Table of Contents

Volume 18, Number 7
01 April 1999

pp 1723-2018

• EMBO Members Review

  Top of page

  • Molecular tinkering of G protein-coupled receptors: an evolutionary success FREE

    Joël Bockaert and Jean Philippe Pin

    The EMBO Journal (1999), 18, - 1723 - 1729, doi:10.1093/emboj/18.7.1723

    • Abstract - Molecular tinkering of G protein-coupled receptors: an evolutionary success
    • Full text
    • PDF (220 KB) - Molecular tinkering of G protein-coupled receptors: an evolutionary success

• Articles

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  • Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity FREE

    Natalia Levina, Sabine Tötemeyer, Neil R. Stokes, Petra Louis, Michael A. Jones and Ian R. Booth

    The EMBO Journal (1999), 18, - 1730 - 1737, doi:10.1093/emboj/18.7.1730

    • Abstract - Protection of : Escherichia coli: cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity
    • Full text
    • PDF (305 KB) - Protection of : Escherichia coli: cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity

  • A new crystal structure, Ca²⁺ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation FREE

    Olivier Pertz, Damir Bozic, Alexander W. Koch, Charlotte Fauser, Andrea Brancaccio and Jürgen Engel

    The EMBO Journal (1999), 18, - 1738 - 1747, doi:10.1093/emboj/18.7.1738

    • Abstract - A new crystal structure, Ca: 2+: dependence and mutational analysis reveal molecular details of E-cadherin homoassociation
    • Full text
    • PDF (566 KB) - A new crystal structure, Ca: 2+: dependence and mutational analysis reveal molecular details of E-cadherin homoassociation

  • Tyrosine phosphorylation of p62^Dok induced by cell adhesion and insulin: possible role in cell migration FREE

    Tetsuya Noguchi, Takashi Matozaki, Kenjiro Inagaki, Masahiro Tsuda, Kaoru Fukunaga, Yukari Kitamura, Tadahiro Kitamura, Kozui Shii, Yuji Yamanashi and Masato Kasuga

    The EMBO Journal (1999), 18, - 1748 - 1760, doi:10.1093/emboj/18.7.1748

    • Abstract - Tyrosine phosphorylation of p62: Dok: induced by cell adhesion and insulin: possible role in cell migration
    • Full text
    • PDF (357 KB) - Tyrosine phosphorylation of p62: Dok: induced by cell adhesion and insulin: possible role in cell migration

  • Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein–lipid complexes FREE

    Maria Dolores Ledesma, Britta Brügger, Carsten Bünning, Felix T. Wieland and Carlos G. Dotti

    The EMBO Journal (1999), 18, - 1761 - 1771, doi:10.1093/emboj/18.7.1761

    • Abstract - Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes
    • Full text
    • PDF (305 KB) - Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes

  • Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome FREE

    Marie-Hélène Cuif, Franziska Possmayer, Hilke Zander, Nicole Bordes, Florence Jollivet, Anne Couedel-Courteille, Isabelle Janoueix-Lerosey, Gordon Langsley, Michel Bornens and Bruno Goud

    The EMBO Journal (1999), 18, - 1772 - 1782, doi:10.1093/emboj/18.7.1772

    • Abstract - Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome
    • Full text
    • PDF (655 KB) - Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome

  • CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans FREE

    S. Felkai, J.J. Ewbank, J. Lemieux, J.-C Labbé, G.G. Brown and S Hekimi

    The EMBO Journal (1999), 18, - 1783 - 1792, doi:10.1093/emboj/18.7.1783

    • Abstract - CLK-1 controls respiration, behavior and aging in the nematode : Caenorhabditis elegans
    • Full text
    • PDF (282 KB) - CLK-1 controls respiration, behavior and aging in the nematode : Caenorhabditis elegans

  • Assembly of thick filaments and myofibrils occurs in the absence of the myosin head FREE

    Richard M. Cripps, Jennifer A. Suggs and Sanford I. Bernstein

    The EMBO Journal (1999), 18, - 1793 - 1804, doi:10.1093/emboj/18.7.1793

    • Abstract - Assembly of thick filaments and myofibrils occurs in the absence of the myosin head
    • Full text
    • PDF (632 KB) - Assembly of thick filaments and myofibrils occurs in the absence of the myosin head

  • Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 FREE

    Tamar Unger, Tamar Juven-Gershon, Eli Moallem, Michael Berger, Ronit Vogt Sionov, Guillermina Lozano, Moshe Oren and Ygal Haupt

