Original Article

European Journal of Clinical Nutrition (2009) 63, 121–126; doi:10.1038/sj.ejcn.1602891; published online 22 August 2007

Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients

Contributors: RJFM, SFEP, WHMS and LJCvL designed the study. RJFM and MHV organized and carried out the clinical trials. RJFM performed all calculations and the statistical analyses. All authors contributed to the final version of the manuscript.

R J F Manders1, S F E Praet2, M H Vikström1, W H M Saris1 and L J C van Loon1,2

  1. 1Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands
  2. 2Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands

Correspondence: RJF Manders, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands. E-mail: R.Manders@HB.unimaas.nl

Received 10 April 2007; Revised 13 June 2007; Accepted 20 July 2007; Published online 22 August 2007.

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Abstract

Objective:

 

Evaluate the efficacy of protein hydrolysate co-ingestion as a dietary strategy to improve blood glucose homeostasis under free-living conditions in long-standing type 2 diabetes patients.

Methods:

 

A total of 13 type 2 diabetes patients were enrolled in a randomized, double-blind cross-over design and studied on two occasions for 40 h under strict dietary standardization but otherwise normal, free-living conditions. In one trial, subjects ingested a protein hydrolysate (0.4 g kg-1 bw casein hydrolysate, PRO) with every main meal. In the other trial, a placebo was ingested (PLA). Blood glucose concentrations were assessed by continuous glucose monitoring.

Results:

 

Average 24 h glucose concentrations were similar between the PLA and the PRO trials (8.9plusminus0.8 vs 9.2plusminus0.7 mmol l-1, respectively). Hyperglycemia (glucose concentrations >10 mmol l-1) was experienced 34plusminus9% of the time (8plusminus2 h per 24 h) in the PLA trial. Protein hydrolysate co-ingestion with each main meal (PRO) did not reduce the prevalence of hyperglycemia (39plusminus10%, 9plusminus2 h per 24 h; P=0.2).

Conclusion:

 

Co-ingestion of a protein hydrolysate with each main meal does not improve glucose homeostasis over a 24 h period in long-standing type 2 diabetes patients.

Keywords:

postprandial glycemia, protein, continuous glucose monitoring

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