Table of Contents : The EMBO Journal

Volume 20, Number 13
02 July 2001

pp 3293-3607

Cover. Sometimes it feels as though everything is connected (2000), original oil painting (120 x 60 cm) by Michael Dye. The artist is a post-doc at the Sir William Dunn School of Pathology, Oxford, UK. He studies the interconnection between RNA processing and transcription.

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New EMBO Members Review
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- Control of chromosomal DNA replication in the early Xenopus embryo FREE
  J.Julian Blow
  The EMBO Journal (2001), 20, - 3293 - 3297, doi:10.1093/emboj/20.13.3293
  - Full text
  - PDF (156 KB) - Control of chromosomal DNA replication in the early : Xenopus: embryo
- Nuclear interpretation of Dpp signaling in Drosophila FREE
  Markus Affolter, Thomas Marty, M. Alessandra Vigano and Anna Jawiska
  The EMBO Journal (2001), 20, - 3298 - 3305, doi:10.1093/emboj/20.13.3298
Articles
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- Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence FREE
  Karin Petersson, Maria Håkansson, Helen Nilsson, Göran Forsberg, L. Anders Svensson, Anders Liljas and Björn Walse
  The EMBO Journal (2001), 20, - 3306 - 3312, doi:10.1093/emboj/20.13.3306
  - Abstract - Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence
  - Full text
  - PDF (409 KB) - Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence
- Three-dimensional structure of the lithostathine protofibril, a protein involved in Alzheimer's disease FREE
  Catherine Grégoire, Sergio Marco, Jean Thimonier, Laure Duplan, Emmanuelle Laurine, Jean-Paul Chauvin, Bernard Michel, Vincent Peyrot and Jean-Michel Verdier
  The EMBO Journal (2001), 20, - 3313 - 3321, doi:10.1093/emboj/20.13.3313
  - Abstract - Three-dimensional structure of the lithostathine protofibril, a protein involved in Alzheimer's disease
  - Full text
  - PDF (419 KB) - Three-dimensional structure of the lithostathine protofibril, a protein involved in Alzheimer's disease
- Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors FREE
  Terry K. Smith, Arthur Crossman, Charles N. Borissow, Michael J. Paterson, Alex Dix, John S. Brimacombe and Michael A.J. Ferguson
  The EMBO Journal (2001), 20, - 3322 - 3332, doi:10.1093/emboj/20.13.3322
  - Abstract - Specificity of GlcNAc-PI de-: N: -acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors
  - Full text
  - PDF (404 KB) - Specificity of GlcNAc-PI de-: N: -acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors
- Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis FREE
  Yusuke Ohba, Koichi Ikuta, Atsuo Ogura, Junichiro Matsuda, Naoki Mochizuki, Kazuo Nagashima, Kazuo Kurokawa, Bruce J. Mayer, Kazushige Maki, Jun-ichi Miyazaki and Michiyuki Matsuda
  The EMBO Journal (2001), 20, - 3333 - 3341, doi:10.1093/emboj/20.13.3333
  - Abstract - Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis
  - Full text
  - PDF (339 KB) - Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis
  - Supplementary information
- N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration FREE
  Eiichiro Nishi, Annik Prat, Véronique Hospital, Klaus Elenius and Michael Klagsbrun
  The EMBO Journal (2001), 20, - 3342 - 3350, doi:10.1093/emboj/20.13.3342
  - Abstract - N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration
  - Full text
  - PDF (270 KB) - N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration
- Scrapie strains maintain biological phenotypes on propagation in a cell line in culture FREE
  Christopher R. Birkett, Ruth M. Hennion, Dawn A. Bembridge, Michael C. Clarke, Aileen Chree, Moira E. Bruce and Christopher J. Bostock
  The EMBO Journal (2001), 20, - 3351 - 3358, doi:10.1093/emboj/20.13.3351
  - Abstract - Scrapie strains maintain biological phenotypes on propagation in a cell line in culture
  - Full text
  - PDF (284 KB) - Scrapie strains maintain biological phenotypes on propagation in a cell line in culture
- Lysine 188 substitutions convert the pattern of proteasome activation by REG to that of REGs and FREE
  Jun Li, Xiaolin Gao, Joaquin Ortega, Tamim Nazif, Lisa Joss, Matthew Bogyo, Alasdair C. Steven and Martin Rechsteiner
  The EMBO Journal (2001), 20, - 3359 - 3369, doi:10.1093/emboj/20.13.3359
  - Abstract - Lysine 188 substitutions convert the pattern of proteasome activation by REG[gamma] to that of REGs [alpha] and [beta]
  - Full text
  - PDF (606 KB) - Lysine 188 substitutions convert the pattern of proteasome activation by REG[gamma] to that of REGs [alpha] and [beta]
  - Supplementary information
- Analysis of heterodimer formation by Xklp3A/B, a newly cloned kinesin-II from Xenopus laevis FREE