    The EMBO Journal (1999), 18, - 1805 - 1814, doi:10.1093/emboj/18.7.1805

    • Abstract - Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
    • Full text
    • PDF (267 KB) - Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

  • DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization FREE

    Sheau-Yann Shieh, Yoichi Taya and Carol Prives

    The EMBO Journal (1999), 18, - 1815 - 1823, doi:10.1093/emboj/18.7.1815

    • Abstract - DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
    • Full text
    • PDF (252 KB) - DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

  • Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas FREE

    Janos Peli, Michael Schröter, Claude Rudaz, Michael Hahne, Christine Meyer, Ernst Reichmann and Jürg Tschopp

    The EMBO Journal (1999), 18, - 1824 - 1831, doi:10.1093/emboj/18.7.1824

    • Abstract - Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas
    • Full text
    • PDF (273 KB) - Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas

  • Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-1 and Ras activation FREE

    Brandi L. Williams, Brenda J. Irvin, Shari L. Sutor, Claudia C. S. Chini, Elaine Yacyshyn, Juliane Bubeck Wardenburg, Mark Dalton, Andrew C. Chan and Robert T. Abraham

    The EMBO Journal (1999), 18, - 1832 - 1844, doi:10.1093/emboj/18.7.1832

    • Abstract - Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-[gamma]1 and Ras activation
    • Full text
    • PDF (430 KB) - Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-[gamma]1 and Ras activation

  • Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice FREE

    Hong-Tao Lu, Derek D. Yang, Mark Wysk, Evelina Gatti, Ira Mellman, Roger J. Davis and Richard A. Flavell

    The EMBO Journal (1999), 18, - 1845 - 1857, doi:10.1093/emboj/18.7.1845

    • Abstract - Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (: Mkk3: )-deficient mice
    • Full text
    • PDF (455 KB) - Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (: Mkk3: )-deficient mice

  • Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450 FREE

    Oliwia Witczak, Bjørn S. Skålhegg, Guy Keryer, Michel Bornens, Kjetil Taskén, Tore Jahnsen and Sigurd Ørstavik

    The EMBO Journal (1999), 18, - 1858 - 1868, doi:10.1093/emboj/18.7.1858

    • Abstract - Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450
    • Full text
    • PDF (515 KB) - Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450

  • Speedy: a novel cell cycle regulator of the G₂/M transition FREE

    Jean-Luc Lenormand, Ryan W. Dellinger, Karen E. Knudsen, Suresh Subramani and Daniel J. Donoghue

    The EMBO Journal (1999), 18, - 1869 - 1877, doi:10.1093/emboj/18.7.1869

    • Abstract - Speedy: a novel cell cycle regulator of the G: 2: /M transition
    • Full text
    • PDF (330 KB) - Speedy: a novel cell cycle regulator of the G: 2: /M transition

  • Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex FREE

    Laurent Le Cam, Jolanta Polanowska, Eric Fabbrizio, Magali Olivier, Alexandre Philips, Eleonor Ng Eaton, Marie Classon, Yan Geng and Claude Sardet

    The EMBO Journal (1999), 18, - 1878 - 1890, doi:10.1093/emboj/18.7.1878

    • Abstract - Timing of : cyclin E: gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex
    • Full text
    • PDF (420 KB) - Timing of : cyclin E: gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex

  • Phosphorylation by G₁-specific cdk–cyclin complexes activates the nucleolar transcription factor UBF FREE

    Renate Voit, Manuela Hoffmann and Ingrid Grummt

    The EMBO Journal (1999), 18, - 1891 - 1899, doi:10.1093/emboj/18.7.1891

    • Abstract - Phosphorylation by G: 1: -specific cdk-cyclin complexes activates the nucleolar transcription factor UBF
    • Full text
    • PDF (228 KB) - Phosphorylation by G: 1: -specific cdk-cyclin complexes activates the nucleolar transcription factor UBF

  • Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone FREE

    Roy E. Weiss, Jianming Xu, Guang Ning, Joachim Pohlenz, Bert W. O'Malley and Samuel Refetoff

    The EMBO Journal (1999), 18, - 1900 - 1904, doi:10.1093/emboj/18.7.1900

    • Abstract - Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone
    • Full text
    • PDF (157 KB) - Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone

  • Molecular mechanisms of transcription activation by HLF and HIF1 in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 FREE

