Short Communication

European Journal of Clinical Nutrition (2010) 64, 765–767; doi:10.1038/ejcn.2010.81; published online 2 June 2010

α-Lactalbumin-enriched and probiotic-supplemented infant formula in infants with colic: growth and gastrointestinal tolerance

C Dupont1, M Rivero2, C Grillon3, N Belaroussi4, A Kalindjian5 and V Marin6

  1. 1Service de Néonatologie et Nutrition, Hôpital St Vincent de Paul, Université Paris Descartes, Paris, France
  2. 2Research and Development Department, Ordesa Group, Barcelona, Spain
  3. 318 rue de l'Abreuvoir, 77100 Meaux, France
  4. 4108 rue Point du Jour, 92100 Boulogne Billancourt, France
  5. 572 avenue Victor Cresson, 92130 Issy les Moulineaux, France
  6. 6Department of Development Sodilac, Levallois Perret cedex, France

Correspondence: Professeur C Dupont, Service de néonatologie et nutrition, Hôpital Saint Vincent de Paul, 82, avenue Denfert-Rochereau, 75674 Paris cedex 14, France. E-mail:

Received 24 October 2009; Revised 16 April 2010; Accepted 19 April 2010; Published online 2 June 2010.



Studies undertaken with α-lactalbumin-enriched formulae never addressed infants with colic. This study evaluated the nutritional adequacy, the gastrointestinal tolerance and the effect on colic of an α-lactalbumin-enriched and probiotic-supplemented formula. A double-blind, placebo-controlled study enrolled 66 healthy infants with colic, aged 3 weeks to 3 months, fed during 1 month with the either experimental formula (EF, Modilac Digest 1) or control formula (CF) and evaluated for efficacy and safety parameters at days 15 and 30. Weight and height gains were identical in the two groups and complied with standards (1023.4±360.4g (EF) and 1047.4±372.1g (CF), NS; 4.2±1.4cm (EF) and 4.3±1.9cm (CF), NS). No differences were found between groups for crying duration. ‘Feeding-related’ gastrointestinal side effects were significantly lower with EF than with CF (P=0.011). An α-lactalbumin-enriched and probiotic-supplemented formula guaranteed good weight and length gains to infants with colic and seemed to provide good gastrointestinal tolerance.


colic; infant formula; α-lactalbumin; protein composition; probiotics



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