Web focus: Quality Control

See also: protein quality control
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- The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90FREE
  Sebastian K Wandinger, Michael H Suhre, Harald Wegele and Johannes Buchner
  The EMBO Journal (2006), 25, - 367–376 | doi:10.1038/sj.emboj.7600930
  - Abstract - The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90
  - Full text
  - PDF (301 KB) - The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90
- The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A generation in vivoFREE
  Arames Crameri, Elisa Biondi, Katrin Kuehnle, Dieter Lütjohann, Karin M Thelen, Simona Perga, Carlos G Dotti, Roger M Nitsch, Maria Dolores Ledesma and M Hasan Mohajeri
  The EMBO Journal (2006), 25, - 432–443 | doi:10.1038/sj.emboj.7600938
  - Abstract - The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A[beta] generation : in vivo
  - Full text
  - PDF (225 KB) - The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A[beta] generation : in vivo
  - Supplementary information
- Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathwaysFREE
  Tommer Ravid, Stefan G Kreft and Mark Hochstrasser
  The EMBO Journal (2006), 25, - 533–543 | doi:10.1038/sj.emboj.7600946
  - Abstract - Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways
  - Full text
  - PDF (527 KB) - Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways
  - Supplementary information
- Molecular chaperones and the assembly of the prion Sup35p, an in vitro studyFREE
  Joanna Krzewska and Ronald Melki
  The EMBO Journal (2006), 25, - 822–833 | doi:10.1038/sj.emboj.7600985
  - Abstract - Molecular chaperones and the assembly of the prion Sup35p, an : in vitro: study
  - Full text
  - PDF (346 KB) - Molecular chaperones and the assembly of the prion Sup35p, an : in vitro: study
  - Supplementary information
- Adaptor protein controlled oligomerization activates the AAA+ protein ClpCFREE
  Janine Kirstein, Tilman Schlothauer, David A Dougan, Hauke Lilie, Gilbert Tischendorf, Axel Mogk, Bernd Bukau and Kürad Turgay
  The EMBO Journal (2006), 25, - 1481–1491 | doi:10.1038/sj.emboj.7601042
  - Abstract - Adaptor protein controlled oligomerization activates the AAA+ protein ClpC
  - Full text
  - PDF (422 KB) - Adaptor protein controlled oligomerization activates the AAA+ protein ClpC
  - Supplementary information
- An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesisFREE
  Annett Boeddrich, Sébastien Gaumer, Annette Haacke, Nikolay Tzvetkov, Mario Albrecht, Bernd O Evert, Eva C Müller, Rudi Lurz, Peter Breuer, Nancy Schugardt, Stephanie Plamann, Kexiang Xu, John M Warrick, Jaana Suopanki, Ullrich Wüllner, Ronald Frank, Ulrich F Hartl, Nancy M Bonini and Erich E Wanker
  The EMBO Journal (2006), 25, - 1547–1558 | doi:10.1038/sj.emboj.7601043
  - Abstract - An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
  - Full text
  - PDF (610 KB) - An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
  - Supplementary information
- Glycine–alanine repeats impair proper substrate unfolding by the proteasome FREE
  Martin A Hoyt, Judith Zich, Junko Takeuchi, Mingsheng Zhang, Cedric Govaerts and Philip Coffino
  The EMBO Journal (2006), 25, - 1720–1729 | doi:10.1038/sj.emboj.7601058
  - Abstract - Glycine-alanine repeats impair proper substrate unfolding by the proteasome
  - Full text
  - PDF (328 KB) - Glycine-alanine repeats impair proper substrate unfolding by the proteasome
  - Supplementary information
- The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitmentFREE
  Robert Gauss, Thomas Sommer and Ernst Jarosch
  The EMBO Journal (2006), 25, - 1827–1835 | doi:10.1038/sj.emboj.7601088
  - Abstract - The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
  - Full text
  - PDF (446 KB) - The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
  - Supplementary information
- An aging pathway controls the TrkA to p75^NTR receptor switch and amyloid -peptide generationFREE
  