    Masatsugu Ema, Kiichi Hirota, Junsei Mimura, Hisaku Abe, Junji Yodoi, Kazuhiro Sogawa, Lorenz Poellinger and Yoshiaki Fujii-Kuriyama

    The EMBO Journal (1999), 18, - 1905 - 1914, doi:10.1093/emboj/18.7.1905

    • Abstract - Molecular mechanisms of transcription activation by HLF and HIF1[alpha] in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300
    • Full text
    • PDF (544 KB) - Molecular mechanisms of transcription activation by HLF and HIF1[alpha] in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

  • MyoD stimulates Delta-1 transcription and triggers Notch signaling in the Xenopus gastrula FREE

    Timo Wittenberger, Oliver C. Steinbach, Agathe Authaler, Raphael Kopan and Ralph A.W. Rupp

    The EMBO Journal (1999), 18, - 1915 - 1922, doi:10.1093/emboj/18.7.1915

    • Abstract - MyoD stimulates Delta-1 transcription and triggers Notch signaling in the : Xenopus: gastrula
    • Full text
    • PDF (302 KB) - MyoD stimulates Delta-1 transcription and triggers Notch signaling in the : Xenopus: gastrula

  • Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31 FREE

    Louise Aagaard, Götz Laible, Philipp Selenko, Manfred Schmid, Rainer Dorn, Gunnar Schotta, Steffi Kuhfittig, Andrea Wolf, Angelika Lebersorger, Prim B. Singh, Gunter Reuter and Thomas Jenuwein

    The EMBO Journal (1999), 18, - 1923 - 1938, doi:10.1093/emboj/18.7.1923

    • Abstract - Functional mammalian homologues of the : Drosophila: PEV-modifier : Su(var)3-9: encode centromere-associated proteins which complex with the heterochromatin component M31
    • Full text
    • PDF (659 KB) - Functional mammalian homologues of the : Drosophila: PEV-modifier : Su(var)3-9: encode centromere-associated proteins which complex with the heterochromatin component M31

  • Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization FREE

    Marco Blanchette and Benoit Chabot

    The EMBO Journal (1999), 18, - 1939 - 1952, doi:10.1093/emboj/18.7.1939

    • Abstract - Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization
    • Full text
    • PDF (449 KB) - Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization

  • Sequence interval within the PEST motif of Bicoid is important for translational repression of caudal mRNA in the anterior region of the Drosophila embryo FREE

    Dierk Niessing, Nathalie Dostatni, Herbert Jäckle and Rolando Rivera-Pomar

    The EMBO Journal (1999), 18, - 1966 - 1973, doi:10.1093/emboj/18.7.1966

    • Abstract - Sequence interval within the PEST motif of Bicoid is important for translational repression of : caudal: mRNA in the anterior region of the : Drosophila: embryo
    • Full text
    • PDF (230 KB) - Sequence interval within the PEST motif of Bicoid is important for translational repression of : caudal: mRNA in the anterior region of the : Drosophila: embryo

  • Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism FREE

    Simon S. Eaglestone, Brian S. Cox and Mick F. Tuite

    The EMBO Journal (1999), 18, - 1974 - 1981, doi:10.1093/emboj/18.7.1974

    • Abstract - Translation termination efficiency can be regulated in : Saccharomyces cerevisiae: by environmental stress through a prion-mediated mechanism
    • Full text
    • PDF (266 KB) - Translation termination efficiency can be regulated in : Saccharomyces cerevisiae: by environmental stress through a prion-mediated mechanism

  • Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain FREE

    Sara Nakielny, Sarah Shaikh, Brian Burke and Gideon Dreyfuss

    The EMBO Journal (1999), 18, - 1982 - 1995, doi:10.1093/emboj/18.7.1982

    • Abstract - Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain
    • Full text
    • PDF (420 KB) - Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain

  • The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein FREE

    Manuel Rodríguez-Concepción, Shaul Yalovsky, Moriyah Zik, Hillel Fromm and Wilhelm Gruissem

    The EMBO Journal (1999), 18, - 1996 - 2007, doi:10.1093/emboj/18.7.1996

    • Abstract - The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein
    • Full text
    • PDF (459 KB) - The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein

  • DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity FREE

    Mauro Modesti, Joanne E. Hesse and Martin Gellert

    The EMBO Journal (1999), 18, - 2008 - 2018, doi:10.1093/emboj/18.7.2008

    • Abstract - DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity
    • Full text
    • PDF (300 KB) - DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

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