Original Article

European Journal of Clinical Nutrition (2011) 65, 240–246; doi:10.1038/ejcn.2010.235; published online 27 October 2010

Gastrointestinal transit, post-prandial lipaemia and satiety following 3 days high-fat diet in men

M E Clegg1,2, P McKenna1, C McClean3, G W Davison3, T Trinick4, E Duly4 and A Shafat1

  1. 1Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland, UK
  2. 2School of Life Sciences, Functional Food Centre, Oxford Brookes University, Oxford, UK
  3. 3Sport and Exercise Sciences Research Institute, University of Ulster, Belfast, Northern Ireland, UK
  4. 4Ulster Hospital, Dundonald, Northern Ireland, UK

Correspondence: Dr A Shafat, Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, University of Limerick, Castletroy, Limerick 0000, Ireland. E-mail: amir.shafat@ul.ie

Received 22 June 2010; Revised 7 September 2010; Accepted 20 September 2010; Published online 27 October 2010.





High-fat (HF) diets of 2 weeks have been shown to accelerate gastric emptying (GE). To date, no studies have shown any alteration in GE following shorter HF diets. The aim of this study was to assess if an HF, high-energy diet of 3 days can adapt gastrointestinal (GI) transit, blood lipids and satiety.



Eleven male volunteers participated in a study consisting of three, 3-day interventions each separated by a test day. During the first intervention, volunteers recorded their diet. In the second and third interventions, volunteers repeated their food diary plus either a low-fat yogurt or HF yogurt supplement in randomized order. Test days involved measurement of GE using the 13C octanoic-acid breath-test, mouth-to-caecum transit time (MCTT) using the inulin H2 breath test and satiety using visual analogue scales. Blood samples for measurement of lipaemia were taken using a venous cannula.



MCTT was different between the three test days (P=0.038), with the shortest MCTT following the HF intervention. GE was shortest following the HF intervention. There were no differences in satiety between the interventions. The HF intervention reduced triglycerides, total cholesterol and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol.



This study shows that changes in GI transit owing to an HF diet can occur in a time period as short as 3 days.


gastric emptying; lipaemia; mouth-to-caecum transit time; satiety

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