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The EMBO Journal (1998) 17, 2767–2776, doi:10.1093/emboj/17.10.2767 |
| Figure 7 |
| Neural Wiskott–Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri |
| Toshihiko Suzuki, Hiroaki Miki, Tadaomi Takenawa and Chihiro Sasakawa |
-domain exposed on the bacterial surface binds vinculin and N-WASP. The vinculin could then interact with actin filaments and/or other signaling molecules such as VASP. The actin filaments recruited may be partially depolymerized by N-WASP and the uncapped barbed ends become exposed. At the uncapped barbed ends, actin polymerization would occur, possibly promoted by profilin. In this model, we are not sure whether or not the vinculin and N-WASP are recruited by VirG at the same time and by the same polypeptide.
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