The EMBO Journal
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The EMBO Journal (1998) 17, 2830–2837, doi:10.1093/emboj/17.10.2830

Figure 2
Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors
Dagmar Meyer zu Heringdorf, Holger Lass, Regina Alemany, Kai T. Laser, Eva Neumann, Chunyi Zhang, Martina Schmidt, Ursula Rauen, Karl H. Jakobs and Chris J. van Koppen
Figure 2
Figure 2
 Concentration-dependent inhibition of m2 and m3 mAChR-induced [Ca2+]i increases by DHS and DMS. [Ca2+]i increases induced by 100 and 0.3 muM carbachol were determined in m2 (upper panel) and m3 (lower panel) mAChR-expressing HEK-293 cells, pretreated for 10 min with the indicated concentrations of DMS (square) or DHS (filled square). Mean plusminus SEM of three independent experiments, each carried out at least in duplicate.
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