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European Journal of Human Genetics (2008) 16, 762–765; doi:10.1038/ejhg.2008.4; published online 13 February 2008

Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

Ronald E Blanton1, Luciano K Silva2, Vanessa G Morato3, Antonio R Parrado4, Juarez P Dias5, Paulo R S Melo2, Eliana A G Reis2, Katrina A B Goddard4, Márcio R T Nunes6, Sueli G Rodrigues6, Pedro F C Vasconcelos6, Jesuina M Castro5, Mitermayer G Reis2, Maurício L Barreto3 and M Glória Teixeira3

  1. 1Case Western Reserve University, Center for Global Health and Diseases, Cleveland, OH, USA
  2. 2Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz, Laboratory of Pathology and Molecular Biology, Rua Waldemar Falcão, 121, Salvador, Bahia, Brazil
  3. 3Universidade Federal da Bahia, Institute of Collective Health, Salvador, Bahia, Brazil
  4. 4Case Western Reserve University, Division of Genetic Epidemiology, Department of Epidemiology & Biostatistics, Wolstein Research Building, Cleveland, OH, USA
  5. 5Secretaria da Saúde do Estado da Bahia, 4a Avenida do CAB, no 400, Lado B, CAB, Salvador, Bahia, Brazil
  6. 6Instituto Evandro Chagas, Department of Arbovirology and Hemorrhagic Fever, Belém, Pará, Brazil

Correspondence: Dr R Blanton, Center for Global Health and Disease, Case University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106-7286, USA. Tel: +1 216 368 4814; Fax: +1 216 368 4825; E-mail: reb6@case.edu

Received 24 April 2007; Revised 15 December 2007; Accepted 6 January 2008; Published online 13 February 2008.

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Abstract

To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.

Keywords:

ethnicity, race, population structure, socioeconomic status, DENV3

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