Table of Contents

Volume 17, Number 12
15 June 1998

pp 3219-3502

• Articles

  Top of page

  • Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding FREE

    Maria A. Schumacher, Darrick Carter, Daniel M. Scott, David S. Roos, Buddy Ullman and Richard G. Brennan

    The EMBO Journal (1998), 17, - 3219 - 3232, doi:10.1093/emboj/17.12.3219

    • Abstract - Crystal structures of : Toxoplasma gondii: uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding
    • Full text
    • PDF (948 KB) - Crystal structures of : Toxoplasma gondii: uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding

  • Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry FREE

    Xiaojiang S. Chen, Thilo Stehle and Stephen C. Harrison

    The EMBO Journal (1998), 17, - 3233 - 3240, doi:10.1093/emboj/17.12.3233

    • Abstract - Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry
    • Full text
    • PDF (645 KB) - Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry

  • UBPY: a growth-regulated human ubiquitin isopeptidase FREE

    Silvio Naviglio, Cristian Matteucci, Brona Matoskova, Takahiro Nagase, Nobuo Nomura, Pier Paolo Di Fiore and Giulio Francesco Draetta

    The EMBO Journal (1998), 17, - 3241 - 3250, doi:10.1093/emboj/17.12.3241

    • Abstract - UBPY: a growth-regulated human ubiquitin isopeptidase
    • Full text
    • PDF (509 KB) - UBPY: a growth-regulated human ubiquitin isopeptidase

  • Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein FREE

    Thomas U. Mayer, Thorsten Braun and Stefan Jentsch

    The EMBO Journal (1998), 17, - 3251 - 3257, doi:10.1093/emboj/17.12.3251

    • Abstract - Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein
    • Full text
    • PDF (218 KB) - Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

  • Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae FREE

    Francis A. Barr, Nobuhiro Nakamura and Graham Warren

    The EMBO Journal (1998), 17, - 3258 - 3268, doi:10.1093/emboj/17.12.3258

    • Abstract - Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae
    • Full text
    • PDF (737 KB) - Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae

  • Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion FREE

    Christian Ungermann and William Wickner

    The EMBO Journal (1998), 17, - 3269 - 3276, doi:10.1093/emboj/17.12.3269

    • Abstract - Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion
    • Full text
    • PDF (408 KB) - Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion

  • Chromogranin B (secretogranin I), a neuroendocrine-regulated secretory protein, is sorted to exocrine secretory granules in transgenic mice FREE

    Shoichi Natori, Angus King, Andrea Hellwig, Ursula Wei, Haruo Iguchi, Benio Tsuchiya, Toru Kameya, Ryoichi Takayanagi, Hajime Nawata and Wieland B. Huttner

    The EMBO Journal (1998), 17, - 3277 - 3289, doi:10.1093/emboj/17.12.3277

    • Abstract - Chromogranin B (secretogranin I), a neuroendocrine-regulated secretory protein, is sorted to exocrine secretory granules in transgenic mice
    • Full text
    • PDF (949 KB) - Chromogranin B (secretogranin I), a neuroendocrine-regulated secretory protein, is sorted to exocrine secretory granules in transgenic mice

  • Molecular determinants of K_ATP channel inhibition by ATP FREE

    Stephen J. Tucker, Fiona M. Gribble, Peter Proks, Stefan Trapp, Timothy J. Ryder, Trude Haug, Frank Reimann and Frances M. Ashcroft

    The EMBO Journal (1998), 17, - 3290 - 3296, doi:10.1093/emboj/17.12.3290

    • Abstract - Molecular determinants of K: ATP: channel inhibition by ATP
    • Full text
    • PDF (409 KB) - Molecular determinants of K: ATP: channel inhibition by ATP

  • A neuronal two P domain K⁺ channel stimulated by arachidonic acid and polyunsaturated fatty acids FREE

    Michel Fink, Florian Lesage, Fabrice Duprat, Catherine Heurteaux, Roberto Reyes, Michel Fosset and Michel Lazdunski

    The EMBO Journal (1998), 17, - 3297 - 3308, doi:10.1093/emboj/17.12.3297

    • Abstract - A neuronal two P domain K: +: channel stimulated by arachidonic acid and polyunsaturated fatty acids
    • Full text
    • PDF (1,214 KB) - A neuronal two P domain K: +: channel stimulated by arachidonic acid and polyunsaturated fatty acids

  • Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2 FREE

    Hiroshi Takeshima, Shinji Komazaki, Kenzo Hirose, Miyuki Nishi, Tetsuo Noda and Masamitsu Iino

    The EMBO Journal (1998), 17, - 3309 - 3316, doi:10.1093/emboj/17.12.3309

    • Abstract - Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2
    • Full text
    • PDF (713 KB) - Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2

  • Antagonism in the human mineralocorticoid receptor FREE

    Jérôme Fagart, Jean-Marie Wurtz, Anny Souque, Chantal Hellal-Levy, Dino Moras and Marie-Edith Rafestin-Oblin

    The EMBO Journal (1998), 17, - 3317 - 3325, doi:10.1093/emboj/17.12.3317

    • Abstract - Antagonism in the human mineralocorticoid receptor
    • Full text
    • PDF (660 KB) - Antagonism in the human mineralocorticoid receptor

  • Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae FREE

    Sonia Colombo, Pingsheng Ma, Liesbet Cauwenberg, Joris Winderickx, Marion Crauwels, Aloys Teunissen, David Nauwelaers, Johannes H. de Winde, Marie-Françoise Gorwa, Didier Colavizza and Johan M. Thevelein

    The EMBO Journal (1998), 17, - 3326 - 3341, doi:10.1093/emboj/17.12.3326

    • Abstract - Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast : Saccharomyces cerevisiae
    • Full text
    • PDF (742 KB) - Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast : Saccharomyces cerevisiae

  • How p53 binds DNA as a tetramer FREE

    Kevin G. McLure and Patrick W.K. Lee

    The EMBO Journal (1998), 17, - 3342 - 3350, doi:10.1093/emboj/17.12.3342

    • Abstract - How p53 binds DNA as a tetramer
    • Full text
    • PDF (385 KB) - How p53 binds DNA as a tetramer

  • The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus FREE

    James E. Strong, Matthew C. Coffey, Damu Tang, Pauline Sabinin and Patrick W.K. Lee

    The EMBO Journal (1998), 17, - 3351 - 3362, doi:10.1093/emboj/17.12.3351

    • Abstract - The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus
    • Full text
    • PDF (518 KB) - The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus

  • Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation FREE

    Katrin Engel, Alexey Kotlyarov and Matthias Gaestel

    The EMBO Journal (1998), 17, - 3363 - 3371, doi:10.1093/emboj/17.12.3363

    • Abstract - Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
    • Full text
    • PDF (346 KB) - Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

  • PRAK, a novel protein kinase regulated by the p38 MAP kinase FREE

    Liguo New, Yong Jiang, Ming Zhao, Kang Liu, Wei Zhu, Laura J. Flood, Yutaka Kato, Graham C.N. Parry and Jiahuai Han

    The EMBO Journal (1998), 17, - 3372 - 3384, doi:10.1093/emboj/17.12.3372

    • Abstract - PRAK, a novel protein kinase regulated by the p38 MAP kinase
    • Full text
    • PDF (855 KB) - PRAK, a novel protein kinase regulated by the p38 MAP kinase

  • Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers FREE

    Anne E.G. Lenferink, Ronit Pinkas-Kramarski, Monique L.M. van de Poll, Marianne J.H. van Vugt, Leah N. Klapper, Eldad Tzahar, Hadassa Waterman, Michael Sela, Everardus J.J. van Zoelen and Yosef Yarden

    The EMBO Journal (1998), 17, - 3385 - 3397, doi:10.1093/emboj/17.12.3385

    • Abstract - Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers
    • Full text
    • PDF (543 KB) - Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

  • Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators FREE

    Ningwu Huang, Elmar vom Baur, Jean-Marie Garnier, Thierry Lerouge, Jean-Luc Vonesch, Yves Lutz, P. Chambon and Régine Losson

    The EMBO Journal (1998), 17, - 3398 - 3412, doi:10.1093/emboj/17.12.3398

    • Abstract - Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators
    • Full text
    • PDF (1,610 KB) - Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

  • Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3 FREE

    Harry V. Isaacs, Mary Elizabeth Pownall and Jonathan M.W. Slack

    The EMBO Journal (1998), 17, - 3413 - 3427, doi:10.1093/emboj/17.12.3413

    • Abstract - Regulation of Hox gene expression and posterior development by the : Xenopus: caudal homologue Xcad3
    • Full text
    • PDF (625 KB) - Regulation of Hox gene expression and posterior development by the : Xenopus: caudal homologue Xcad3

