Short Communication

European Journal of Clinical Nutrition (2010) 64, 436–438; doi:10.1038/ejcn.2009.159; published online 20 January 2010

Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.)

V Vuksan1,2,3,4,5, A L Jenkins1, A G Dias1,3, A S Lee1,3, E Jovanovski1, A L Rogovik1 and A Hanna4,5

  1. 1Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, Ontario, Canada
  2. 2Keenan Research Center of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada
  3. 3Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
  4. 4Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
  5. 5Division of Endocrinology and Metabolism, St Michael's Hospital, Toronto, Ontario, Canada

Correspondence: Dr V Vuksan, Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, 70 Richmond Street East, Suite 100, Toronto, Ontario, M5C 1N8, Canada. E-mail: v.vuksan@utoronto.ca

Received 28 July 2009; Revised 24 October 2009; Accepted 6 November 2009; Published online 20 January 2010.

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Abstract

Despite strong correlations linking whole-grain consumption to reductions in heart disease, the physiological mechanisms involved remain ambiguous. We assessed whether Salba (Salvia Hispanica L.) whole grain reduces postprandial glycemia in healthy subjects, as a possible explanation for its cardioprotective effects observed in individuals with diabetes. The study used acute, randomized, double-blind, controlled design in which 11 healthy individuals (6 males and 5 females; body mass index 22.3±2.8kg/m2) received 0, 7, 15 or 24g of Salba baked into white bread. Capillary samples and appetite ratings were collected over 2h after consumption. A dose-response reduction in postprandial glycemia (P=0.002, r2=0.203) was observed with all three doses of Salba, significantly decreasing incremental areas under the curve (iAUCs) and time point-specific blood glucose (P<0.05). Appetite ratings were decreased at 60min after high, 90min after high and intermediate and at 120min after all treatments (P<0.05). Decrease in postprandial glycemia provides a potential explanation for improvements in blood pressure, coagulation and inflammatory markers previously observed after 12-week Salba supplementation in type II diabetes.

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