  Valeria De Marco, Peter Burkhard, Nathalie Le Bot, Isabelle Vernos and Andreas Hoenger
  The EMBO Journal (2001), 20, - 3370 - 3379, doi:10.1093/emboj/20.13.3370
  - Abstract - Analysis of heterodimer formation by Xklp3A/B, a newly cloned kinesin-II from : Xenopus laevis
  - Full text
  - PDF (570 KB) - Analysis of heterodimer formation by Xklp3A/B, a newly cloned kinesin-II from : Xenopus laevis
- Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation FREE
  Nia J. Bryant and David E. James
  The EMBO Journal (2001), 20, - 3380 - 3388, doi:10.1093/emboj/20.13.3380
  - Abstract - Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation
  - Full text
  - PDF (242 KB) - Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation
- Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint FREE
  Miguel Angel Garcia, Leah Vardy, Nirada Koonrugsa and Takashi Toda
  The EMBO Journal (2001), 20, - 3389 - 3401, doi:10.1093/emboj/20.13.3389
  - Abstract - Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint
  - Full text
  - PDF (594 KB) - Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint
  - Supplementary information
- Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system FREE
  Marta M. Lipinski, Kay F. Macleod, Bart O. Williams, Tara L. Mullaney, Denise Crowley and Tyler Jacks
  The EMBO Journal (2001), 20, - 3402 - 3413, doi:10.1093/emboj/20.13.3402
  - Abstract - Cell-autonomous and non-cell-autonomous functions of the : Rb: tumor suppressor in developing central nervous system
  - Full text
  - PDF (461 KB) - Cell-autonomous and non-cell-autonomous functions of the : Rb: tumor suppressor in developing central nervous system
  - Supplementary information
- PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates FREE
  Dominique Davidson and André Veillette
  The EMBO Journal (2001), 20, - 3414 - 3426, doi:10.1093/emboj/20.13.3414
  - Abstract - PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates
  - Full text
  - PDF (414 KB) - PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates
- Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation FREE
  Annapoorni Rangarajan, Claudio Talora, Ryuhei Okuyama, Michael Nicolas, Cristina Mammucari, Heysun Oh, Jon C. Aster, Sudhir Krishna, Daniel Metzger, Pierre Chambon, Lucio Miele, Michel Aguet, Freddy Radtke and G.Paolo Dotto
  The EMBO Journal (2001), 20, - 3427 - 3436, doi:10.1093/emboj/20.13.3427
  - Abstract - Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
  - Full text
  - PDF (365 KB) - Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
  - Supplementary information
- A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation FREE
  Stephen E. Girardin and Moshe Yaniv
  The EMBO Journal (2001), 20, - 3437 - 3446, doi:10.1093/emboj/20.13.3437
  - Abstract - A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation
  - Full text
  - PDF (310 KB) - A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation
- Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components FREE
  Deepak Nihalani, Debra Meyer, Sangeeta Pajni and Lawrence B. Holzman
  The EMBO Journal (2001), 20, - 3447 - 3458, doi:10.1093/emboj/20.13.3447
  - Abstract - Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components
  - Full text
  - PDF (388 KB) - Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components
- Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1 FREE
  Gerburg M. Wulf, Akihide Ryo, Gerald G. Wulf, Sam W. Lee, Tianhua Niu, Victoria Petkova and Kun Ping Lu
  The EMBO Journal (2001), 20, - 3459 - 3472, doi:10.1093/emboj/20.13.3459
  - Abstract - Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1
  - Full text
  - PDF (609 KB) - Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1
- The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p FREE
  Kim E. Williams and Martha S. Cyert
  The EMBO Journal (2001), 20, - 3473 - 3483, doi:10.1093/emboj/20.13.3473
  - Abstract - The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p
  - Full text
  - PDF (253 KB) - The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p
- Rsk2 allosterically activates estrogen receptor by docking to the hormone-binding domain FREE
  David E. Clark, Celeste E. Poteet-Smith, Jeffrey A. Smith and Deborah A. Lannigan
  The EMBO Journal (2001), 20, - 3484 - 3494, doi:10.1093/emboj/20.13.3484
  - Abstract - Rsk2 allosterically activates estrogen receptor [alpha] by docking to the hormone-binding domain
  - Full text
  - PDF (424 KB) - Rsk2 allosterically activates estrogen receptor [alpha] by docking to the hormone-binding domain
- PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator FREE
