Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

The influence of caffeine on energy content of sugar-sweetened beverages: ‘the caffeine–calorie effect’

Abstract

Background/Objectives:

Caffeine is a mildly addictive psychoactive chemical and controversial additive to sugar-sweetened beverages (SSBs). The objective of this study is to assess if removal of caffeine from SSBs allows co-removal of sucrose (energy) without affecting flavour of SSBs, and if removal of caffeine could potentially affect population weight gain.

Subjects/Methods:

The research comprised of three studies; study 1 used three-alternate forced choice and paired comparison tests to establish detection thresholds for caffeine in water and sucrose solution (subjects, n=63), and to determine if caffeine suppressed sweetness. Study 2 (subjects, n=30) examined the proportion of sucrose that could be co-removed with caffeine from SSBs without affecting the flavour of the SSBs. Study 3 applied validated coefficients to estimate the impact on the weight of the United States population if there was no caffeine in SSBs.

Results:

Detection threshold for caffeine in water was higher (1.09±0.08 mM) than the detection threshold for caffeine in sucrose solution (0.49±0.04 mM), and a paired comparison test revealed caffeine significantly reduced the sweetness of sucrose (P<0.001). Removing caffeine from SSBs allowed co-removal of 10.3% sucrose without affecting flavour of the SSBs, equating to 116 kJ per 500 ml serving. The effect of this on body weight in adults and children would be 0.600 and 0.142 kg, which are equivalent to 2.08 and 1.10 years of observed existing trends in weight gain, respectively.

Conclusion:

These data suggest the extra energy in SSBs as a result of caffeine's effect on sweetness may be associated with adult and child weight gain.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  • Bartoshuk LM (2000). Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem Senses 25, 447–460.

    Article  CAS  Google Scholar 

  • Bleich SN, Wang YC, Wang Y, Gortmaker SL (2009). Increasing consumption of sugar-sweetened beverages among US adults: 1988–1994 to 1999–2004. Am J Clin Nutr 89, 372–381.

    Article  CAS  Google Scholar 

  • CDC (2004). Mean body weight, height, and body mass index, United States 1960–2002 (online). US Department of Health and Human Services. Available at: http://www.cdc.gov/nchs/data/ad/ad347.pdf (accessed February 2009)

  • Datamonitor (2007). Carbonated Soft Drinks in the United States (online). Available at: http://www.reportlinker.com/p0147225/Carbonated-Soft-Drinks-in-the-United-States.html (accessed).

  • Delwiche JF, Buletic Z, Breslin PA (2001). Covariation in individuals’ sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms. Percept Psychophys 63, 761–776.

    Article  CAS  Google Scholar 

  • DiMeglio DP, Mattes RD (2000). Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes Relat Metab Disord 24, 794–800.

    Article  CAS  Google Scholar 

  • Ebbeling CB, Feldman HA, Osganian SK, Chomitz VR, Ellenbogen SJ, Ludwig DS (2006). Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study. Pediatrics 117, 673–680.

    Article  Google Scholar 

  • Egger G, Swinburn B, Rossner S (2003). Dusting off the epidemiological triad: could it work with obesity? Obes Rev 4, 115–119.

    Article  CAS  Google Scholar 

  • Garrett BE, Griffiths RR (1998). Physical dependence increases the relative reinforcing effects of caffeine versus placebo. Psychopharmacology (Berl) 139, 195–202.

    Article  CAS  Google Scholar 

  • Green BG, Frankmann SP (1988). The effect of cooling on the perception of carbohydrate and intensive sweeteners. Physiol Behav 43, 515–519.

    Article  CAS  Google Scholar 

  • Griffiths RR, Vernotica EM (2000). Is caffeine a flavoring agent in cola soft drinks? Arch Fam Med 9, 727–734.

    Article  CAS  Google Scholar 

  • Griffiths RR, Woodson PP (1988). Reinforcing effects of caffeine in humans. J Pharmacol Exp Ther 246, 21–29.

