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Resting energy expenditure in females with cystic fibrosis: Is it affected by puberty?

European Journal of Clinical Nutrition volume 61, pages 1207–1212 (2007)Cite this article

Abstract

Objective:

The aims of this study were to determine the effect of puberty and the menstrual cycle on resting energy expenditure (REE) in females with cystic fibrosis (CF).

Design:

Cross-sectional study. All participants had measurements of REE, anthropometry and pubertal staging. The measurements in the postmenarche group were carried out both in the follicular and luteal phases of their menstrual cycle.

Setting:

CF outpatient clinic at the Children's Hospital at Westmead.

Subjects:

Fifty-six females with CF and pancreatic insufficiency (13 postmenarche) were recruited from the hospital clinic and 63 controls (21 postmenarche) were recruited through families and friends of hospital staff.

Results:

Females with CF had a higher REE than controls (111.6±12.8% of predicted from controls P<0.001). There was a significant effect of menarche on REE with a decrease in the postmenarche −470 kJ/24 h compared with premenarche after adjustment for fat-free mass, fat mass and group (control or CF). There was no difference in REE between the follicular and luteal phases for either CF or controls.

Conclusions:

Females with CF had raised REE that appeared to be independent of menarche. This study implies all females with CF and pancreatic insufficiency may need more intensive dietary management, owing to raised REE, to maintain growth and nutritional status, and possibly improve survival.

Sponsorship:

None.

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Acknowledgements

We are grateful for the support of the James Fairfax Institute of Paediatric Nutrition in particular Cheryl Frazer and The Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney in particular Rebecca Prior and Dr Samir Samman and to the staff of Cystic Fibrosis Clinic, the families from the Cystic Fibrosis Clinic and the families and friends of hospital staff who participated in the study.

Author information

Authors and Affiliations

  1. Department of Gastroenterology, The Children's Hospital at Westmead, Sydney, Australia

    A Barclay, J Yap & K J Gaskin

  2. Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia

    P V Asperen & P Cooper

  3. James Fairfax Institute of Paediatric Nutrition, University of Sydney, Sydney, Australia

    J R Allen, E Blyler, M A Gruca & K J Gaskin

Authors
  1. A Barclay
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  2. J R Allen
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  3. E Blyler
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  4. J Yap
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  5. M A Gruca
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  6. P V Asperen
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  7. P Cooper
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  8. K J Gaskin
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Corresponding author

Correspondence to K J Gaskin.

Additional information

Guarantors: JR Allen and KJ Gaskin.

Contributors: AB, JY and EB all participated in recruitment, measurements, analysis and interpretation of the results. PVA and PC helped with the recruitment. MG was involved in collection and analysis of data. KJG and JRA conceived the study, contributed to the study design and were involved in the interpretation of the results. All contributors were involved in the writing of the paper.

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Barclay, A., Allen, J., Blyler, E. et al. Resting energy expenditure in females with cystic fibrosis: Is it affected by puberty?. Eur J Clin Nutr 61, 1207–1212 (2007). https://doi.org/10.1038/sj.ejcn.1602637

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602637

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