  Tarik Regad, Ali Saib, Valérie Lallemand-Breitenbach, Pier Paolo Pandolfi, Hugues de Thé and Mounira K. Chelbi-Alix
  The EMBO Journal (2001), 20, - 3495 - 3505, doi:10.1093/emboj/20.13.3495
  - Abstract - PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator
  - Full text
  - PDF (326 KB) - PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator
- Spt16–Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN FREE
  Tim Formosa, Peter Eriksson, Jacqui Wittmeyer, Jennifer Ginn, Yaxin Yu and David J. Stillman
  The EMBO Journal (2001), 20, - 3506 - 3517, doi:10.1093/emboj/20.13.3506
  - Abstract - Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN
  - Full text
  - PDF (379 KB) - Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN
- An upstream repressor element plays a role in Igf2 imprinting FREE
  Sharon Eden, Miguel Constancia, Tamar Hashimshony, Wendy Dean, Beth Goldstein, Alfred C. Johnson, Ilana Keshet, Wolf Reik and Howard Cedar
  The EMBO Journal (2001), 20, - 3518 - 3525, doi:10.1093/emboj/20.13.3518
  - Abstract - An upstream repressor element plays a role in : Igf2: imprinting
  - Full text
  - PDF (228 KB) - An upstream repressor element plays a role in : Igf2: imprinting
- Human telomerase contains two cooperating telomerase RNA molecules FREE
  Christian Wenz, Barbara Enenkel, Mario Amacker, Colleen Kelleher, Klaus Damm and Joachim Lingner
  The EMBO Journal (2001), 20, - 3526 - 3534, doi:10.1093/emboj/20.13.3526
  - Abstract - Human telomerase contains two cooperating telomerase RNA molecules
  - Full text
  - PDF (325 KB) - Human telomerase contains two cooperating telomerase RNA molecules
- Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice FREE
  Carmen Conde, Manuel Mark, F.Javier Oliver, Aline Huber, Gilbert de Murcia and Josiane Ménissier-de Murcia
  The EMBO Journal (2001), 20, - 3535 - 3543, doi:10.1093/emboj/20.13.3535
  - Abstract - Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
  - Full text
  - PDF (304 KB) - Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
- The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage FREE
  Xiaolan Zhao, Andrei Chabes, Vladimir Domkin, Lars Thelander and Rodney Rothstein
  The EMBO Journal (2001), 20, - 3544 - 3553, doi:10.1093/emboj/20.13.3544
  - Abstract - The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
  - Full text
  - PDF (315 KB) - The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
- Double-check probing of DNA bending and unwinding by XPA–RPA: an architectural function in DNA repair FREE
  Miriam Missura, Tonko Buterin, Robert Hindges, Ulrich Hübscher, Jana Kaspárková, Viktor Brabec and Hanspeter Naegeli
  The EMBO Journal (2001), 20, - 3554 - 3564, doi:10.1093/emboj/20.13.3554
  - Abstract - Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair
  - Full text
  - PDF (398 KB) - Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair
- Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes FREE
  Kui Gao, Scott L. Butler and Frederic Bushman
  The EMBO Journal (2001), 20, - 3565 - 3576, doi:10.1093/emboj/20.13.3565
  - Abstract - Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes
  - Full text
  - PDF (427 KB) - Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes
- Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing FREE
  Timothy S. McConnell and Joan A. Steitz
  The EMBO Journal (2001), 20, - 3577 - 3586, doi:10.1093/emboj/20.13.3577
  - Abstract - Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing
  - Full text
  - PDF (340 KB) - Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing
- Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli FREE
  Keiko Kimata, Yuya Tanaka, Toshifumi Inada and Hiroji Aiba
  The EMBO Journal (2001), 20, - 3587 - 3595, doi:10.1093/emboj/20.13.3587
  - Abstract - Expression of the glucose transporter gene, : ptsG: , is regulated at the mRNA degradation step in response to glycolytic flux in : Escherichia coli
  - Full text
  - PDF (256 KB) - Expression of the glucose transporter gene, : ptsG: , is regulated at the mRNA degradation step in response to glycolytic flux in : Escherichia coli
- VIP1, an Arabidopsis protein that interacts with Agrobacterium VirE2, is involved in VirE2 nuclear import and Agrobacterium infectivity FREE
  Tzvi Tzfira, Manjusha Vaidya and Vitaly Citovsky
  The EMBO Journal (2001), 20, - 3596 - 3607, doi:10.1093/emboj/20.13.3596
  - Abstract - VIP1, an : Arabidopsis: protein that interacts with : Agrobacterium: VirE2, is involved in VirE2 nuclear import and : Agrobacterium: infectivity
  - Full text
  - PDF (454 KB) - VIP1, an : Arabidopsis: protein that interacts with : Agrobacterium: VirE2, is involved in VirE2 nuclear import and : Agrobacterium: infectivity

