Original Article

European Journal of Clinical Nutrition (2008) 62, 232–237; doi:10.1038/sj.ejcn.1602719; published online 14 March 2007

Probiotic capsules do not lower plasma lipids in young women and men

Guarantor: MS Kurzer.

Contributors: KAG was the primary author, assisted with subject recruiting and study coordination, and performed the lipid analysis; MJLB, JMH-R and MHM assisted with subject recruiting and study coordination, KEW assisted with study design; WRP assisted with study design and provided medical consulting; JF assisted with study design and provided microbiological consulting; WT assisted with study design and statistical analysis; MSK was the principal investigator and supervised all aspects of the study. All authors contributed to the data interpretation and manuscript preparation.

K A Greany1, M J L Bonorden1, J M Hamilton-Reeves1, M H McMullen1, K E Wangen1, W R Phipps2, J Feirtag1, W Thomas3 and M S Kurzer1

  1. 1Department of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA
  2. 2Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA
  3. 3Department of Biostatistics, University of Minnesota, Minneapolis, MN, USA

Correspondence: Professor MS Kurzer, Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave., St Paul, MN, 55108, USA. E-mail: mkurzer@umn.edu

Received 16 October 2006; Revised 17 January 2007; Accepted 5 February 2007; Published online 14 March 2007.

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Abstract

Objective:

 

To investigate the effect of probiotic capsules on plasma lipids.

Design:

 

A randomized, single-blinded, placebo-controlled, parallel-arm trial.

Subjects:

 

Fifty-five normocholesterolemic subjects ages 18–36 (33 premenopausal women and 22 men).

Intervention:

 

Each subject consumed either three probiotic capsules each containing a total of 109 colony-forming units Lactobacillus acidophilus and Bifidobacterium longum and 10–15 mg fructo-oligosaccharide or three placebo capsules daily for 2 months (men) or two menstrual cycles (women). Plasma lipids were measured before and following the intervention (during the early follicular phase for women).

Results:

 

Plasma concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride were not altered by consumption of probiotic or placebo capsules and were not different between treatment groups following the intervention.

Conclusions:

 

These results do not support a beneficial effect of Lactobacillus acidophilus strain DDS-1 and Bifidobacterium longum strain UABL-14 on plasma lipids in normocholesterolemic young women and men.

Sponsorship:

 

Supported by the Minnesota Agricultural Experiment Station and UAS Laboratories.

Keywords:

probiotic, cholesterol

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