Original Article
European Journal of Clinical Nutrition (2007) 61, 221–225. doi:10.1038/sj.ejcn.1602519; published online 13 September 2006
Relationship between a wide range of alcohol consumptions, components of the insulin-like growth factor system and adiponectin
Guarantor: L Dal Maso.
Contributors: LDM drafted the manuscript with CLV and SF; LDM was responsible for statistical analyses; LSAA, CSM and CWCK were responsible for IGFs and adiponectin measurements. All authors conceived the study protocol and critically revised the manuscript.
L Dal Maso1, C La Vecchia2,3, L S A Augustin4, C S Mantzoros5, C W C Kendall4 and S Franceschi6
- 1Epidemiology and Biostatistics Unit, Aviano Cancer Center, IRCCS, Aviano, Italy
- 2Laboratory of General Epidemiology, Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy
- 3Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy
- 4Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and the Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, Ontario, Canada
- 5Human Nutrition Research Unit, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
- 6International Agency for Research on Cancer, Lyon, France
Correspondence: Dr L Dal Maso, Epidemiology and Biostatistics Unit, Aviano Cancer Center, Via Pedemontana Occ.le 12, Aviano PN 33081, Italy. E-mail: epidemiology@cro.it
Received 12 January 2006; Revised 3 July 2006; Accepted 4 July 2006; Published online 13 September 2006.
Abstract
Objective:
To explore the relation between a wide range of alcohol consumptions and levels of the components of insulin-like growth factor system (IGFs) and adiponectin in humans.
Design:
A cross-sectional study using controls from a case–control study on ovarian and endometrial cancer.
Settings:
The study included women hospitalized between 1999 and 2002 in Pordenone, Italy.
Subjects:
One hundred and eight cancer-free (controls) with a median age of 61 years (range 29–79 years), admitted for acute conditions unrelated to gynecologic, hormonal or metabolic disorders or diseases leading to dietary modifications.
Interventions:
Levels of IGF-I (total and free), total IGF-II, IGF-binding protein 1 (IGFBP-1), IGFBP-3 and adiponectin were individually measured, and their distributions across strata of alcohol consumption were tested by the Kruskal–Wallis statistic.
Results:
Median concentrations of total IGF-I were higher (P<0.01) in women reporting low (151 ng/ml) or no alcohol consumption (134 ng/ml) compared to drinkers of 12–23 g/day (103 ng/ml) or 
24 g/day (118 ng/ml). Median concentrations were higher (P=0.05) for IGFBP-3 in non-drinkers (2333 ng/ml) and in light drinkers (2647 ng/ml) compared to drinkers of 24 g/day (2090 ng/ml). No statistically significant difference emerged for other IGFs across levels of alcohol intakes. Adiponectin was slightly lower for non-drinkers, compared to all drinkers categories.
Conclusions:
Our study suggests that alcohol consumption is related to circulating levels of components of the IGF system and adiponectin. These results may have a potential impact on the prevention of several chronic diseases.
Sponsorship:
Italian Association for Research on Cancer, Milan, Italy, and Italian League against Tumours, Milan, Italy.
Keywords:
insulin-like growth factor system, adiponectin, alcohol consumption
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