TABLE 2
FROM:
Analysing DNA patents in relation with diagnostic genetic testing
Birgit Verbeure, Gert Matthijs and Geertrui Van Overwalle
BACK TO ARTICLETable 2. Listing of a set of hereditary diseases and their genes (as indicated on Genetest website and OMIM entries) taken up in the pilot study
| Disease | Gene | European patents | US patents |
|---|---|---|---|
| Achondroplasia | FGFR3 | One application | — |
| Alzheimer (late-onset) | APO-E | Six granted patents | Five granted |
| Canavan | ACY2 | — | One granted, one application |
| Gaucher | GBA | Two applications (one refused, one withdrawn) | Two granted |
| Hereditary breast and ovarian cancer | BRCA1 | Five granted (one revoked and two amended after opposition procedures), five applications (one withdrawn) | 15 granted, seven applications |
| BRCA2 | Two granted (one amended) three applications | Four granted, one application | |
| Hereditary hemochromatosis | HFE | One granted, seven applications | Six granted, |
| TFR2 | Two applications | Seven applications | |
| Ferroportin | One application | ||
| Hereditary nonpolyposis colorectal cancer (HNPCC) | MLH genes MSH genes PMS genes | Four applications | Eight granted, 10 applications |
| Huntington | HD | One granted, one application (withdrawn) | Two granted |
| Neurofibromatosis | NF1 | Two applications | Four granted, one application |
| NF2 | One granted | One granted | |
| Tuberous sclerosis | TSC1 | — | Two granted |
| TSC2 | One application | Two granted | |
| Short stature | SHOX | One granted | One application |
The patent count includes all patents that could affect genetic diagnostic testing based on the cited genes thus including patents with product claims on the gene itself or mutated forms, as well as diagnostic methods or kits involving the gene (last updated 16 August 2005).
