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Effect of intradialytic parenteral nutrition in patients with malnutrition–inflammation complex syndrome on body weight, inflammation, serum lipids and adipocytokines: results from a pilot study

European Journal of Clinical Nutrition volume 62, pages 789–795 (2008)Cite this article

Abstract

Objective:

Evaluation of the influence of intradialytic parenteral nutrition (IDPN) in patients suffering from Malnutrition–Inflammation Complex Syndrome (MICS) on nutritional status, inflammation, adipocytokines and serum lipids.

Subjects:

Six patients with MICS were assigned to IDPN, whereas six patients matched for age, sex, body mass index (BMI) and co-morbidity without malnutrition served as controls. Patients were recruited from Outpatient Dialysis Unit, Medical University Innsbruck and from Dialysis Unit, Hospital Feldkirch.

Results:

In all patients with IDPN, dry body weight increased during the interventional period whereas body weight remained stable in patients without IDPN. Tumor necrosis factor (TNF)-α levels were higher in patients with MICS compared with controls at all time points. Total cholesterol, LDL- and HDL-levels significantly increased during dialysis at all time points in controls but not in patients with MICS. Albumin, C-reactive protein, interleukin-6 (IL-6), soluble interleukin-2 receptor (sIL-2R) and adipocytokines did not differ between patients and controls during the study period.

Conclusions:

IDPN in patients with MICS increases body weight despite not influencing inflammatory status. Furthermore, IDPN does not induce a pro-atherogenic lipid composition enhancing the risk for atherosclerosis. Thus, IDPN is a safe and effective treatment of malnutrition in patients with MICS.

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Author notes

  1. M Joannidis and M Rauchenzauner: The first two authors contributed equally to this paper.

Authors and Affiliations

  1. Division of General Internal Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria

    M Joannidis, M Rauchenzauner, B Leiner, C F Ebenbichler, M Laimer & T Tatarczyk

  2. Division of Nephrology, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria

    A Rosenkranz & G Mayer

  3. Department of Nephrology and Dialysis, Hospital Feldkirch, Feldkirch, Austria

    E Meusburger

  4. Department of Paediatrics, Division of Neuropaediatrics, Medical University Innsbruck, Innsbruck, Austria

    M Rauchenzauner

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  1. M Joannidis
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  2. M Rauchenzauner
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  3. B Leiner
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Correspondence to M Joannidis.

Additional information

Guarantors: M Joannidis and G Mayer.

Contributors: MJ designed the study. MR, MJ and EM carried out this study and were responsible for recruitment of patients and for laboratory assays. BL carried out this study as part of his MD project. The work was supervised by GM, CE and AR who also analyzed data together with TT. The paper was drafted by MR, MJ and ML. All authors reviewed and approved the final version.

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Joannidis, M., Rauchenzauner, M., Leiner, B. et al. Effect of intradialytic parenteral nutrition in patients with malnutrition–inflammation complex syndrome on body weight, inflammation, serum lipids and adipocytokines: results from a pilot study. Eur J Clin Nutr 62, 789–795 (2008). https://doi.org/10.1038/sj.ejcn.1602777

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602777

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