Archive: Molecular Biology of Disease

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Molecular Biology of Disease from: 2009 Molecular Biology of Disease; 2008 Molecular Biology of Disease; 2007 Molecular Biology of Disease; 2006 Molecular Biology of Disease; 2005 Molecular Biology of Disease; 2004 Molecular Biology of Disease; 2003 Molecular Biology of Disease; 2002 Molecular Biology of Disease

| Molecular Biology of Disease
- SnoN functions as a tumour suppressor by inducing premature senescence
  Deng Pan, Qingwei Zhu and Kunxin Luo
  The EMBO Journal (2009), 28, - 3500 - 3513, doi:10.1038/emboj.2009.250
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  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- AP-2 promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene
  Christopher M J Williams, Angelo G Scibetta, J Karsten Friedrich, Monica Canosa, Chiara Berlato, Charlotte H Moss and Helen C Hurst
  The EMBO Journal (2009), 28, - 3591 - 3601, doi:10.1038/emboj.2009.290
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  Subject Category:
  - Molecular Biology of Disease
- 4E-BP1 is a target of Smad4 essential for TGF-mediated inhibition of cell proliferation
  Rania Azar, Amandine Alard, Christiane Susini, Corinne Bousquet and Stéphane Pyronnet
  The EMBO Journal (2009), 28, - 3514 - 3522, doi:10.1038/emboj.2009.291
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  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- Pre-fibrillar -synuclein variants with impaired -structure increase neurotoxicity in Parkinson's disease models
  Damla Pinar Karpinar, Madhu Babu Gajula Balija, Sebastian Kügler, Felipe Opazo, Nasrollah Rezaei-Ghaleh, Nora Wender, Hai-Young Kim, Grit Taschenberger, Björn H Falkenburger, Henrike Heise, Ashutosh Kumar, Dietmar Riedel, Lars Fichtner, Aaron Voigt, Gerhard H Braus, Karin Giller, Stefan Becker, Alf Herzig, Marc Baldus, Herbert Jäckle, Stefan Eimer, Jörg B Schulz, Christian Griesinger and Markus Zweckstetter
  The EMBO Journal (2009), 28, - 3256 - 3268, doi:10.1038/emboj.2009.257
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  Subject Categories:
  - Molecular Biology of Disease | Structural Biology
- MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication
  Xiaohua Xu, Patrick J Rochette, Eminet A Feyissa, Tina V Su and Yilun Liu
  The EMBO Journal (2009), 28, - 3005 - 3014, doi:10.1038/emboj.2009.235
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  Subject Categories:
  - Genome Stability and Dynamics | Molecular Biology of Disease
- FoxM1, a critical regulator of oxidative stress during oncogenesis FREE
  Hyun Jung Park, Janai R Carr, Zebin Wang, Veronique Nogueira, Nissim Hay, Angela L Tyner, Lester F Lau, Robert H Costa and Pradip Raychaudhuri
  The EMBO Journal (2009), 28, - 2908 - 2918, doi:10.1038/emboj.2009.239
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  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis
  Ruifang Li, Hua Zhang, Wenhua Yu, Yupeng Chen, Bin Gui, Jing Liang, Yan Wang, Luyang Sun, Xiaohan Yang, Yu Zhang, Lei Shi, Yanyan Li and Yongfeng Shang
  The EMBO Journal (2009), 28, - 2763 - 2776, doi:10.1038/emboj.2009.211
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  Subject Categories:
  - Chromatin and Transcription | Molecular Biology of Disease
- Telomeres and disease FREE
  Peter M Lansdorp
  The EMBO Journal (2009), 28, - 2532 - 2540, doi:10.1038/emboj.2009.172
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  Subject Category:
  - Molecular Biology of Disease
- The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
  Sandrine Marchetti, Parvati Gamas, Nathalie Belhacène, Sebastien Grosso, Ludivine A Pradelli, Pascal Colosetti, Claus Johansen, Lars Iversen, Marcel Deckert, Fréderic Luciano, Paul Hofman, Nicolas Ortonne, Abdallah Khemis, Bernard Mari, Jean-Paul Ortonne, Jean-Ehrland Ricci and Patrick Auberger
  The EMBO Journal (2009), 28, - 2449 - 2460, doi:10.1038/emboj.2009.183
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  Subject Category:
  - Molecular Biology of Disease
- Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy
  Isabelle Vergne, Esteban Roberts, Rasha A Elmaoued, Valérie Tosch, Mónica A Delgado, Tassula Proikas-Cezanne, Jocelyn Laporte and Vojo Deretic
  The EMBO Journal (2009), 28, - 2244 - 2258, doi:10.1038/emboj.2009.159
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  Subject Categories:
  - Differentiation and Death | Molecular Biology of Disease
- JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
  Rocio Sancho, Abdolrahman S Nateri, Amaya Garcia de Vinuesa, Cristina Aguilera, Emma Nye, Bradley Spencer-Dene and Axel Behrens
  The EMBO Journal (2009), 28, - 1843 - 1854, doi:10.1038/emboj.2009.153
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  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
  Yuxin Mao, Daniel M Balkin, Roberto Zoncu, Kai S Erdmann, Livia Tomasini, Fenghua Hu, Moonsoo M Jin, Michael E Hodsdon and Pietro De Camilli
  The EMBO Journal (2009), 28, - 1831 - 1842, doi:10.1038/emboj.2009.155
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  Subject Categories:
  - Membranes and Transport | Molecular Biology of Disease
- Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity FREE
  Juxiang Cao, Jennifer Schulte, Alexander Knight, Nicholas R Leslie, Agnieszka Zagozdzon, Roderick Bronson, Yefim Manevich, Craig Beeson and Carola A Neumann
  The EMBO Journal (2009), 28, - 1505 - 1517, doi:10.1038/emboj.2009.101
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  Subject Category:
  - Molecular Biology of Disease
- Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development FREE