  Claudio Costantini, Heidi Scrable and Luigi Puglielli
  The EMBO Journal (2006), 25, - 1997–2006 | doi:10.1038/sj.emboj.7601062
  - Abstract - An aging pathway controls the TrkA to p75: NTR: receptor switch and amyloid [beta]-peptide generation
  - Full text
  - PDF (447 KB) - An aging pathway controls the TrkA to p75: NTR: receptor switch and amyloid [beta]-peptide generation
  - Supplementary information
- Retrovirus infection strongly enhances scrapie infectivity release in cell cultureFREE
  Pascal Leblanc, Sandrine Alais, Isabel Porto-Carreiro, Sylvain Lehmann, Jacques Grassi, Graça Raposo and Jean Luc Darlix
  The EMBO Journal (2006), 25, - 2674–2685 | doi:10.1038/sj.emboj.7601162
  - Abstract - Retrovirus infection strongly enhances scrapie infectivity release in cell culture
  - Full text
  - PDF (585 KB) - Retrovirus infection strongly enhances scrapie infectivity release in cell culture
  - Supplementary information
- Regulation of mitochondrial morphology through proteolytic cleavage of OPA1 FREE
  Naotada Ishihara, Yuu Fujita, Toshihiko Oka and Katsuyoshi Mihara
  The EMBO Journal (2006), 25, - 2966–2977 | doi:10.1038/sj.emboj.7601184
  - Abstract - Regulation of mitochondrial morphology through proteolytic cleavage of OPA1
  - Full text
  - PDF (451 KB) - Regulation of mitochondrial morphology through proteolytic cleavage of OPA1
  - Supplementary information
- A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamicsFREE
  Ryo Yonashiro, Satoshi Ishido, Shinkou Kyo, Toshifumi Fukuda, Eiji Goto, Yohei Matsuki, Mari Ohmura-Hoshino, Kiyonao Sada, Hak Hotta, Hirohei Yamamura, Ryoko Inatome and Shigeru Yanagi
  The EMBO Journal (2006), 25, - 3618–3626 | doi:10.1038/sj.emboj.7601249
  - Abstract - A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics
  - Full text
  - PDF (445 KB) - A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics
  - Supplementary information
- Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neuronsFREE
  Mark J Barsoum, Hua Yuan, Akos A Gerencser, Géraldine Liot, Yulia Kushnareva, Simone Gräber, Imre Kovacs, Wilson D Lee, Jenna Waggoner, Jiankun Cui, Andrew D White, Blaise Bossy, Jean-Claude Martinou, Richard J Youle, Stuart A Lipton, Mark H Ellisman, Guy A Perkins and Ella Bossy-Wetzel
  The EMBO Journal (2006), 25, - 3900–3911 | doi:10.1038/sj.emboj.7601253
  - Abstract - Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
  - Full text
  - PDF (908 KB) - Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
  - Supplementary information
- Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagyFREE
  Susmita Kaushik, Ashish C Massey and Ana Maria Cuervo
  The EMBO Journal (2006), 25, - 3921–3933 | doi:10.1038/sj.emboj.7601283
  - Abstract - Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy
  - Full text
  - PDF (416 KB) - Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy
  - Supplementary information
- p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradationFREE
  Eric J Carlson, David Pitonzo and William R Skach
  The EMBO Journal (2006), 25, - 4557–4566 | doi:10.1038/sj.emboj.7601307
  - Abstract - p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation
  - Full text
  - PDF (251 KB) - p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation
  - Supplementary information
- ERp57 is essential for efficient folding of glycoproteins sharing common structural domainsFREE
  Catherine E Jessop, Seema Chakravarthi, Natalio Garbi, Günter J Hämmerling, Simon Lovell and Neil J Bulleid
  The EMBO Journal (2007), 26, - 28–40 | doi:10.1038/sj.emboj.7601505
  - Abstract - ERp57 is essential for efficient folding of glycoproteins sharing common structural domains
  - Full text
  - PDF (275 KB) - ERp57 is essential for efficient folding of glycoproteins sharing common structural domains
- Unfolded protein response in a Drosophila model for retinal degenerationFREE
  Hyung Don Ryoo, Pedro M Domingos, Min-Ji Kang and Hermann Steller
  The EMBO Journal (2007), 26, - 242–252 | doi:10.1038/sj.emboj.7601477
  - Abstract - Unfolded protein response in a : Drosophila: model for retinal degeneration
  - Full text
  - PDF (528 KB) - Unfolded protein response in a : Drosophila: model for retinal degeneration
  - Supplementary information
- m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondriaFREE
  Takashi Tatsuta, Steffen Augustin, Mark Nolden, Björn Friedrichs and Thomas Langer
  The EMBO Journal (2007), 26, - 325–335 | doi:10.1038/sj.emboj.7601514
  - Abstract - m: -AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria
  - Full text
  - PDF (468 KB) - m: -AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria
  - Supplementary information
- Lethal recessive myelin toxicity of prion protein lacking its central domainFREE
  Frank Baumann, Markus Tolnay, Christine Brabeck, Jens Pahnke, Ulrich Kloz, Hartmut H Niemann, Mathias Heikenwalder, Thomas Rülicke, Alexander Bürkle and Adriano Aguzzi
  The EMBO Journal (2007), 26, - 538–547 | doi:10.1038/sj.emboj.7601510
  - Abstract - Lethal recessive myelin toxicity of prion protein lacking its central domain
  - Full text
  - PDF (565 KB) - Lethal recessive myelin toxicity of prion protein lacking its central domain
  - Supplementary information
- Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105–125FREE
  Aimin Li, Heather M Christensen, Leanne R Stewart, Kevin A Roth, Roberto Chiesa and David A Harris
  The EMBO Journal (2007), 26, - 548–558 | doi:10.1038/sj.emboj.7601507
  - Abstract - Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125
  - Full text
  - PDF (476 KB) - Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125
- Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutantsFREE
  Cami K Bruns and Ron R Kopito
  The EMBO Journal (2007), 26, - 855–866 | doi:10.1038/sj.emboj.7601528
  - Abstract - Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutants
  - Full text
  - PDF (312 KB) - Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutants
- Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation FREE
  N Bhutani, P Venkatraman and A L Goldberg
  The EMBO Journal (2007), 26, - 1385–1396 | doi:10.1038/sj.emboj.7601592
  - Abstract - Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation
  - Full text
  - PDF (330 KB) - Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation
  - Supplementary information
- GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of A42FREE
  Lisa-Marie Munter, Philipp Voigt, Anja Harmeier, Daniela Kaden, Kay E Gottschalk, Christoph Weise, Rüdiger Pipkorn, Michael Schaefer, Dieter Langosch and Gerd Multhaup
  The EMBO Journal (2007), 26, - 1702–1712 | doi:10.1038/sj.emboj.7601616
  - Abstract - GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of A[beta]42
  - Full text
  - PDF (322 KB) - GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of A[beta]42
  - Supplementary information
- Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 FREE
  Ruth Scherz-Shouval, Elena Shvets, Ephraim Fass, Hagai Shorer, Lidor Gil and Zvulun Elazar
  The EMBO Journal (2007), 26, - 1749–1760 | doi:10.1038/sj.emboj.7601623
  - Abstract - Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
  - Full text
  - PDF (550 KB) - Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
  - Supplementary information
- Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cellFREE
  Takashi Sato, Seiko Susuki, Mary Ann Suico, Masanori Miyata, Yukio Ando, Mineyuki Mizuguchi, Makoto Takeuchi, Mizuki Dobashi, Tsuyoshi Shuto and Hirofumi Kai
  The EMBO Journal (2007), 26, - 2501–2512 | doi:10.1038/sj.emboj.7601685
  - Abstract - Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell
  - Full text
  - PDF (416 KB) - Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell
  - Supplementary information
- Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic miceFREE
  Aimin Li, Pedro Piccardo, Sami J Barmada, Bernardino Ghetti and David A Harris
  The EMBO Journal (2007), 26, - 2777–2785 | doi:10.1038/sj.emboj.7601726
  - Abstract - Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice
  - Full text
  - PDF (445 KB) - Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice
- SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosisFREE
  Dohoon Kim, Minh Dang Nguyen, Matthew M Dobbin, Andre Fischer, Farahnaz Sananbenesi, Joseph T Rodgers, Ivana Delalle, Joseph A Baur, Guangchao Sui, Sean M Armour, Pere Puigserver, David A Sinclair and Li-Huei Tsai
  The EMBO Journal (2007), 26, - 3169–3179 | doi:10.1038/sj.emboj.7601758
  - Abstract - SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
  - Full text
  - PDF (607 KB) - SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
  - Supplementary information
- J-protein co-chaperone Sis1 required for generation of [RNQ⁺] seeds necessary for prion propagationFREE
  Rebecca Aron, Takashi Higurashi, Chandan Sahi and Elizabeth A Craig
  The EMBO Journal (2007), 26, - 3794–3803 | doi:10.1038/sj.emboj.7601811
  - Abstract - J-protein co-chaperone Sis1 required for generation of [lsqb]: RNQ: +: [rsqb] seeds necessary for prion propagation
  - Full text
  - PDF (270 KB) - J-protein co-chaperone Sis1 required for generation of [lsqb]: RNQ: +: [rsqb] seeds necessary for prion propagation
  - Supplementary information
- The CNS glycoprotein Shadoo has PrP^C-like protective properties and displays reduced levels in prion infections EMBO Open
  Joel C Watts, Bettina Drisaldi, Vivian Ng, Jing Yang, Bob Strome, Patrick Horne, Man-Sun Sy, Larry Yoong, Rebecca Young, Peter Mastrangelo, Catherine Bergeron, Paul E Fraser, George A Carlson, Howard T J Mount, Gerold Schmitt-Ulms and David Westaway
  The EMBO Journal (2007), 26, - 4038–4050 | doi:10.1038/sj.emboj.7601830
  - Abstract - The CNS glycoprotein Shadoo has PrP: C: -like protective properties and displays reduced levels in prion infections
  - Full text
  - PDF (613 KB) - The CNS glycoprotein Shadoo has PrP: C: -like protective properties and displays reduced levels in prion infections
  - Supplementary information
- Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesisFREE
  Tiziana Anelli, Stefania Ceppi, Leda Bergamelli, Margherita Cortini, Silvia Masciarelli, Caterina Valetti and Roberto Sitia
  The EMBO Journal (2007), 26, - 4177–4188 | doi:10.1038/sj.emboj.7601844
  - Abstract - Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis
  - Full text
  - PDF (445 KB) - Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis
  - Supplementary information
- Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells EMBO Open
  Alessandra Giodini and Peter Cresswell
  The EMBO Journal (2008), 27, - 201–211 | doi:10.1038/sj.emboj.7601941
  - Abstract - Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells
  - Full text
  - PDF (286 KB) - Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells
  - Supplementary information
- Fission and selective fusion govern mitochondrial segregation and elimination by autophagyFREE
  Gilad Twig, Alvaro Elorza, Anthony J A Molina, Hibo Mohamed, Jakob D Wikstrom, Gil Walzer, Linsey Stiles, Sarah E Haigh, Steve Katz, Guy Las, Joseph Alroy, Min Wu, Bénédicte F Py, Junying Yuan, Jude T Deeney, Barbara E Corkey and Orian S Shirihai
  The EMBO Journal (2008), 27, - 433–446 | doi:10.1038/sj.emboj.7601963
  - Abstract - Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
  - Full text
  - PDF (521 KB) - Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
  - Supplementary information

