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The EMBO Journal (1999) 18, 5061–5072, doi:10.1093/emboj/18.18.5061

Table 1
The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300
Daksha Patel, Shih-Min Huang, Laurel A. Baglia and Dennis J. McCance
Table 1: Relative binding of wild-type E6.16, E6.6 and E6.16 mutations to p300 N-terminal, C/H3 and CT3 domains using a PhosphorImager
E6 constructs p300 constructs
Amino acids 1–595 C/H3 domain C-terminus (CT3)
% input bound Relative binding % input bound Relative binding % input bound Relative binding
E6.16 11 1 5 1 10 1
E6.6 6 0.5 0.1 0.02 0.1 0.01
E6.168S9A10T 2 0.2 0.3 0.06 NTa NT
E6.1645Y47Y49H 13 1.3 1.1 0.22 0.1 0.01
E6.16C66G/C136G 0.2 0.02 0.3 0.06 NT NT
E6.16Delta106–110 6 0.5 0.6 0.12 NT NT
E6.16Delta123–127 3 0.3 0.4 0.08 0.1 0.01
E6.16Delta128–132 8 0.7 2.2 0.44 0.1 0.01
E6.16Delta133–137 6 0.6 0.7 0.14 NT NT

aNT, not tested
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