Short Report
European Journal of Human Genetics (2003) 11, 812–815. doi:10.1038/sj.ejhg.5201041
DFNB39, a recessive form of sensorineural hearing impairment, maps to chromosome 7q11.22–q21.12
Muhammad Wajid1, Amir Ali Abbasi1, Muhammad Ansar1, Thanh L Pham2, Kai Yan2, Sayedul Haque1, Wasim Ahmad1 and Suzanne M Leal2
- 1Department of Biological Sciences, Quaid-I-Azam University Islamabad, Pakistan
- 2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
Correspondence: Dr SM Leal, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Tel: +713 798-4011; Fax: +713 7984 373; E-mail: sleal@bcm.tmc.edu
Received 2 October 2002; Revised 10 April 2003; Accepted 14 April 2003.
Abstract
This article describes the identification of a novel locus (DFNB39) responsible for an autosomal recessive form of hearing loss segregating in a Pakistani consanguineous family. The hearing impaired members of this family present with profound prelingual sensorineural hearing impairment and use sign language for communications. Linkage was established to microsatellite markers located on chromosome 7q with a maximum multipoint lod score of 3.8. The region of homozygosity spans a 19 cM region that is bounded by markers D7S3046 and D7S644.
Keywords:
autosomal recessive nonsyndromic hearing impairment, DFNB39, linkage mapping, Pakistan, 7q11.22–q21.12
