Table of Contents : The EMBO Journal

Volume 19, Number 22
15 November 2000

pp 5943-6284

Cover. A ribbon diagram of the human Xrcc4 dimer. Xrcc4 forms a stable complex with DNA ligase IV and is essential for non-homolous end-joining in DNA double-strand break repair. Knock-out of xrcc4 in mice results in embryonic lethality. Wei Yang is a senior investigator at National Institutes of Health. Her group studies structure and mechanism of DNA repair. For further details see Junop et al., pp. 5962--5970 and also http://www-mslmb.niddk.nih.gov/yanggroup.html

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New EMBO Members Review
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- Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives FREE
  K. Sandvig and B. van Deurs
  The EMBO Journal (2000), 19, - 5943 - 5950, doi:10.1093/emboj/19.22.5943
Articles
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- Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis FREE
  Kay Diederichs, Joachim Diez, Gerhard Greller, Christian Müller, Jason Breed, Christoph Schnell, Clemens Vonrhein, Winfried Boos and Wolfram Welte
  The EMBO Journal (2000), 19, - 5951 - 5961, doi:10.1093/emboj/19.22.5951
  - Abstract - Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon : Thermococcus litoralis
  - Full text
  - PDF (1,057 KB) - Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon : Thermococcus litoralis
- Crystal structure of the Xrcc4 DNA repair protein and implications for end joining FREE
  Murray S. Junop, Mauro Modesti, Alba Guarné, Rodolfo Ghirlando, Martin Gellert and Wei Yang
  The EMBO Journal (2000), 19, - 5962 - 5970, doi:10.1093/emboj/19.22.5962
  - Abstract - Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
  - Full text
  - PDF (1,136 KB) - Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
- Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations FREE
  Oscar Llorca, Jaime Martín-Benito, Monica Ritco-Vonsovici, Julie Grantham, Gillian M. Hynes, Keith R. Willison, José L. Carrascosa and José M. Valpuesta
  The EMBO Journal (2000), 19, - 5971 - 5979, doi:10.1093/emboj/19.22.5971
  - Abstract - Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations
  - Full text
  - PDF (921 KB) - Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations
- Protein folding in the periplasm in the absence of primary oxidant DsbA: modulation of redox potential in periplasmic space via OmpL porin FREE
  Claire Dartigalongue, Hiroshi Nikaido and Satish Raina
  The EMBO Journal (2000), 19, - 5980 - 5988, doi:10.1093/emboj/19.22.5980
  - Abstract - Protein folding in the periplasm in the absence of primary oxidant DsbA: modulation of redox potential in periplasmic space via OmpL porin
  - Full text
  - PDF (307 KB) - Protein folding in the periplasm in the absence of primary oxidant DsbA: modulation of redox potential in periplasmic space via OmpL porin
- Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins FREE
  Egbert Hoiczyk, Andreas Roggenkamp, Marisa Reichenbecher, Andrei Lupas and Jürgen Heesemann
  The EMBO Journal (2000), 19, - 5989 - 5999, doi:10.1093/emboj/19.22.5989
  - Abstract - Structure and sequence analysis of : Yersinia: YadA and : Moraxella: UspAs reveal a novel class of adhesins
  - Full text
  - PDF (1,193 KB) - Structure and sequence analysis of : Yersinia: YadA and : Moraxella: UspAs reveal a novel class of adhesins
- Exocytosis requires asymmetry in the central layer of the SNARE complex FREE
  Rainer Ossig, Hans Dieter Schmitt, Bert de Groot, Dietmar Riedel, Sirkka Keränen, Hans Ronne, Helmut Grubmüller and Reinhard Jahn
  The EMBO Journal (2000), 19, - 6000 - 6010, doi:10.1093/emboj/19.22.6000
  - Abstract - Exocytosis requires asymmetry in the central layer of the SNARE complex
  - Full text
  - PDF (901 KB) - Exocytosis requires asymmetry in the central layer of the SNARE complex
- Dual interaction of synaptotagmin with 2- and -adaptin facilitates clathrin-coated pit nucleation FREE
  Volker Haucke, Markus R. Wenk, Edwin R. Chapman, Khashayar Farsad and Pietro De Camilli
