Original Article
European Journal of Clinical Nutrition (2008) 62, 1426–1431; doi:10.1038/sj.ejcn.1602886; published online 5 September 2007
Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients
Contributors: SW contributed to the study design, completing trial, determining arterial elasticity and writing paper. A-QM contributed to the quality control and paper modifications. S-WS and Q-HQ contributed in subjects' selection. X-FZ contributed in determining serum free fatty acid composition. X-ZH contributed to quality control.
S Wang1, A-Q Ma1, S-W Song2, Q-H Quan2, X-F Zhao3 and X-H Zheng3
- 1Department of Cardiology, Ion Channel Disease Laboratory, Environment and Disease Associated Gene Ministry of Education Intensive Laboratory, First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China
- 2Department of Internal Medicine, Employee General Hospital of JDC Molybdenum Mining Corporation, Huaxian, Shaanxi, China
- 3School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China
Correspondence: Professor A-Q Ma, 74 on Xiaozhaixi Road, Xi'an, Shaanxi 710061, China. E-mail: maaiqun@medmail.com.cn
Received 27 April 2006; Revised 13 March 2007; Accepted 18 July 2007; Published online 5 September 2007.
Abstract
Objectives:
To observe the effect of fish oil supplementation on arterial elasticity and blood pressure (BP) in overweight hypertensive patients.
Subjects and methods:
This was a double-blind, randomized and placebo-controlled clinical study, in which 52 overweight hypertensive patients from a community were selected and randomly allocated to two groups (26 in the fish oil group (3 g day-1, fish oil capsules) and 26 in the placebo group (only capsules). All the subjects were follow-up for 8 weeks. The arterial elasticity was determined by CVProfilor DO-2020 and expressed as elasticity indexes (C1-large artery and C2-small artery). During the follow-up, totally nine cases were dropped out (three cases from the fish oil group and six cases from the placebo group).
Results:
After 8 weeks follow-up, the large artery elasticity in the fish oil group, compared with its baseline, was significantly improved (C1: 15.5
1.5 vs 12.83.7 ml mm Hg-1 
10), whereas no effects were found in the placebo group (C1: 13.03.4 vs 13.43.8 ml mm Hg-1 10), P=0.027, RM-ANOVA across the two groups. The small artery elasticity (C2), BP and pulse pressure were not found any changes, either in the fish oil group or in the placebo group. At same time, the serum soluble vascular cell adhesion molecule-1(sVCAM-1) and leptin levels, the lipid profile and insulin sensitivity index (ISI) as well, did not show significant differences between two groups.
Conclusions:
Fish oil supplementation certainly would improve large arterial elasticity but no effect on BP in overweight hypertensive patients. Further study is needed to confirm the benefits of fish oil supplementation on age-related increases in arterial stiffness.
Keywords:
large arterial elasticity, hypertension, fish oil, overweight
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