Abstract
The prevalence of multiple sclerosis in Sardinia is significantly higher than in neighbouring Mediterranean countries, suggesting that the isolated growth of the population has concentrated genetic factors which increase susceptibility to the disease. The distinct HLA association of multiple sclerosis in Sardinia supports this interpretation. We have performed a whole genome screen for linkage in 49 Sardinian multiplex families using 327 markers. Non parametric linkage analysis of these data reveal suggestive linkage in the region of Chr 1q31, Chr 10q23 and Chr 11p15.
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Acknowledgements
We thank the members of Professor Marrosu's laboratory for help in collecting and extracting the DNA samples from the Sardinian multiplex families and Julia Gray, Belinda Smillie and Mel Maranian for technical support during this study. The DNA collection has been supported by a grant from the Associazione Italian Sclerosi Multipla. We are grateful to the Wellcome Trust for financial support. F. Coraddu is supported by a Wellcome Trust grant and received a Sackler Award from the University of Cambridge.
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Coraddu, F., Sawcer, S., D'Alfonso, S. et al. A genome screen for multiple sclerosis in Sardinian multiplex families. Eur J Hum Genet 9, 621–626 (2001). https://doi.org/10.1038/sj.ejhg.5200680
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DOI: https://doi.org/10.1038/sj.ejhg.5200680
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