  The EMBO Journal (2000), 19, - 6011 - 6019, doi:10.1093/emboj/19.22.6011
  - Abstract - Dual interaction of synaptotagmin with [mu]2- and [alpha]-adaptin facilitates clathrin-coated pit nucleation
  - Full text
  - PDF (570 KB) - Dual interaction of synaptotagmin with [mu]2- and [alpha]-adaptin facilitates clathrin-coated pit nucleation
- Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin–catenins complex FREE
  Polonca Küssel-Andermann, Aziz El-Amraoui, Saaid Safieddine, Sylvie Nouaille, Isabelle Perfettini, Marc Lecuit, Pascale Cossart, Uwe Wolfrum and Christine Petit
  The EMBO Journal (2000), 19, - 6020 - 6029, doi:10.1093/emboj/19.22.6020
  - Abstract - Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex
  - Full text
  - PDF (1,301 KB) - Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex
- Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei: the time bomb theory of ookinete invasion of mosquitoes FREE
  Yeon Soo Han, Joanne Thompson, Fotis C. Kafatos and Carolina Barillas-Mury
  The EMBO Journal (2000), 19, - 6030 - 6040, doi:10.1093/emboj/19.22.6030
  - Abstract - Molecular interactions between : Anopheles stephensi: midgut cells and : Plasmodium berghei: : the time bomb theory of ookinete invasion of mosquitoes
  - Full text
  - PDF (1,154 KB) - Molecular interactions between : Anopheles stephensi: midgut cells and : Plasmodium berghei: : the time bomb theory of ookinete invasion of mosquitoes
- Signal transduction to the Azotobacter vinelandii NIFL–NIFA regulatory system is influenced directly by interaction with 2-oxoglutarate and the PII regulatory protein FREE
  Richard Little, Francisca Reyes-Ramirez, Yan Zhang, Wally C. van Heeswijk and Ray Dixon
  The EMBO Journal (2000), 19, - 6041 - 6050, doi:10.1093/emboj/19.22.6041
  - Abstract - Signal transduction to the : Azotobacter vinelandii: NIFL-NIFA regulatory system is influenced directly by interaction with 2-oxoglutarate and the PII regulatory protein
  - Full text
  - PDF (378 KB) - Signal transduction to the : Azotobacter vinelandii: NIFL-NIFA regulatory system is influenced directly by interaction with 2-oxoglutarate and the PII regulatory protein
- Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells FREE
  Sagar Sengupta, Jean-Luc Vonesch, Caroline Waltzinger, Hong Zheng and Bohdan Wasylyk
  The EMBO Journal (2000), 19, - 6051 - 6064, doi:10.1093/emboj/19.22.6051
  - Abstract - Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells
  - Full text
  - PDF (1,072 KB) - Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells
- Mos activates MAP kinase in mouse oocytes through two opposite pathways FREE
  Marie-Hélène Verlhac, Christophe Lefebvre, Jacek Z. Kubiak, Muriel Umbhauer, Pascale Rassinier, William Colledge and Bernard Maro
  The EMBO Journal (2000), 19, - 6065 - 6074, doi:10.1093/emboj/19.22.6065
  - Abstract - Mos activates MAP kinase in mouse oocytes through two opposite pathways
  - Full text
  - PDF (610 KB) - Mos activates MAP kinase in mouse oocytes through two opposite pathways
- Phosphorylation and N-terminal region of yeast ribosomal protein P1 mediate its degradation, which is prevented by protein P2 FREE
  Gretel Nusspaumer, Miguel Remacha and Juan P.G. Ballesta
  The EMBO Journal (2000), 19, - 6075 - 6084, doi:10.1093/emboj/19.22.6075
  - Abstract - Phosphorylation and N-terminal region of yeast ribosomal protein P1 mediate its degradation, which is prevented by protein P2
  - Full text
  - PDF (446 KB) - Phosphorylation and N-terminal region of yeast ribosomal protein P1 mediate its degradation, which is prevented by protein P2
- Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4 FREE
  Marc Blondel, Jean-Marc Galan, Yong Chi, Céline Lafourcade, Céline Longaretti, Raymond J. Deshaies and Matthias Peter
  The EMBO Journal (2000), 19, - 6085 - 6097, doi:10.1093/emboj/19.22.6085
  - Abstract - Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4
  - Full text
  - PDF (1,089 KB) - Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4
  - Supplementary information