    CAS  PubMed  Google Scholar 

  • Harrington S (2008). The role of sugar-sweetened beverage consumption in adolescent obesity: a review of the literature. J Sch Nurs 24, 3–12.

    Article  Google Scholar 

  • Hayes JE, Duffy VB (2007). Revisiting sugar-fat mixtures: sweetness and creaminess vary with phenotypic markers of oral sensation. Chem Senses 32, 225–236.

    Article  CAS  Google Scholar 

  • Hughes JR, Oliveto AH, Bickel WK, Higgins ST, Badger GJ (1993). Caffeine self-administration and withdrawal: incidence, individual differences and interrelationships. Drug Alcohol Depend 32, 239–246.

    Article  CAS  Google Scholar 

  • James J, Kerr D (2005). Prevention of childhood obesity by reducing soft drinks. Int J Obes (Lond) 29 (Suppl 2), S54–S57.

    Article  Google Scholar 

  • Keast RSJ, Riddell LJ (2007). Caffeine as a flavor additive in soft-drinks. Appetite 49, 255–259.

    Article  CAS  Google Scholar 

  • Keast RSJ, Roper J (2007). A complex relationship among chemical concentration, detection threshold, and suprathreshold intensity of bitter compounds. Chem Senses 32, 245–253.

    Article  CAS  Google Scholar 

  • Krachler B, Eliasson M, Stenlund H, Johansson I, Hallmans G, Lindahl B (2006). Reported food intake and distribution of body fat: a repeated cross-sectional study. Nutr J 5, 34.

    Article  Google Scholar 

  • Ludwig DS, Peterson KE, Gortmaker SL (2001). Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 357, 505–508.

    Article  CAS  Google Scholar 

  • McBride RL (1983). A JND-scale/category-scale convergence in taste. Percept Psychophys 34, 77–83.

    Article  CAS  Google Scholar 

  • McGartland C, Robson PJ, Murray L, Cran G, Savage MJ, Watkins D et al. (2003). Carbonated soft drink consumption and bone mineral density in adolescence: the Northern Ireland Young Hearts project. J Bone Miner Res 18, 1563–1569.

    Article  CAS  Google Scholar 

  • Meilgaard M, Civille G, Carr B (2007). Sensory Evaluation Techniques. CRC Press: Boca Raton.

    Google Scholar 

  • PepsiCo I (1981). The physical or technical effects in cola beverages. In Vol III, Appendix XII of comment of the National Soft Drink Association submitted to the department of Health and Human Services Food and Drug Administration in response to the proposal to delete caffeine in cola-type beverage from the list of generally regarded as safe and to issue an interium food additive regulation governing its future use; FDA Docket No. 80N-0418.

  • Reid M, Hammersley R, Hill AJ, Skidmore P (2007). Long-term dietary compensation for added sugar: effects of supplementary sucrose drinks over a 4-week period. Br J Nutr 97, 193–203.

    Article  CAS  Google Scholar 

  • Rolls BJ (2009). The relationship between dietary energy density and energy intake. Physiol Behav 97, 609–615.

    Article  CAS  Google Scholar 

  • Rolls BJ (2010). Plenary Lecture 1: dietary strategies for the prevention and treatment of obesity. Proc Nutr Soc 69, 70–79.

    Article  Google Scholar 

  • Schuh KJ, Griffiths RR (1997). Caffeine reinforcement: the role of withdrawal. Psychopharmacology (Berl) 130, 320–326.

    Article  CAS  Google Scholar 

  • Striegel-Moore RH, Thompson D, Affenito SG, Franko DL, Obarzanek E, Barton BA et al. (2006). Correlates of beverage intake in adolescent girls: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 148, 183–187.

    Article  Google Scholar 

  • Sun M (1980). FDA caffeine decision too early, some say. Science 209, 1500.

