Original Article

European Journal of Clinical Nutrition (2008) 62, 178–185; doi:10.1038/sj.ejcn.1602712; published online 7 March 2007

Coffee consumption, serum bold italic gamma-glutamyltransferase and risk of type II diabetes

Guarantor: S Bidel.

Contributors: All contributors have made substantial contributions to the intellectual content of the paper. SB was primarily responsible for the conception and design analysis and interpretation of data and drafting of the manuscript. KS contributed in statistical analysis. KS, GH, DHL, JK and JT contributed in analysis and interpretation of data, and critical revision of the manuscript for important intellectual content.

S Bidel1,2, K Silventoinen2, G Hu1,2, D-H Lee3, J Kaprio2,4 and J Tuomilehto1,2,5

  1. 1Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
  2. 2Department of Public Health, University of Helsinki, Helsinki, Finland
  3. 3Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea
  4. 4Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
  5. 5South Ostrobothnia Central Hospital, Seinäjoki, Finland

Correspondence: Dr S Bidel, Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. E-mail: siamak.bidel@ktl.fi

Received 6 October 2006; Revised 9 January 2007; Accepted 24 January 2007; Published online 7 March 2007.

Top

Abstract

Objectives:

 

To study the joint association of coffee consumption and serum gamma-glutamyltransferase (GGT) levels on the risk of developing type II diabetes.

Design, setting and subjects:

 

A total of 21 826 Finnish men and women who were 35–74 years of age and without any history of diabetes at baseline (years 1982, 1987, 1992 and 1997) were included in the present analyses. They were prospectively followed up for onset of type II diabetes (n=862 cases), death or until the end of the year 2002. Coffee consumption, serum GGT and other study parameters were determined at baseline using standardized measurements. Analyses were stratified by the serum GGT level classified into two classes using the 75th sex-specific percentiles as the cut point.

Results:

 

Coffee consumption was significantly and inversely associated with incident diabetes among both men and women. Serum GGT modified the association between coffee consumption and incident diabetes. Subjects in the high category of coffee consumption with the GGT level greater than or equal to75th percentile showed a significant inverse association for women, and for both sexes combined. The association was not significant in subjects with the GGT level less than or equal to75th percentile. There was a significant interaction effect of GGT and coffee consumption on risk of type II diabetes in data of women (P=0.05) and in both sexes combined (P=0.02).

Conclusions:

 

Habitual coffee consumption is associated with lower incidence of type II diabetes particularly in those with higher baseline serum GGT levels.

Keywords:

type II diabetes, coffee, italic gamma-glutamyltransferase, oxidative stress, glutathione

Extra navigation

.

naturejobs

More science jobs
Post a job for free

natureproducts


ADVERTISEMENT