  Stefan G Lechner, Henning Frenzel, Rui Wang and Gary R Lewin
  The EMBO Journal (2009), 28, - 1479 - 1491, doi:10.1038/emboj.2009.73
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  Subject Categories:
  - Development | Molecular Biology of Disease
- Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis
  Paloma García, Mary Clarke, Alexandros Vegiopoulos, Oscar Berlanga, Ana Camelo, Maelle Lorvellec and Jon Frampton
  The EMBO Journal (2009), 28, - 1492 - 1504, doi:10.1038/emboj.2009.97
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  Subject Categories:
  - Differentiation and Death | Molecular Biology of Disease
- Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 FREE
  Martin Gamerdinger, Parvana Hajieva, A Murat Kaya, Uwe Wolfrum, F Ulrich Hartl and Christian Behl
  The EMBO Journal (2009), 28, - 889 - 901, doi:10.1038/emboj.2009.29
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  Subject Categories:
  - Proteins | Molecular Biology of Disease
- ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis
  Takayuki Iriyama, Kohsuke Takeda, Hiromi Nakamura, Yoshifumi Morimoto, Takumi Kuroiwa, Junya Mizukami, Tsuyoshi Umeda, Takuya Noguchi, Isao Naguro, Hideki Nishitoh, Kaoru Saegusa, Kei Tobiume, Toshiki Homma, Yutaka Shimada, Hitoshi Tsuda, Satoshi Aiko, Issei Imoto, Johji Inazawa, Kazuhiro Chida, Yoshimasa Kamei, Shiro Kozuma, Yuji Taketani, Atsushi Matsuzawa and Hidenori Ichijo
  The EMBO Journal (2009), 28, - 843 - 853, doi:10.1038/emboj.2009.32
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  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers FREE
  Barbara Stecca and Ariel Ruiz i Altaba
  The EMBO Journal (2009), 28, - 663 - 676, doi:10.1038/emboj.2009.16
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  Subject Categories:
  - Development | Molecular Biology of Disease
- A multifunctional serine protease primes the malaria parasite for red blood cell invasion FREE
  Konstantinos Koussis, Chrislaine Withers-Martinez, Sharon Yeoh, Matthew Child, Fiona Hackett, Ellen Knuepfer, Luiz Juliano, Ute Woehlbier, Hermann Bujard and Michael J Blackman
  The EMBO Journal (2009), 28, - 725 - 735, doi:10.1038/emboj.2009.22
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  Subject Categories:
  - Microbiology and Pathogens | Molecular Biology of Disease
- Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF
  Deo Prakash Pandey, Rosamaria Lappano, Lidia Albanito, Antonio Madeo, Marcello Maggiolini and Didier Picard
  The EMBO Journal (2009), 28, - 523 - 532, doi:10.1038/emboj.2008.304
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  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- TRPP2 channels regulate apoptosis through the Ca²⁺ concentration in the endoplasmic reticulum
  Tomasz Wegierski, Daniel Steffl, Christoph Kopp, Robert Tauber, Björn Buchholz, Roland Nitschke, E Wolfgang Kuehn, Gerd Walz and Michael Köttgen
  The EMBO Journal (2009), 28, - 490 - 499, doi:10.1038/emboj.2008.307
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  Subject Categories:
  - Membranes and Transport | Molecular Biology of Disease
- Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3
  Sokol V Todi, Brett J Winborn, K Matthew Scaglione, Jessica R Blount, Sue M Travis and Henry L Paulson
  The EMBO Journal (2009), 28, - 372 - 382, doi:10.1038/emboj.2008.289
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  - PDF (1,591 KB) -
  - Supplementary information
  Subject Categories:
  - Proteins | Molecular Biology of Disease
- Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7
  Surabhi Dangi-Garimella, Jieun Yun, Eva M Eves, Martin Newman, Stefan J Erkeland, Scott M Hammond, Andy J Minn and Marsha Rich Rosner
  The EMBO Journal (2009), 28, - 347 - 358, doi:10.1038/emboj.2008.294
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  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4
  Jana Mazelova, Lisa Astuto-Gribble, Hiroki Inoue, Beatrice M Tam, Eric Schonteich, Rytis Prekeris, Orson L Moritz, Paul A Randazzo and Dusanka Deretic
  The EMBO Journal (2009), 28, - 183 - 192, doi:10.1038/emboj.2008.267
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  - PDF (1,771 KB) -
  - Supplementary information
  Subject Categories:
  - Membranes and Transport | Molecular Biology of Disease
- TGF-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGF switch
  Irwin M Liu, Stephen H Schilling, Kristin A Knouse, Lisa Choy, Rik Derynck and Xiao-Fan Wang
  The EMBO Journal (2008), 28, - 88 - 98, doi:10.1038/emboj.2008.266
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  - PDF (924 KB) -
  - Supplementary information
  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease
- PTEN regulation by Akt–EGR1–ARF–PTEN axis FREE
  Jianxiu Yu, Sharon S Zhang, Kan Saito, Scott Williams, Yutaka Arimura, Yuliang Ma, Yuehai Ke, Veronique Baron, Dan Mercola, Gen-Sheng Feng, Eileen Adamson and Tomas Mustelin
  The EMBO Journal (2009), 28, - 21 - 33, doi:10.1038/emboj.2008.238
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  Subject Categories:
  - Chromatin and Transcription | Molecular Biology of Disease
- Cancer induction by restriction of oncogene expression to the stem cell compartment FREE
  María Pérez-Caro, César Cobaleda, Inés González-Herrero, Carolina Vicente-Dueñas, Camino Bermejo-Rodríguez, Margarita Sánchez-Beato, Alberto Orfao, Belén Pintado, Teresa Flores, Manuel Sánchez-Martín, Rafael Jiménez, Miguel A Piris and Isidro Sánchez-García
  The EMBO Journal (2009), 28, - 8 - 20, doi:10.1038/emboj.2008.253
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  - PDF (2,189 KB) -
  - Supplementary information
  Subject Categories:
  - Signal Transduction | Molecular Biology of Disease