- The fission yeast -tubulin complex is required in G₁ phase and is a component of the spindle assembly checkpoint FREE
  Leah Vardy and Takashi Toda
  The EMBO Journal (2000), 19, - 6098 - 6111, doi:10.1093/emboj/19.22.6098
  - Abstract - The fission yeast [gamma]-tubulin complex is required in G: 1: phase and is a component of the spindle assembly checkpoint
  - Full text
  - PDF (1,242 KB) - The fission yeast [gamma]-tubulin complex is required in G: 1: phase and is a component of the spindle assembly checkpoint
- c-Myb regulates the proliferation of immature thymocytes following -selection FREE
  Richard Pearson and Kathleen Weston
  The EMBO Journal (2000), 19, - 6112 - 6120, doi:10.1093/emboj/19.22.6112
  - Abstract - c-Myb regulates the proliferation of immature thymocytes following [beta]-selection
  - Full text
  - PDF (379 KB) - c-Myb regulates the proliferation of immature thymocytes following [beta]-selection
- Pontin52 and Reptin52 function as antagonistic regulators of -catenin signalling activity FREE
  Andreas Bauer, Sophie Chauvet, Otmar Huber, Fabrice Usseglio, Ute Rothbächer, Denise Aragnol, Rolf Kemler and Jacques Pradel
  The EMBO Journal (2000), 19, - 6121 - 6130, doi:10.1093/emboj/19.22.6121
  - Abstract - Pontin52 and Reptin52 function as antagonistic regulators of [beta]-catenin signalling activity
  - Full text
  - PDF (804 KB) - Pontin52 and Reptin52 function as antagonistic regulators of [beta]-catenin signalling activity
- Chromosomal localization links the SIN3–RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression FREE
  Lori A. Pile and David A. Wassarman
  The EMBO Journal (2000), 19, - 6131 - 6140, doi:10.1093/emboj/19.22.6131
  - Abstract - Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression
  - Full text
  - PDF (1,124 KB) - Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression
- The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p FREE
  David J. Owen, Prisca Ornaghi, Ji-Chun Yang, Nicholas Lowe, Philip R. Evans, Paola Ballario, David Neuhaus, Patrizia Filetici and Andrew A. Travers
  The EMBO Journal (2000), 19, - 6141 - 6149, doi:10.1093/emboj/19.22.6141
  - Abstract - The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
  - Full text
  - PDF (647 KB) - The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
- Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis FREE
  Hailing Jin, Eleonora Cominelli, Paul Bailey, Adrian Parr, Frank Mehrtens, Jonathon Jones, Chiara Tonelli, Bernd Weisshaar and Cathie Martin
  The EMBO Journal (2000), 19, - 6150 - 6161, doi:10.1093/emboj/19.22.6150
  - Abstract - Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in : Arabidopsis
  - Full text
  - PDF (820 KB) - Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in : Arabidopsis
- Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker FREE
  Rajeev Sivasankaran, M. Alessandra Vigano, Bruno Müller, Markus Affolter and Konrad Basler
  The EMBO Journal (2000), 19, - 6162 - 6172, doi:10.1093/emboj/19.22.6162
  - Abstract - Direct transcriptional control of the Dpp target : omb: by the DNA binding protein Brinker
  - Full text
  - PDF (1,039 KB) - Direct transcriptional control of the Dpp target : omb: by the DNA binding protein Brinker
- Vav-2 controls NFAT-dependent transcription inB- but not T-lymphocytes FREE
  Gina M. Doody, Daniel D. Billadeau, Elizabeth Clayton, Amanda Hutchings, Robert Berland, Simon McAdam, Paul J. Leibson and Martin Turner
  The EMBO Journal (2000), 19, - 6173 - 6184, doi:10.1093/emboj/19.22.6173
  - Abstract - Vav-2 controls NFAT-dependent transcription inB- but not T-lymphocytes
  - Full text
  - PDF (643 KB) - Vav-2 controls NFAT-dependent transcription inB- but not T-lymphocytes
- Regulation of p53 activity in nuclear bodies by a specific PML isoform FREE
  Valentina Fogal, Monica Gostissa, Peter Sandy, Paola Zacchi, Thomas Sternsdorf, Kirsten Jensen, Pier Paolo Pandolfi, Hans Will, Claudio Schneider and Giannino Del Sal
  The EMBO Journal (2000), 19, - 6185 - 6195, doi:10.1093/emboj/19.22.6185
  - Abstract - Regulation of p53 activity in nuclear bodies by a specific PML isoform
  - Full text
