Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

The EMBO Journal (1998) 17, 2830–2837, doi:10.1093/emboj/17.10.2830

Figure 3

Sphingosine kinase-mediated Ca²⁺ signalling by G-protein-coupled receptors

Dagmar Meyer zu Heringdorf, Holger Lass, Regina Alemany, Kai T. Laser, Eva Neumann, Chunyi Zhang, Martina Schmidt, Ursula Rauen, Karl H. Jakobs and Chris J. van Koppen

Figure 3
Influence of DHS and DMS on m2 and m3 mAChR-mediated PLC stimulation. Following 10 min treatment without (Control) and with 30

M DHS or 15

M DMS, formation of [³H]IP₃ (upper panels) and total [³H]inositol phosphates ([³H]IPs, lower panels) was determined in m2 and m3 mAChR-expressing HEK-293 cells in the absence (open bars) and presence (solid bars) of 100

M (m2 mAChR) or 0.3

M carbachol (m3 mAChR). Mean plusminus

SEM (n=4) from one experiment, representative of at least two similar experiments.


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