Table of Contents

Volume 20, Number 13 02 July 2001

New EMBO Members Review

Control of chromosomal DNA replication in the early Xenopus embryo FREE

Nuclear interpretation of Dpp signaling in Drosophila FREE

Articles

Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence FREE

Three-dimensional structure of the lithostathine protofibril, a protein involved in Alzheimer's disease FREE

Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors FREE

Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis FREE

N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration FREE

Scrapie strains maintain biological phenotypes on propagation in a cell line in culture FREE

Lysine 188 substitutions convert the pattern of proteasome activation by REG to that of REGs and FREE

Analysis of heterodimer formation by Xklp3A/B, a newly cloned kinesin-II from Xenopus laevis FREE

Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation FREE

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint FREE

Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system FREE

PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates FREE

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation FREE

A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation FREE

Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components FREE

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1 FREE

The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p FREE

Rsk2 allosterically activates estrogen receptor by docking to the hormone-binding domain FREE

PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator FREE

Spt16–Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN FREE

An upstream repressor element plays a role in Igf2 imprinting FREE

Human telomerase contains two cooperating telomerase RNA molecules FREE

Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice FREE

The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage FREE

Double-check probing of DNA bending and unwinding by XPA–RPA: an architectural function in DNA repair FREE

Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes FREE

Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing FREE

Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli FREE

VIP1, an Arabidopsis protein that interacts with Agrobacterium VirE2, is involved in VirE2 nuclear import and Agrobacterium infectivity FREE

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Volume 20, Number 13
02 July 2001