Short Communication
European Journal of Clinical Nutrition (2008) 62, 570–574; doi:10.1038/sj.ejcn.1602724; published online 21 March 2007
Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial
Guarantor: M Fitó.
SOLOS (Spanish Olive Oil Study) Study Investigators: Alcántara M, Covas MI, Fitó M, Marrugat J, Schröder H, Weinbrenner T, Alcántara M, Muñoz D, Guxens M (Unitat de Lipids i Epidemiologia Cardiovascular, Institut Muncipal d'Investigació Mèdica), de la Torre R, Farré M, Menoyo E, Pujadas-Bastardes M, Closas N, Khymenets O (Unitat de Farmacologia, Institut Muncipal d'Investigació Mèdica), and de la Torre-Boronat C, Gimeno E, Lamuela R and López MC (Departament de Bromatologia i Nutricio, Facultat de Farmacia, Universitat de Barcelona).
Contributors: Drs MF, MC, and MIC had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of analyses; Study concept and design: MF, MC, MIC, RT, JM; Acquisition of the data: MA, DM, MF, MC, MP-B, JM, HS; Analysis and interpretation of data: MF, MC, MIC, RT, MCL-S, JM; Drafting of the manuscript: MF, MC, MIC; Critical revision of the manuscript for important intellectual content: MA, MC, MIC, MF, RT, HS, JM, JM, MCL-S, JB, DM, MP-B; Statistical analyses: MF, MC; Obtained funding: MC, MIC, JB; Administrative, technical and material support: MF, JM, DM, MP-B, HS, MA.
M Fitó1, M Cladellas2,3, R de la Torre4,5, J Martí2,3, D Muñoz1, H Schröder1, M Alcántara1, M Pujadas-Bastardes4, J Marrugat1,3, M C López-Sabater6, J Bruguera2, M I Covas1 and the members of the SOLOS Investigators
- 1Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain
- 2Servei de Cardiologia, Hospital del Mar, Barcelona, Spain
- 3Universitat Autònoma de Barcelona, Barcelona, Spain
- 4Unitat de Recerca de Farmacologia, Institut Municipal d'Investigació Médica (IMIM), Barcelona, Spain
- 5Universitat Pompeu Fabra, Barcelona, Spain
- 6Unitat de Nutrició i Bromatologia, Facultat de Farmàcia de Barcelona, Barcelona, Spain
Correspondence: Dr M Fitó, Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica (IMIM-Hospital del Mar), Parc de Recerca Biomèdica de Barcelona (PRBB), Carrer Doctor Aiguader, 88, 08003 Barcelona, Spain. E-mail: mfito@imim.es
Received 23 October 2006; Revised 12 January 2007; Accepted 5 February 2007; Published online 21 March 2007.
Abstract
Objectives:
To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients.
Design:
Placebo-controlled, crossover, randomized trial.
Setting:
Cardiology Department of Hospital del Mar and Institut Municipal d'Investigació Mèdica (Barcelona).
Subjects:
Twenty-eight stable coronary heart disease patients.
Interventions:
A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used.
Results:
Interleukin-6 (P<0.002) and C-reactive protein (P=0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile.
Conclusions:
Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.
Keywords:
olive oil, phenolic compounds, inflammation, interleukins, coronary heart disease