European Journal of Human Genetics

TABLE 1

FROM:

Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks

Colin N Moran, Nan Yang, Mark E S Bailey, Athanasios Tsiokanos, Athanasios Jamurtas, Daniel G MacArthur, Kathryn North, Yannis P Pitsiladis and Richard H Wilson

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Table 1. ANOVA analysis of associations between R577X genotype and body composition-, strength/power- and endurance-related phenotypes in male and female subjects

  Total males (N=172,242,93) Total females (N=151,215,73)
Body composition   
 BMI (kgm-2)RR=23.4 (22.8–23.9)RR=21.9 (21.5–22.3)
 RX=23.5 (23.0–23.9)RX=22.3 (21.9–22.6)
 XX=23.2 (22.5–23.9)XX=22.0 (21.5–22.5)
  V=0.1%, P=0.791 V=0.5%, P=0.332
   
 Triceps skinfolds (mm)RR=11.1 (10.3–11.8)RR=16.7 (15.8–17.6)
 RX=11.6 (10.9–12.3)RX=17.6 (17.0–18.3)
 XX=11.8 (10.8–13.0)XX=17.4 (16.3–18.6)
  V=0.3%, P=0.492 V=0.6%, P=0.234
   
 Subscapular skinfolds (mm)RR=11.4 (10.8–12.1)RR=13.0 (12.4–13.7)
 RX=11.7 (11.1–12.4)RX=13.6 (13.0–14.2)
 XX=11.5 (10.5–12.5)XX=13.3 (12.5–14.3)
  V=0.1%, P=0.799 V=0.4%, P=0.392
   
Strength/power-related   
 Handgrip strength (kg)RR=80.3 (77.7–82.9)RR=49.7 (48.2–51.2)
 RX=80.6 (78.8–82.5)RX=49.8 (48.5–51.1)
 XX=78.4 (75.8–81.2)XX=49.7 (47.7–51.7)
  V=0.3%, P=0.488 V=0%, P=0.990
   
 Basketball throw (m)RR=6.87 (6.70–7.04)RR=4.52 (4.42–4.63)
 RX=6.75 (6.61–6.89)RX=4.47 (4.38–4.56)
 XX=6.88 (6.64–7.13)XX=4.64 (4.50–4.77)
  V=0.3%, P=0.475 V=0.8%, P=0.159
   
 Vertical jump (cm)RR=45.0 (43.9–46.1)RR=31.2 (30.6–31.9)
 RX=44.5 (43.5–45.4)RX=30.5 (29.9–31.2)
 XX=43.4 (42.2–44.6)XX=31.2 (30.3–32.1)
  V=0.6%, P=0.203 V=0.5%, P=0.291
   
 40 m Sprint (s) RR=5.92 (5.855.99) RR=7.43 (7.33–7.52)
  RX=6.00 (5.946.06) RX=7.47 (7.39–7.55)
  XX=6.13 (6.046.22) XX=7.51 (7.38–7.65)
  V=2.3%, P=0.003 V=0.3%, P=0.567
   
 Agility run (s)RR=18.8 (18.7–19.0)RR=21.2 (20.9–21.4)
 RX=18.9 (18.7–19.0)RX=21.2 (21.0–21.5)
 XX=19.1 (18.8–19.3)XX=21.4 (21.0–21.7)
  V=0.4%, P=0.374 V=0.2%, P=0.674
   
Aerobic capacity   
 VO2 max (mlkg-1min-1)RR=38.0 (37.0–39.1)RR=30.1 (29.4–30.7)
 RX=36.7 (35.8–37.7)RX=30.1 (29.5–30.6)
 XX=37.9 (36.4–39.5)XX=29.3 (28.5–30.1)
  V=0.7%, P=0.151 V=0.5%, P=0.316

 No. of individuals of each genotype is given in the column headings (for RR, RX and XX genotypes, respectively). For each test, means and their 95% confidence intervals are shown (to 3 significant figures) for each genotype as well as percentage variance explained in ANOVA (V) and its associated probability (P). The reported means and confidence intervals have been converted back from z-scores (used for age-correction) to the equivalent measurements in 17- to 18-year-olds. Tests significant after a Sidak correction (P<0.004) are shown in bold. Note that smaller values for 40 m sprint and agility run are faster.

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