  - PDF (1,062 KB) - Regulation of p53 activity in nuclear bodies by a specific PML isoform
- Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor FREE
  Kevin M. McBride, Christine McDonald and Nancy C. Reich
  The EMBO Journal (2000), 19, - 6196 - 6206, doi:10.1093/emboj/19.22.6196
  - Abstract - Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor
  - Full text
  - PDF (797 KB) - Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor
- Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction FREE
  Andreas Hofmann, Alexander Zdanov, Pascal Genschik, Sergei Ruvinov, Witold Filipowicz and Alexander Wlodawer
  The EMBO Journal (2000), 19, - 6207 - 6217, doi:10.1093/emboj/19.22.6207
  - Abstract - Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction
  - Full text
  - PDF (838 KB) - Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction
- Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3'-processing apparatus FREE
  Alessandro Fatica, Mariangela Morlando and Irene Bozzoni
  The EMBO Journal (2000), 19, - 6218 - 6229, doi:10.1093/emboj/19.22.6218
  - Abstract - Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3[prime]-processing apparatus
  - Full text
  - PDF (759 KB) - Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3[prime]-processing apparatus
- Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting FREE
  Stefan Aigner, Joachim Lingner, Karen J. Goodrich, Cheryl A. Grosshans, Andrej Shevchenko, Matthias Mann and Thomas R. Cech
  The EMBO Journal (2000), 19, - 6230 - 6239, doi:10.1093/emboj/19.22.6230
  - Abstract - Euplotes: telomerase contains an La motif protein produced by apparent translational frameshifting
  - Full text
  - PDF (620 KB) - Euplotes: telomerase contains an La motif protein produced by apparent translational frameshifting
  - Supplementary information
- The eclipse period of Escherichia coli FREE
  Ulrik von Freiesleben, Martin A. Krekling, Flemming G. Hansen and Anders Løbner-Olesen
  The EMBO Journal (2000), 19, - 6240 - 6248, doi:10.1093/emboj/19.22.6240
  - Abstract - The eclipse period of : Escherichia coli
  - Full text
  - PDF (223 KB) - The eclipse period of : Escherichia coli
- A case for sliding SeqA tracts at anchored replication forks during Escherichia coli chromosome replication and segregation FREE
  Therese Brendler, Jim Sawitzke, Kirill Sergueev and Stuart Austin
  The EMBO Journal (2000), 19, - 6249 - 6258, doi:10.1093/emboj/19.22.6249
  - Abstract - A case for sliding SeqA tracts at anchored replication forks during : Escherichia coli: chromosome replication and segregation
  - Full text
  - PDF (438 KB) - A case for sliding SeqA tracts at anchored replication forks during : Escherichia coli: chromosome replication and segregation
- All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis FREE
  R. Napolitano, R. Janel-Bintz, J. Wagner and R. P. P. Fuchs
  The EMBO Journal (2000), 19, - 6259 - 6265, doi:10.1093/emboj/19.22.6259
  - Abstract - All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis
  - Full text
  - PDF (236 KB) - All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis
- The acidic pin of RuvA modulates Holliday junction binding and processing by the RuvABC resolvasome FREE
  Stuart M. Ingleston, Gary J. Sharples and Robert G. Lloyd
  The EMBO Journal (2000), 19, - 6266 - 6274, doi:10.1093/emboj/19.22.6266
  - Abstract - The acidic pin of RuvA modulates Holliday junction binding and processing by the RuvABC resolvasome
  - Full text
  - PDF (650 KB) - The acidic pin of RuvA modulates Holliday junction binding and processing by the RuvABC resolvasome
- The polymerase subunit of a dsRNA virus plays a central role in the regulation of viral RNA metabolism FREE
  Eugeny V. Makeyev and Dennis H. Bamford
  The EMBO Journal (2000), 19, - 6275 - 6284, doi:10.1093/emboj/19.22.6275
  - Abstract - The polymerase subunit of a dsRNA virus plays a central role in the regulation of viral RNA metabolism
  - Full text
  - PDF (678 KB) - The polymerase subunit of a dsRNA virus plays a central role in the regulation of viral RNA metabolism

