatory protein p4 and histone-like protein p6 FREE

Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones FREE

A role for coactivators and histone acetylation in estrogen receptor -mediated transcription initiation FREE

A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300 FREE

Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo FREE

Regulation of replication timing in fission yeast FREE

Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination FREE

Clue to damage recognition by UvrB: residues in the -hairpin structure prevent binding to non-damaged DNA FREE

Developmental regulation of DNA replication timing at the human globin locus FREE

DNA forms indicate rolling circle and recombination-dependent replication of Abutilon mosaic virus FREE

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Volume 20, Number 21
01 November 2001

Cystinosin, the protein defective in cystinosis, is a H⁺-driven lysosomal cystine transporter FREE

Identification of an axonal determinant in the C-terminus of the sodium channel Na_v1.2 FREE

The vasorelaxant effect of H₂S as a novel endogenous gaseous K_ATP channel opener FREE