  • In vitro chromatin remodelling by chromatin accessibility complex (CHRAC) at the SV40 origin of DNA replication FREE

    Vassilios Alexiadis, Patrick D. Varga-Weisz, Edgar Bonte, Peter B. Becker and Claudia Gruss

    The EMBO Journal (1998), 17, - 3428 - 3438, doi:10.1093/emboj/17.12.3428

    • Abstract - In vitro: chromatin remodelling by chromatin accessibility complex (CHRAC) at the SV40 origin of DNA replication
    • Full text
    • PDF (506 KB) - In vitro: chromatin remodelling by chromatin accessibility complex (CHRAC) at the SV40 origin of DNA replication

  • Transcription activation at Class II CRP-dependent promoters: identification of determinants in the C-terminal domain of the RNA polymerase subunit FREE

    Nigel J. Savery, Georgina S. Lloyd, Mark Kainz, Tamas Gaal, Wilma Ross, Richard H. Ebright, Richard L. Gourse and Stephen J.W. Busby

    The EMBO Journal (1998), 17, - 3439 - 3447, doi:10.1093/emboj/17.12.3439

    • Abstract - Transcription activation at Class II CRP-dependent promoters: identification of determinants in the C-terminal domain of the RNA polymerase [alpha] subunit
    • Full text
    • PDF (624 KB) - Transcription activation at Class II CRP-dependent promoters: identification of determinants in the C-terminal domain of the RNA polymerase [alpha] subunit

  • Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs FREE

    Xinhao Cynthia Fan and Joan A. Steitz

    The EMBO Journal (1998), 17, - 3448 - 3460, doi:10.1093/emboj/17.12.3448

    • Abstract - Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the : in vivo: stability of ARE-containing mRNAs
    • Full text
    • PDF (468 KB) - Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the : in vivo: stability of ARE-containing mRNAs

  • RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein FREE

    Sheila S.-Y. Peng, Chyi-Ying A. Chen, Nianhua Xu and Ann-Bin Shyu

    The EMBO Journal (1998), 17, - 3461 - 3470, doi:10.1093/emboj/17.12.3461

    • Abstract - RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
    • Full text
    • PDF (387 KB) - RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein

  • The chaperonin of the archaeon Sulfolobus solfataricus is an RNA-binding protein that participates in ribosomal RNA processing FREE

    Davide Ruggero, Andrea Ciammaruconi and Paola Londei

    The EMBO Journal (1998), 17, - 3471 - 3477, doi:10.1093/emboj/17.12.3471

    • Abstract - The chaperonin of the archaeon : Sulfolobus solfataricus: is an RNA-binding protein that participates in ribosomal RNA processing
    • Full text
    • PDF (273 KB) - The chaperonin of the archaeon : Sulfolobus solfataricus: is an RNA-binding protein that participates in ribosomal RNA processing

  • EF-G-catalyzed translocation of anticodon stem–loop analogs of transfer RNA in the ribosome FREE

    Simpson Joseph and Harry F. Noller

    The EMBO Journal (1998), 17, - 3478 - 3483, doi:10.1093/emboj/17.12.3478

    • Abstract - EF-G-catalyzed translocation of anticodon stem-loop analogs of transfer RNA in the ribosome
    • Full text
    • PDF (238 KB) - EF-G-catalyzed translocation of anticodon stem-loop analogs of transfer RNA in the ribosome

  • Binary specification of nonsense codons by splicing and cytoplasmic translation FREE

    Rolf Thermann, Gabriele Neu-Yilik, Andrea Deters, Ute Frede, Kristina Wehr, Christian Hagemeier, Matthias W. Hentze and Andreas E. Kulozik

    The EMBO Journal (1998), 17, - 3484 - 3494, doi:10.1093/emboj/17.12.3484

    • Abstract - Binary specification of nonsense codons by splicing and cytoplasmic translation
    • Full text
    • PDF (540 KB) - Binary specification of nonsense codons by splicing and cytoplasmic translation

  • Influences of array size and homogeneity on minisatellite mutation FREE

    Jérôme Buard, Agnès Bourdet, Jane Yardley, Yuri Dubrova and Alec J. Jeffreys

    The EMBO Journal (1998), 17, - 3495 - 3502, doi:10.1093/emboj/17.12.3495

    • Abstract - Influences of array size and homogeneity on minisatellite mutation
    • Full text
    • PDF (480 KB) - Influences of array size and homogeneity on minisatellite mutation

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