Table of Contents

Volume 19, Number 22 15 November 2000

New EMBO Members Review

Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives FREE

Articles

Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis FREE

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining FREE

Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations FREE

Protein folding in the periplasm in the absence of primary oxidant DsbA: modulation of redox potential in periplasmic space via OmpL porin FREE

Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins FREE

Exocytosis requires asymmetry in the central layer of the SNARE complex FREE

Dual interaction of synaptotagmin with 2- and -adaptin facilitates clathrin-coated pit nucleation FREE

Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin–catenins complex FREE

Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei: the time bomb theory of ookinete invasion of mosquitoes FREE

Signal transduction to the Azotobacter vinelandii NIFL–NIFA regulatory system is influenced directly by interaction with 2-oxoglutarate and the PII regulatory protein FREE

Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells FREE

Mos activates MAP kinase in mouse oocytes through two opposite pathways FREE

Phosphorylation and N-terminal region of yeast ribosomal protein P1 mediate its degradation, which is prevented by protein P2 FREE

Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4 FREE

The fission yeast -tubulin complex is required in G1 phase and is a component of the spindle assembly checkpoint FREE

c-Myb regulates the proliferation of immature thymocytes following -selection FREE

Pontin52 and Reptin52 function as antagonistic regulators of -catenin signalling activity FREE

Chromosomal localization links the SIN3–RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression FREE

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p FREE

Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis FREE

Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker FREE

Vav-2 controls NFAT-dependent transcription inB- but not T-lymphocytes FREE

Regulation of p53 activity in nuclear bodies by a specific PML isoform FREE

Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor FREE

Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction FREE

Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3'-processing apparatus FREE

Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting FREE

The eclipse period of Escherichia coli FREE

A case for sliding SeqA tracts at anchored replication forks during Escherichia coli chromosome replication and segregation FREE

All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis FREE

The acidic pin of RuvA modulates Holliday junction binding and processing by the RuvABC resolvasome FREE

The polymerase subunit of a dsRNA virus plays a central role in the regulation of viral RNA metabolism FREE

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Volume 19, Number 22
15 November 2000

The fission yeast -tubulin complex is required in G₁ phase and is a component of the spindle assembly checkpoint FREE