    PubMed  Google Scholar 

  • Swinburn BA, Caterson I, Seidell JC, James WP (2004). Diet, nutrition and the prevention of excess weight gain and obesity. Public Health Nutr 7, 123–146.

    CAS  PubMed  Google Scholar 

  • Swinburn BA, Jolley D, Kremer PJ, Salbe AD, Ravussin E (2006). Estimating the effects of energy imbalance on changes in body weight in children. Am J Clin Nutr 83, 859–863.

    Article  CAS  Google Scholar 

  • Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, Rosenbaum M et al. (2009). Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr 89, 1723–1728.

    Article  CAS  Google Scholar 

  • Swinburn BA, Sacks G, Ravussin E (2010). Reply to KD Hall and CC Chow. Am J Clin Nutr 91, 817.

    Article  CAS  Google Scholar 

  • Temple JL (2009). Caffeine use in children: what we know, what we have left to learn, and why we should worry. Neurosci Biobehav Rev 33, 793–806.

    Article  CAS  Google Scholar 

  • Tijms H (2004). Understanding Probability: Chance Rules in Everyday life. Cambridge University Press: Cambridge.

    Google Scholar 

  • Troiano RP, Briefel RR, Carroll MD, Bialostosky K (2000). Energy and fat intakes of children and adolescents in the United States: data from the national health and nutrition examination surveys. Am J Clin Nutr 72, 1343S–1353S.

    Article  CAS  Google Scholar 

  • US Census Bureau (2008). Age groups and sex: 2000 (online). Available at: http://factfinder.census.gov/servlet/QTTable?_bm=y&-geo_id=01000US&-qr_name=DEC_2000_SF1_U_QTP1&-ds_name=DEC_2000_SF1_U. (Accessed November 2008).

  • US Census Bureau (2009). Census of population and housing (online). Available at: http://www.census.gov/prod/www/abs/decennial/ (accessed March 2009).

  • USDA (2008). Nutrient intakes from food: mean amounts consumed per individual, one day, 2005–2006 (online). Available: http://www.ars.usda.gov/SP2UserFiles/Place/12355000/pdf/0506/Table_1_NIF_05.pdf (accessed February 2009).

  • Wang YC, Bleich SN, Gortmaker SL (2008). Increasing caloric contribution from sugar-sweetened beverages and 100% fruit juices among US children and adolescents, 1988–2004. Pediatrics 121, e1604–e1614.

    Article  Google Scholar 

  • Wang YC, Ludwig DS, Sonneville K, Gortmaker SL (2009). Impact of change in sweetened caloric beverage consumption on energy intake among children and adolescents. Arch Pediatr Adolesc Med 163, 336–343.

    Article  Google Scholar 

  • Yeomans MR, Jackson A, Lee MD, Steer B, Tinley E, Durlach P et al. (2000). Acquisition and extinction of flavour preferences conditioned by caffeine in humans. Appetite 35, 131–141.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank Professor Roland Griffiths for kindly providing a copy of PepsiCo (1981) reference. This research was funded by Diabetes Australia Research Trust and funding from the Faculty of Health, Medicine, Nursing and Behavioural Sciences, Deakin University, Australia.

Author contributions

Our responsibilities were as follows: RK, LR and BS conceived the study and helped conceptualize ideas, interpret findings and reviewed drafts of the manuscripts. DS was involved in data collection, interpretation of findings and reviewed drafts of manuscripts. GS and BS were involved with population modelling and reviewed drafts of the manuscripts. RK led the writing.

Trial registration: Australia and New Zealand Clinical Trial Registry 2608000151336.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R S J Keast.

Ethics declarations

Competing interests

The authors declare no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Keast, R., Sayompark, D., Sacks, G. et al. The influence of caffeine on energy content of sugar-sweetened beverages: ‘the caffeine–calorie effect’. Eur J Clin Nutr 65, 1338–1344 (2011). https://doi.org/10.1038/ejcn.2011.123

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ejcn.2011.123

Keywords

This article is cited by

Search

Quick links