FIGURE 1
FROM:
Array comparative genomic hybridization in patients with congenital diaphragmatic hernia: mapping of four CDH-critical regions and sequencing of candidate genes at 15q26.1–15q26.2
Anne M Slavotinek, Ali Moshrefi, Randy Davis, Elizabeth Leeth, G Bradley Schaeffer, González Esteban Burchard, Gary M Shaw, Bristow James, Louis Ptacek and Len A Pennacchio
BACK TO ARTICLEFigure 1.
Array CGH in a male with a diaphragmatic hernia and a 15q26.2 deletion resulting from an unbalanced translocation (karyotype 46,XY,der(15)t(8;15)(q24.2;q26.2)). Each dot corresponds to a genomic region on chromosome 15q, with each spot being 1.4 Mb apart and covering 150 kb on average. The Y-axis shows the log2 ratios of the total integrated Cy3 and Cy5 intensities for each clone from a hybridization of patient and control DNA. A value of -1.0 is suggestive of reduced copy number for patient DNA caused by a chromosome deletion. BAC clone RP11-185D5 has a copy number of -0.745, suggestive of a 15q deletion from this clone that extends to the 15q telomere.
