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Lutein absorption in premature infants

Abstract

The objective of this study was to measure lutein and zeaxanthin plasma levels after oral lutein administration in preterm infants. Lutein was given orally in a single dose of 0.5 mg/kg to 10 preterm infants at a mean age of 52 h of life. Plasma lutein and zeaxanthin were measured before and 6, 24, 48, and 120 h after lutein administration. All infants had detectable plasma levels of lutein and zeaxanthin before treatment. Lutein concentration increased by 13.5% at 6 h and by 16.7% at 24 h, and returned to the basal level at 120 h after treatment. Zeaxanthin remained unchanged during the study period. Lutein is well absorbed in preterm infants when given orally. The clinical impact of increasing plasma lutein concentrations on macular development and visual function needs further investigation.

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References

  • Jewell VC, Northrop-Clewes CA, Tubman R, Thurnham DI (2001). Nutritional factors and visual function in prelature infants. Proc Nutr Soc 60, 171–178.

    Article  CAS  Google Scholar 

  • Khachik F, Beecher GR, Smith Jr JC (1995). Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. J Cell Biochem Suppl 22, 236–246.

    Article  CAS  Google Scholar 

  • Landrum J, Bone R (2001). Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys 385, 28–40.

    Article  CAS  Google Scholar 

  • Leung AKC, Siu TO, Chiu ASK, Robson WLM, Larsen TE (1990). Serum carotene concentrations in normal infants and children. Clin Pediatr 29, 575–578.

    Article  CAS  Google Scholar 

  • O’Brien D, Hammond KB (1987). Normal and therapeutic biochemical and hematologic values. In: Kempe CH (ed). Current Pediatric Diagnosis and Treatment. Appleton-Century-Crofts and Fleschner: Norwalk, CT. p 1129.

    Google Scholar 

  • Sommerburg O, Meissner K, Nelle M, Lenhartz H, Leichsenring M (2000). Carotenoid supply in breast-fed and formula-fed Neonates. Eur J Pediatr 159, 86–90.

    Article  CAS  Google Scholar 

  • Yeum K-J, Ferland G, Patry J, Russell RM (1998). Relationship of plasma carotenoids, retinol and tocopherols in mothers and newborn infants. J Am Coll Nutr 17, 442–447.

    Article  CAS  Google Scholar 

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Acknowledgements

We gratefully acknowledge Miss Marta Romagnoli for correcting the English manuscript.

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Correspondence to C Romagnoli.

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Romagnoli, C., Tirone, C., Persichilli, S. et al. Lutein absorption in premature infants. Eur J Clin Nutr 64, 760–761 (2010). https://doi.org/10.1038/ejcn.2010.62

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  • DOI: https://doi.org/10.1038/ejcn.2010.62

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