Archive: Molecular Biology of Disease

| Molecular Biology of Disease

SnoN functions as a tumour suppressor by inducing premature senescence

Subject Categories:

AP-2 promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene

Subject Category:

4E-BP1 is a target of Smad4 essential for TGF-mediated inhibition of cell proliferation

Subject Categories:

Pre-fibrillar -synuclein variants with impaired -structure increase neurotoxicity in Parkinson's disease models

Subject Categories:

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication

Subject Categories:

FoxM1, a critical regulator of oxidative stress during oncogenesis FREE

Subject Categories:

ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis

Subject Categories:

Telomeres and disease FREE

Subject Category:

The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice

Subject Category:

Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy

Subject Categories:

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

Subject Categories:

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

Subject Categories:

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity FREE

Subject Category:

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development FREE

Subject Categories:

Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis

Subject Categories:

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 FREE

Subject Categories:

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Subject Categories:

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers FREE

Subject Categories:

A multifunctional serine protease primes the malaria parasite for red blood cell invasion FREE

Subject Categories:

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

Subject Categories:

TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum

Subject Categories:

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

Subject Categories:

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

Subject Categories:

Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Subject Categories:

TGF-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGF switch

Subject Categories:

PTEN regulation by Akt–EGR1–ARF–PTEN axis FREE

Subject Categories:

Cancer induction by restriction of oncogene expression to the stem cell compartment FREE

Subject Categories:

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TRPP2 channels regulate apoptosis through the Ca²⁺ concentration in the endoplasmic reticulum