Web focus: Quality Control

See also: protein quality control

The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90FREE

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A generation in vivoFREE

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathwaysFREE

Molecular chaperones and the assembly of the prion Sup35p, an in vitro studyFREE

Adaptor protein controlled oligomerization activates the AAA+ protein ClpCFREE

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesisFREE

Glycine–alanine repeats impair proper substrate unfolding by the proteasome FREE

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitmentFREE

An aging pathway controls the TrkA to p75NTR receptor switch and amyloid -peptide generationFREE

Retrovirus infection strongly enhances scrapie infectivity release in cell cultureFREE

Regulation of mitochondrial morphology through proteolytic cleavage of OPA1 FREE

A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamicsFREE

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neuronsFREE

Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagyFREE

p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradationFREE

ERp57 is essential for efficient folding of glycoproteins sharing common structural domainsFREE

Unfolded protein response in a Drosophila model for retinal degenerationFREE

m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondriaFREE

Lethal recessive myelin toxicity of prion protein lacking its central domainFREE

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105–125FREE

Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutantsFREE

Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation FREE

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of A42FREE

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 FREE

Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cellFREE

Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic miceFREE

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosisFREE

J-protein co-chaperone Sis1 required for generation of [RNQ+] seeds necessary for prion propagationFREE

The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections EMBO Open

Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesisFREE

Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells EMBO Open

Fission and selective fusion govern mitochondrial segregation and elimination by autophagyFREE

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An aging pathway controls the TrkA to p75^NTR receptor switch and amyloid -peptide generationFREE

J-protein co-chaperone Sis1 required for generation of [RNQ⁺] seeds necessary for prion propagationFREE

The CNS glycoprotein Shadoo has PrP^C-like protective properties and displays reduced levels in prion infections EMBO Open