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A decrease in blood cholesterol after gastrostomy could impact survival in ALS

European Journal of Clinical Nutrition volume 71, pages 1133–1135 (2017)Cite this article

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Abstract

Although the global benefits of gastrostomy have been proven in amyotrophic lateral sclerosis (ALS), the impact on biological parameters has not been explored yet. The aim of this preliminary work was to evaluate the modification of biological parameters in patients with ALS undergoing gastrostomy. We retrospectively collected clinical and biological data from 44 patients having undergone gastrostomy at three time points (T0, T1 and T2: before, at the time of and after gastrostomy). We examined the relationship between the biological parameters and disease progression. Variations of the concentrations of total cholesterol significantly differed before (T1–T0) vs those after gastrostomy (T2–T1; P=0.0044). The variations of total cholesterol and low-density lipoprotein cholesterol concentrations after gastrostomy were negatively associated with survival (P=0.0002). This study showed for the first time that patients with ALS fed quite exclusively by gastrostomy had decreased blood cholesterol after gastrostomy. We suggest that a restoration of normal lipid metabolism should be planned in patients with ALS.

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Acknowledgements

Author contributions

HB, PC and PCou were involved in the conceptualisation and design of the study. OLT, SM and SB were involved in the acquisition of the data. Statistical analysis was conducted by HB and FP. HB wrote the first version of the manuscript. HB, PC, PCou, CRA, PV and VM were involved in the interpretation of data for the work and revised the manuscript critically for important intellectual content.

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Authors and Affiliations

  1. UMR INSERM U930, Equipe Neurogénétique et Neurométabolomique, Université François Rabelais,, Tours, France

    H Blasco, F Patin, P Vourc'h, C R Andres & P Corcia

  2. Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, CHRU de Tours, Tours, France

    H Blasco, F Patin, S Molinier, P Vourc'h, O Le Tilly & C R Andres

  3. CHRU de Tours, Fédération des CRCSLA Tours-Limoges, LITORALS, Tours, France

    S Bakkouche, V Meininger, P Couratier & P Corcia

  4. UMR 1094, Limoges,

    P Couratier

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  1. H Blasco
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  2. F Patin
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  10. P Corcia
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Correspondence to H Blasco.

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Blasco, H., Patin, F., Molinier, S. et al. A decrease in blood cholesterol after gastrostomy could impact survival in ALS. Eur J Clin Nutr 71, 1133–1135 (2017). https://doi.org/10.1038/ejcn.2017.54

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  • DOI: https://doi.org/10.1038/ejcn.2017.54

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