European Journal of Human Genetics

FIGURE 2

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DFNB40, a recessive form of sensorineural hearing loss, maps to chromosome 22q11.21–12.1

Sedigheh Delmaghani, Asadollah Aghaie, Sylvie Compain-Nouaille, Afsaneh Ataie, Arnaud Lemainque, Sirous Zeinali, Mark Lathrop, Dominique Weil and Christine Petit

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Figure 2.

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Segregation analysis with chromosome 22q11–q12 polymorphic microsatellite markers. Deaf individuals are indicated by filled symbols and unaffected individuals by open symbols. The 'at risk' haplotypes inherited from generation III are boxed in all generation IV individuals. The smallest region of homozygosity associated with the mutated DFNB40 allele is boxed on the left side of the figure. For each polymorphic marker, the physical distance to the centromere is indicated on the left, and the calculated lod score is indicated on the right. The DFNB40 critical interval, between D22S427 and D22S1144, spans 8.8 Mb.

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