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The EMBO Journal (2000) 19, 3428–3435, doi:10.1093/emboj/19.13.3428 Figure 6 Possible association of BLM in decreasing DNA double strand breaks during DNA replication Wensheng Wang, Masayuki Seki, Yoshiyasu Narita, Eiichiro Sonoda, Shunichi Takeda, Kouichi Yamada, Takashi Masuko, Toshiaki Katada and Takemi Enomoto

Figure 6 Southern blot analysis of drug-resistant clones. (A) Schematic representation of the wild-type allele and the targeted allele. The dotted line corresponds to the targeting construct. (B) The DNA samples were digested with BamHI and hybridized to the probe shown in (A). A typical Southern blot is shown. Arrowheads indicate the position of the fragment representing the targeted allele. +, targeted integration.

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