New EMBO Members Review
- The EMBO Journal (1999) 18, 6873 - 6879
- doi:10.1093/emboj/18.24.6873
Planar polarity in the Drosophila eye: a multifaceted view of signaling specificity and cross-talk
Marek Mlodzik1
- EMBL, Developmental Biology Programme, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Correspondence to:
Marek Mlodzik, E-mail: mlodzik@embl-heidelberg.de
Received 13 August 1999; Accepted 22 October 1999; Revised 21 October 1999
Abstract
Functional tissues not only polarize their epithelia in the apical–basolateral axis, but also often display a polarity within the plane of the epithelium. In Drosophila, all adult structures are derived from epithelia called imaginal discs and display planar polarization; the eye and the wing are particularly well suited for analysis. Studies of their polarization have identified several conserved genes that regulate both nuclear signaling and cytoskeletal architecture. In particular, the Frizzled (Fz) receptor has been identified as a key component of polarity establishment in all tissues. The Fz signaling pathway and associated events are beginning to be unraveled, shedding light on a novel Wnt/Fz signaling cascade.
Keywords:
- cytoskeletal organization,
- Dishevelled,
- Frizzled,
- nuclear signaling,
- planar polarity
