Original Article
European Journal of Clinical Nutrition (2007) 61, 1121–1127; doi:10.1038/sj.ejcn.1602626; published online 31 January 2007
Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial
Guarantor: HE Bartlett.
Contributors: HEB and FE contributed to the design of the trial, statistical analyses, and preparation of the manuscript. HEB collected the data. HEB and FE read and approved the final manuscript.
1Opthalmic Research Group, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
Correspondence: Dr HE Bartlett, Opthalmic Research Group, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK. E-mail: H.E.Bartlett@aston.ac.uk
Received 30 March 2006; Revised 23 November 2006; Accepted 23 November 2006; Published online 31 January 2007.
Abstract
Objective:
The aim of the study is to determine the effect of lutein combined with vitamin and mineral supplementation on contrast sensitivity in people with age-related macular disease (ARMD).
Design:
A prospective, 9-month, double-masked randomized controlled trial.
Setting:
Aston University, Birmingham, UK and a UK optometric clinical practice.
Subjects:
Age-related maculopathy (ARM) and atrophic age-related macular degeneration (AMD) participants were randomized (using a random number generator) to either placebo (n=10) or active (n=15) groups. Three of the placebo group and two of the active group dropped out.
Interventions:
The active group supplemented daily with 6 mg lutein combined with vitamins and minerals. The outcome measure was contrast sensitivity (CS) measured using the Pelli–Robson chart, for which the study had 80% power at the 5% significance level to detect a change of 0.3 log units.
Results:
The CS score increased by 0.07
0.07 and decreased by 0.020.18 log units for the placebo and active groups, respectively. The difference between these values is not statistically significant (z=-0.903, P=0.376).
Conclusion:
The results suggest that 6 mg of lutein supplementation in combination with other antioxidants is not beneficial for this group. Further work is required to establish optimum dosage levels.
Keywords:
age-related macular disease, lutein, randomized controlled trial, nutrition, antioxidants
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