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| The EMBO Journal
(1999) 18, 4657–4668, doi:10.1093/emboj/18.17.4657 |
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| Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis |
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| Shigetoshi Sano1, Satoshi Itami1, Kiyoshi Takeda2, Masahito Tarutani1, Yuji Yamaguchi1, Hiroyuki Miura1, Kunihiko Yoshikawa1, Shizuo Akira2 and Junji Takeda3 |
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1 Department of Dermatology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan 2 Department of Biochemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan 3 Department of Environmental Medicine, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan To whom correspondence should be addressed Junji Takeda, takeda@mr-envi.med.osaka-u.ac.jp Received 19 May 1999; Revised 14 July 1999; Accepted 14 July 1999. |
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| Abstract |
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| To elucidate the biological role of Stat3 in the skin, conditional gene targeting using the Cre-loxP system was performed as germline Stat3 ablation leads to embryonic lethality. K5-Cre;Stat3flox/- transgenic mice, whose epidermal and follicular keratinocytes lack functional Stat3, were viable and the development of epidermis and hair follicles appeared normal. However, hair cycle and wound healing processes were severely compromised. Furthermore, mutant mice expressed sparse hair and developed spontaneously occurring ulcers with age. Growth factor-dependent in vitro migration of Stat3-disrupted keratinocytes was impaired despite normal proliferative responses. We therefore conclude that Stat3 plays a crucial role in transducing a signal required for migration but not for proliferation of keratinocytes, and that Stat3 is essential for skin remodeling, including hair cycle and wound healing. |
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| Keywords: conditional gene targeting, hair cycle, skin remodeling, Stat3, wound healing |
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