Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

The EMBO Journal (2000) 19, 2465–2474, doi:10.1093/emboj/19.11.2465

Table 2

Marella F.T.R. de Bruijn, Nancy A. Speck, Marian C.E. Peeters and Elaine Dzierzak

Table 2: Spatial distribution of HSCs within the E12 UGR

Tissue	No. of mice repopulated/total transplanted^a
Gonads	1/10
Mesonephroi	4/11
Metanephroi	1/2^b
UGR^c	3/7
Aorta^d	9/11
AGM^c	5/6

^aTransplanted mice received 1–2 e.e. of subdissected tissue. Only mice with 10% donor repopulation in the peripheral blood at 4–5 months after transfer were included as positive. Data are from a total of two independent experiments. ^bFive embryo equivalents transplanted per mouse. ^cNeither UGR nor AGM include metanephroi. ^dAorta region: includes surrounding mesenchyme.



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