Original Article
European Journal of Clinical Nutrition advance online publication 11 November 2009; doi: 10.1038/ejcn.2009.130
Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study
P Detopoulou1, D B Panagiotakos1, C Chrysohoou2, E Fragopoulou1, T Nomikos1, S Antonopoulou1, C Pitsavos2 and C Stefanadis2
- 1Department of Nutrition—Dietetics, Harokopio University, Athens, Greece
- 2First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
Correspondence: Professor DB Panagiotakos, Department of Nutrition-Dietetics, Harokopio University, 46 Paleon Polemiston St Glyfada, Kallithea, Attica 17671, Greece. E-mail: d.b.panagiotakos@usa.net
Received 10 April 2009; Revised 22 September 2009; Accepted 2 October 2009; Published online 11 November 2009.
Abstract
Background/Objectives:
This study aimed at evaluating the relationship of adiponectin concentration with total dietary antioxidant capacity in free-living, apparently healthy adults from the ATTICA study.
Subjects/Methods:
A random subsample from the ATTICA study, consisting of 310 men (40
11 years) and 222 women (3812 years), was selected. Adiponectin, along with other inflammatory markers, was measured in fasting participants. Dietary habits were evaluated using a food frequency questionnaire and the dietary antioxidant capacity was based on published values of Italian foods measured by three different assays: ferric-reducing antioxidant power (FRAP), total radical-trapping antioxidant parameters (TRAP) and trolox-equivalent antioxidant capacity (TEAC).
Results:
Positive associations were observed between dietary antioxidant capacity and adiponectin concentration, as assessed with FRAP (bs.e.=0.0120.005, P=0.018 per 1 mmol Fe (II)/day), TRAP (bs.e.=0.0300.013, P=0.017 per 1 mmol trolox equivalent/day) and TEAC (bs.e.=0.0250.012, P=0.042, per 1 mmol trolox equivalent/day) in multiadjusted analysis. Moreover, a negative relation of dietary antioxidant indices with inflammatory markers was revealed.
Conclusions:
Diets with high antioxidant capacity are related to increased adiponectin levels. An adiponectin-mediated route through which antioxidant-rich foods exert beneficial effects against inflammation and cardiovascular diseases can be thus hypothesized.
Keywords:
adiponectin, diet, antioxidant capacity, inflammation
